iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-115252

UUCD1 version

UUC-SuS-00775

Ensembl Protein ID

ENSSSCP00000000973.2

UniProt Accession

Q7YRV6; SOCS2_PIG

Genbank Protein ID

AAP78900.1; ABL61533.1

Protein Name

Suppressor of cytokine signaling 2

Genbank Nucleotide ID

AY312266; EF121242

Gene Name

SOCS2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000000910.2	ENSSSCT00000000994.2	ENSSSCP00000000973.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	7.70e-16	58.0	153	197

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l ++ ++LqhLCRl+I++c+g+     i++LPLP +LkdYL+++++q
   Q: 153  TKPLYTSAPPLQHLCRLTINKCTGT-----IWGLPLPTRLKDYLEEYKFQ 197
           678999*******************.....8***************9886 PP

Organism

Sus scrofa

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Protein Sequence
(Fasta)

MTLRCLEPSG NGAEGTQSQW GTSGSAEEPS PEAARLAKAL RELSHTGWYW GSMTVNEAKE 60
KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGTCAGAG GAGGGCGGAT TCCCAGGCTT CTACCCTGCC CAGGTCCGCA CCCGAGCGCT 60
CCGAGCCCCG CTCCCATGAA GCCTGCGCAA TAGCGCCAGA GCCTCTTTAA AGCAGTAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0060396--P:growth hormone receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth
GO:0032355--P:response to estradiol

KEGG

ssc:100037966

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002075	Ailuropoda melanoleuca	97.98	3.00e-107	380.00
IUUC-Apl-003484	Anas platyrhynchos	79.74	2.00e-72	263.00
IUUC-Aca-004253	Anolis carolinensis	71.34	2.00e-71	260.00
IUUC-Ath-007106	Arabidopsis thaliana	35.59	1.90e-02	33.10
IUUC-Ame-011267	Astyanax mexicanus	62.28	5.00e-59	219.00
IUUC-Bta-013183	Bos taurus	97.47	4.00e-102	363.00
IUUC-Bra-017915	Brassica rapa	33.90	3.50e-02	32.30
IUUC-Cja-018862	Callithrix jacchus	95.96	2.00e-100	357.00
IUUC-Cfa-020226	Canis familiaris	96.95	1.00e-99	354.00
IUUC-Cpo-022414	Cavia porcellus	95.96	8.00e-105	372.00
IUUC-Csa-023758	Chlorocebus sabaeus	95.45	2.00e-104	370.00
IUUC-Cho-024471	Choloepus hoffmanni	86.84	4.00e-72	263.00
IUUC-Dre-028288	Danio rerio	56.48	1.00e-63	234.00
IUUC-Dno-029036	Dasypus novemcinctus	96.46	3.00e-106	376.00
IUUC-Dor-030447	Dipodomys ordii	98.68	2.00e-87	313.00
IUUC-Ete-033023	Echinops telfairi	93.43	2.00e-109	387.00
IUUC-Fca-036469	Felis catus	97.98	4.00e-102	362.00
IUUC-Fal-036642	Ficedula albicollis	73.46	3.00e-70	256.00
IUUC-Gmo-039331	Gadus morhua	66.30	3.00e-35	139.00
IUUC-Gga-040809	Gallus gallus	76.73	2.00e-72	264.00
IUUC-Gac-041398	Gasterosteus aculeatus	60.12	2.00e-59	221.00
IUUC-Ggo-045341	Gorilla gorilla	96.46	2.00e-100	357.00
IUUC-Hsa-046557	Homo sapiens	95.96	6.00e-113	399.00
IUUC-Itr-049013	Ictidomys tridecemlineatus	82.21	1.00e-92	331.00
IUUC-Lch-050160	Latimeria chalumnae	61.74	1.00e-49	188.00
IUUC-Loc-051825	Lepisosteus oculatus	56.25	5.00e-61	226.00
IUUC-Laf-053560	Loxodonta africana	94.95	3.00e-98	350.00
IUUC-Mcc-055890	Macaca mulatta	95.45	2.00e-99	353.00
IUUC-Meu-056218	Macropus eugenii	79.80	3.00e-95	340.00
IUUC-Mga-059755	Meleagris gallopavo	78.95	6.00e-71	259.00
IUUC-Mmr-061387	Microcebus murinus	96.97	2.00e-105	374.00
IUUC-Mdo-062383	Monodelphis domestica	81.82	5.00e-96	342.00
IUUC-Mmu-063443	Mus musculus	93.94	1.00e-101	361.00
IUUC-Mpu-066459	Mustela putorius furo	97.47	1.00e-101	361.00
IUUC-Mlu-068040	Myotis lucifugus	96.97	3.00e-107	380.00
IUUC-Nle-069016	Nomascus leucogenys	91.92	3.00e-98	350.00
IUUC-Opr-071087	Ochotona princeps	88.89	1.00e-103	368.00
IUUC-Ont-072340	Oreochromis niloticus	56.25	1.00e-59	222.00
IUUC-Oan-073443	Ornithorhynchus anatinus	79.29	4.00e-91	326.00
IUUC-Ocu-074539	Oryctolagus cuniculus	96.45	5.00e-101	359.00
IUUC-Ola-087004	Oryzias latipes	59.49	1.00e-54	204.00
IUUC-Oga-088438	Otolemur garnettii	95.45	3.00e-104	370.00
IUUC-Oar-089932	Ovis aries	97.47	6.00e-102	362.00
IUUC-Ptr-091037	Pan troglodytes	96.46	2.00e-100	357.00
IUUC-Pan-092767	Papio anubis	96.46	1.00e-100	357.00
IUUC-Psi-093099	Pelodiscus sinensis	76.73	2.00e-73	267.00
IUUC-Pma-094671	Petromyzon marinus	46.11	3.00e-36	144.00
IUUC-Pfo-097073	Poecilia formosa	50.00	2.00e-55	207.00
IUUC-Pab-098319	Pongo abelii	95.96	1.00e-105	375.00
IUUC-Pca-101117	Procavia capensis	94.44	4.00e-100	356.00
IUUC-Pva-102117	Pteropus vampyrus	96.46	4.00e-99	353.00
IUUC-Rno-105913	Rattus norvegicus	93.43	4.00e-101	360.00
IUUC-Sha-106500	Sarcophilus harrisii	81.73	1.00e-94	338.00
IUUC-Tgu-117524	Taeniopygia guttata	75.47	9.00e-70	254.00
IUUC-Tru-118511	Takifugu rubripes	39.16	2.00e-25	108.00
IUUC-Tsy-119335	Tarsius syrichta	94.04	2.00e-84	303.00
IUUC-Tni-120263	Tetraodon nigroviridis	54.79	9.00e-57	212.00
IUUC-Tbe-127915	Tupaia belangeri	96.46	4.00e-98	349.00
IUUC-Ttr-128372	Tursiops truncatus	99.49	1.00e-108	384.00
IUUC-Vpa-130422	Vicugna pacos	100.00	1.00e-88	317.00
IUUC-Xtr-132941	Xenopus tropicalis	70.12	2.00e-69	254.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence