iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-021231

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Suppressor of cytokine-signaling 3

Genbank Nucleotide ID

AAEX03006238

Gene Name

SOCS3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000005306.3	ENSCAFT00000008545.3	ENSCAFP00000007917.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	97.78	7.00e-108	387.00	IUUC-Hsa-046909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Protein Sequence
(Fasta)

MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL 60
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTCACCC ACAGCAAGTT TCCCGCCGCC GGGATGAGCC GCCCCCTGGA CACCAGCCTG 60
CGCCTCAAGA CCTTCAGCTC CAAGAGCGAG TACCAGCTGG TGGTGAACGC AGTGCGCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005622--C:intracellular
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0060674--P:placenta blood vessel development
GO:0045597--P:positive regulation of cell differentiation
GO:0016567--P:protein ubiquitination
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	96.89	1.00e-107	381.00
IUUC-Apl-003607	Anas platyrhynchos	82.22	1.00e-96	345.00
IUUC-Aca-005063	Anolis carolinensis	82.74	2.00e-103	367.00
IUUC-Ath-006990	Arabidopsis thaliana	32.94	8.00e-03	36.20
IUUC-Ame-010859	Astyanax mexicanus	56.96	1.00e-70	259.00
IUUC-Bta-012817	Bos taurus	91.70	4.00e-112	397.00
IUUC-Bra-017963	Brassica rapa	28.57	1.30e-01	31.20
IUUC-Cja-019605	Callithrix jacchus	96.89	1.00e-113	402.00
IUUC-Cpo-022003	Cavia porcellus	90.79	2.00e-107	381.00
IUUC-Csa-023511	Chlorocebus sabaeus	97.78	2.00e-112	398.00
IUUC-Dre-028536	Danio rerio	59.57	9.00e-74	269.00
IUUC-Dno-029003	Dasypus novemcinctus	92.00	1.00e-109	388.00
IUUC-Eca-034205	Equus caballus	84.36	5.00e-68	249.00
IUUC-Fca-036317	Felis catus	95.07	6.00e-108	383.00
IUUC-Gmo-038777	Gadus morhua	63.89	8.00e-36	142.00
IUUC-Gga-041258	Gallus gallus	82.67	9.00e-97	345.00
IUUC-Gac-041837	Gasterosteus aculeatus	56.33	1.00e-65	241.00
IUUC-Ggo-045620	Gorilla gorilla	97.78	2.00e-112	398.00
IUUC-Hsa-046909	Homo sapiens	97.78	2.00e-112	398.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	91.03	7.00e-112	396.00
IUUC-Lch-049510	Latimeria chalumnae	67.69	1.00e-84	305.00
IUUC-Loc-052863	Lepisosteus oculatus	63.91	5.00e-80	290.00
IUUC-Laf-054136	Loxodonta africana	91.67	5.00e-109	386.00
IUUC-Mcc-055383	Macaca mulatta	97.78	2.00e-112	398.00
IUUC-Meu-056153	Macropus eugenii	88.05	3.00e-110	390.00
IUUC-Mmr-061185	Microcebus murinus	94.25	3.00e-107	380.00
IUUC-Mdo-061819	Monodelphis domestica	88.89	2.00e-113	401.00
IUUC-Mmu-064231	Mus musculus	96.00	9.00e-119	419.00
IUUC-Mpu-066691	Mustela putorius furo	99.11	4.00e-109	386.00
IUUC-Mlu-067673	Myotis lucifugus	96.46	2.00e-116	411.00
IUUC-Ont-072406	Oreochromis niloticus	55.46	2.00e-68	251.00
IUUC-Oan-073249	Ornithorhynchus anatinus	74.67	8.00e-94	335.00
IUUC-Ocu-074935	Oryctolagus cuniculus	86.96	1.00e-31	127.00
IUUC-Ola-087373	Oryzias latipes	48.04	2.00e-48	184.00
IUUC-Oga-088041	Otolemur garnettii	92.44	2.00e-109	387.00
IUUC-Oar-089646	Ovis aries	89.52	2.00e-103	367.00
IUUC-Ptr-091502	Pan troglodytes	97.78	2.00e-112	398.00
IUUC-Pan-091934	Papio anubis	97.78	2.00e-112	398.00
IUUC-Pfo-096412	Poecilia formosa	42.79	3.00e-48	184.00
IUUC-Pab-098554	Pongo abelii	97.78	2.00e-112	398.00
IUUC-Rno-105874	Rattus norvegicus	96.44	7.00e-120	422.00
IUUC-Sha-107151	Sarcophilus harrisii	86.84	4.00e-110	390.00
IUUC-Ssc-115722	Sus scrofa	87.21	3.00e-65	240.00
IUUC-Tgu-117151	Taeniopygia guttata	83.11	4.00e-96	343.00
IUUC-Tru-118428	Takifugu rubripes	54.15	2.00e-68	251.00
IUUC-Tni-120590	Tetraodon nigroviridis	54.59	4.00e-67	247.00
IUUC-Ttr-129065	Tursiops truncatus	91.27	9.00e-111	392.00
IUUC-Xtr-132167	Xenopus tropicalis	65.33	2.00e-81	294.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence