iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	21203937

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.00e-05	27.6	12	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++ +  ++ p++l+C+H+ +  Clq++    + s+k  rCP+Cr
   Q: 12   CQICFNYYspRRRPKLLDCKHTCCSVCLQQM----RTSQKDVRCPWCR 55
           9*****8888555***************999....99**********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).

Protein Sequence
(Fasta)

METLSQDSLL ECQICFNYYS PRRRPKLLDC KHTCCSVCLQ QMRTSQKDVR CPWCRGVTKL 60
PPGFSVSQLP DDPEVLAVIA IPHTSEHTPV FIKLPSNGCY MLPLPISKER ALLPGDMGCR 120

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Nucleotide Sequence
(Fasta)

GTCTGGCTGA AAGGAGCGGG CGCGCCGGGA CCACCCGGCG ATGCTGTCGC CGCCGCCGCC 60
GCCTCTGTAG CGAGCACCCG AGCCCGCCGC GGAGAAAGGT CAGTGAGTTT CGGTTTGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033609--RNF152
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF14634--zf-RING_5

SMART

SM00184--RING

Gene Ontology

GO:0031301--C:integral component of organelle membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0031267--F:small GTPase binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0034198--P:cellular response to amino acid starvation
GO:1904262--P:negative regulation of TORC1 signaling
GO:0010508--P:positive regulation of autophagy
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination

KEGG

hsa:220441

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001569	Ailuropoda melanoleuca	96.55	2.00e-114	404.00
IUUC-Aca-004700	Anolis carolinensis	94.09	5.00e-112	396.00
IUUC-Ame-011661	Astyanax mexicanus	55.88	5.00e-50	190.00
IUUC-Bdi-014339	Brachypodium distachyon	35.63	3.10e-02	33.10
IUUC-Cja-019799	Callithrix jacchus	99.01	2.00e-107	381.00
IUUC-Cfa-020144	Canis familiaris	94.58	4.00e-100	357.00
IUUC-Cpo-021632	Cavia porcellus	98.03	5.00e-115	406.00
IUUC-Csa-023858	Chlorocebus sabaeus	99.51	7.00e-108	382.00
IUUC-Cho-024669	Choloepus hoffmanni	95.20	2.00e-68	250.00
IUUC-Dre-027881	Danio rerio	58.82	6.00e-57	213.00
IUUC-Dno-029695	Dasypus novemcinctus	92.12	2.00e-98	351.00
IUUC-Dor-030795	Dipodomys ordii	97.04	9.00e-104	369.00
IUUC-Eca-033412	Equus caballus	98.52	3.00e-107	380.00
IUUC-Fca-036256	Felis catus	97.54	5.00e-107	379.00
IUUC-Fal-036943	Ficedula albicollis	92.61	3.00e-103	367.00
IUUC-Gga-040800	Gallus gallus	93.10	1.00e-110	392.00
IUUC-Ggo-045477	Gorilla gorilla	100.00	3.00e-117	413.00
IUUC-Itr-049081	Ictidomys tridecemlineatus	96.55	3.00e-113	400.00
IUUC-Lch-049770	Latimeria chalumnae	86.21	5.00e-97	346.00
IUUC-Loc-052353	Lepisosteus oculatus	87.83	3.00e-60	223.00
IUUC-Laf-054064	Loxodonta africana	97.04	2.00e-114	404.00
IUUC-Mcc-054875	Macaca mulatta	99.51	7.00e-108	382.00
IUUC-Meu-056370	Macropus eugenii	96.08	4.00e-113	400.00
IUUC-Mga-059847	Meleagris gallopavo	93.10	1.00e-110	391.00
IUUC-Mmr-061337	Microcebus murinus	98.52	3.00e-115	407.00
IUUC-Mdo-063047	Monodelphis domestica	95.10	2.00e-111	394.00
IUUC-Mmu-064228	Mus musculus	97.54	3.00e-109	387.00
IUUC-Mlu-067736	Myotis lucifugus	96.55	6.00e-101	359.00
IUUC-Nle-069697	Nomascus leucogenys	99.51	7.00e-108	382.00
IUUC-Ont-072208	Oreochromis niloticus	76.06	4.00e-87	313.00
IUUC-Oan-073566	Ornithorhynchus anatinus	84.80	3.00e-89	320.00
IUUC-Ocu-074089	Oryctolagus cuniculus	96.06	3.00e-102	363.00
IUUC-Obr-076611	Oryza brachyantha	40.82	2.30e-02	33.50
IUUC-Ola-087210	Oryzias latipes	71.36	7.00e-76	276.00
IUUC-Oga-088395	Otolemur garnettii	98.03	5.00e-105	373.00
IUUC-Oar-090382	Ovis aries	95.83	3.00e-21	92.80
IUUC-Ptr-091480	Pan troglodytes	100.00	3.00e-117	413.00
IUUC-Pan-091715	Papio anubis	99.51	7.00e-108	382.00
IUUC-Psi-093465	Pelodiscus sinensis	95.57	2.00e-112	397.00
IUUC-Pfo-097259	Poecilia formosa	76.89	7.00e-91	326.00
IUUC-Pab-097769	Pongo abelii	100.00	3.00e-117	413.00
IUUC-Pca-100657	Procavia capensis	97.54	3.00e-114	404.00
IUUC-Pva-102521	Pteropus vampyrus	98.03	5.00e-116	409.00
IUUC-Rno-105521	Rattus norvegicus	97.54	6.00e-115	406.00
IUUC-Sha-107197	Sarcophilus harrisii	96.57	2.00e-113	400.00
IUUC-Ssc-116239	Sus scrofa	97.04	9.00e-115	405.00
IUUC-Tru-118315	Takifugu rubripes	75.83	3.00e-83	300.00
IUUC-Tsy-119645	Tarsius syrichta	99.51	5.00e-117	413.00
IUUC-Tni-119835	Tetraodon nigroviridis	75.36	2.00e-87	315.00
IUUC-Tbe-127264	Tupaia belangeri	97.54	4.00e-110	390.00
IUUC-Ttr-128749	Tursiops truncatus	97.54	4.00e-109	387.00
IUUC-Vpa-130808	Vicugna pacos	97.54	4.00e-109	386.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence