iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	7.30e-32	109.5	431	505

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 1    vqvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekksg 75
           +qv+vk++dg ++ + ++p d+V+ LK++ie+++g+++++q+L ++G++Led+ ++++yg++d  ti+l +k++g
   Q: 431  IQVFVKNPDGGSHAYAIHPLDFVLSLKQQIEDRQGLQSQEQQLEFQGRVLEDWFDFKSYGIQDSITIILSRKREG 505
           79*******************************************************************998875 PP

Organism

Rattus norvegicus

Functional Description
(View)

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L (By similarity).

Protein Sequence
(Fasta)

MAVAQELYSF PASKLDSFVA QWLQPTREWK EEVLETVQTV EQFLRQENFR GERGPAQDVR 60
VLKVLKVGCF GNGTVLRSTT DVELVVFLSC FHSFQEEAKH HQAVLRLIQK RMSYCRDLLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTAATATAA ATGAATATAA ATGTATAAAA CGGGGGTTGG GGATTTAGCT CAGTGGTAGA 60
GTGCTTGCCT AGCAAGCACA AGGCCCTGGG TTCGGTCCCC AGCTCCGAAA AAAAAAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0051--Antiviral defense
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding

Interpro

IPR006117--2-5-oligoadenylate_synth_CS
IPR006116--2-5-oligoadenylate_synth_N
IPR018952--2-5-oligoAdlate_synth_1_dom2/C
IPR026774--2-5A_synthase
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS00833--25A_SYNTH_2
PS50152--25A_SYNTH_3
PS50053--UBIQUITIN_2

Pfam

PF10421--OAS1_C
PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0003677--F:DNA binding
GO:0003725--F:double-stranded RNA binding
GO:0016740--F:transferase activity
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0045071--P:negative regulation of viral genome replication
GO:0009615--P:response to virus

KEGG

rno:304545

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002382	Ailuropoda melanoleuca	72.21	7.00e-152	531.00
IUUC-Bta-013441	Bos taurus	61.86	4.00e-120	424.00
IUUC-Cja-019721	Callithrix jacchus	69.22	0.00e+00	662.00
IUUC-Cfa-020283	Canis familiaris	70.43	0.00e+00	744.00
IUUC-Cpo-022264	Cavia porcellus	74.75	0.00e+00	786.00
IUUC-Csa-024258	Chlorocebus sabaeus	74.12	0.00e+00	751.00
IUUC-Cho-024633	Choloepus hoffmanni	71.98	0.00e+00	750.00
IUUC-Dno-029276	Dasypus novemcinctus	69.19	0.00e+00	730.00
IUUC-Dor-030563	Dipodomys ordii	61.67	9.00e-117	413.00
IUUC-Ete-032293	Echinops telfairi	68.35	0.00e+00	701.00
IUUC-Eca-033538	Equus caballus	72.82	0.00e+00	726.00
IUUC-Eeu-035066	Erinaceus europaeus	47.70	3.00e-85	308.00
IUUC-Fca-036598	Felis catus	71.71	7.00e-153	534.00
IUUC-Ggo-045019	Gorilla gorilla	73.91	0.00e+00	743.00
IUUC-Hsa-046427	Homo sapiens	73.72	0.00e+00	739.00
IUUC-Laf-054072	Loxodonta africana	72.80	0.00e+00	744.00
IUUC-Mcc-054678	Macaca mulatta	73.53	0.00e+00	744.00
IUUC-Meu-056079	Macropus eugenii	53.24	9.00e-103	366.00
IUUC-Mmr-061797	Microcebus murinus	67.98	0.00e+00	684.00
IUUC-Mdo-062316	Monodelphis domestica	47.17	4.00e-136	478.00
IUUC-Mmu-063442	Mus musculus	88.67	0.00e+00	927.00
IUUC-Mpu-066799	Mustela putorius furo	68.48	0.00e+00	691.00
IUUC-Mlu-067737	Myotis lucifugus	64.55	6.00e-165	573.00
IUUC-Nle-069345	Nomascus leucogenys	73.91	0.00e+00	740.00
IUUC-Opr-070745	Ochotona princeps	67.93	2.00e-176	611.00
IUUC-Ocu-073828	Oryctolagus cuniculus	69.32	0.00e+00	687.00
IUUC-Oga-089118	Otolemur garnettii	67.24	1.00e-131	462.00
IUUC-Oar-089587	Ovis aries	59.39	5.00e-163	567.00
IUUC-Ptr-091642	Pan troglodytes	72.96	0.00e+00	729.00
IUUC-Pan-091943	Papio anubis	73.92	0.00e+00	749.00
IUUC-Pab-097945	Pongo abelii	73.32	0.00e+00	738.00
IUUC-Pca-100234	Procavia capensis	71.29	0.00e+00	707.00
IUUC-Pva-102228	Pteropus vampyrus	67.38	0.00e+00	659.00
IUUC-Sha-106945	Sarcophilus harrisii	44.31	8.00e-121	427.00
IUUC-Sar-113443	Sorex araneus	60.88	3.00e-143	501.00
IUUC-Ssc-115350	Sus scrofa	59.82	3.00e-113	401.00
IUUC-Tgu-117171	Taeniopygia guttata	40.90	9.00e-98	350.00
IUUC-Tsy-119083	Tarsius syrichta	73.19	5.00e-133	468.00
IUUC-Tbe-127345	Tupaia belangeri	58.80	1.00e-147	516.00
IUUC-Ttr-128992	Tursiops truncatus	58.45	3.00e-108	384.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence