iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013303

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 22; Deubiquitinating enzyme 22; Ubiquitin thioesterase 22; Ubiquitin-specific-processing protease 22

Genbank Nucleotide ID

EE333442

Gene Name

USP22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000008978.5	ENSBTAT00000011818.5	ENSBTAP00000011818.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.90e-93	311.1	166	509

Active Site

Position(s)	Description	Evidence
174	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
468	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++ +   +p+ +l++++ +lf+e+++++++   p +ll+ +++ a+++ gyeqq
   Q: 166  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHRCEMQ---SPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQ 250
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  ++ ++ +++++ +++i+++F g l+s+++c+ c+ vs++ +pf+d+sl++pg+
   Q: 251  DAHEFLIAALDVLHRHCKG----------------DDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGS 323
           *****************22................22335677899999**************************************** PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
           ++   +                    +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++kklP v ++hLkRf  +++ k r+k
   Q: 324  STPFWPlspgsessvvngeshvsgttTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRF--EHSAKLRRK 410
           *877779***********************************************************************..5666899** PP
   S: 249  inkkvefpleLdlspfcts............peekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevlee 325
           i+++v+fpleLd++pf++s            p+++ ++++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl  
   Q: 411  ITTYVSFPLELDMTPFMASskesrmngqyqqPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQWFKCDDAIITKASIADVLD- 498
           *******************5555555555554445555**************************************************. PP
   S: 326  tgstaYvlfYkrr 338
             s++Y+lfY+++
   Q: 499  --SEGYLLFYHKQ 509
           ..********985 PP

Organism

Bos taurus

Functional Description
(View)

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression (By similarity).

Protein Sequence
(Fasta)

MDAELVVTPP GCAHLGSFKV DNWKQNLRAI YQCFVWSGSA EARKRKAKSC VCHVCGLHLN 60
RLHSCLHCVF FGCFTKKHIH EHAKSKRHNL AIELMYGGIY CFLCQDYIYD KDIEIIAKEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCGATGAC GTAGCGCCGC CCCGGCCTCG GCGACCCGCA AACGCCTCGC GGGCGGTGCC 60
CGCCACTCAG TCGCTCTGCT CTGCTTTGTC CCGGGCCCGT CCGTCAGCCG GGCCGCCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0000124--C:SAGA complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0007049--P:cell cycle
GO:0016578--P:histone deubiquitination
GO:0016574--P:histone ubiquitination
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:509694

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	37.85	4.00e-65	242.00
IUUC-Aml-001343	Ailuropoda melanoleuca	97.08	0.00e+00	1049.00
IUUC-Atr-002653	Amborella trichopoda	37.43	1.00e-99	357.00
IUUC-Apl-003433	Anas platyrhynchos	92.36	0.00e+00	945.00
IUUC-Aca-005347	Anolis carolinensis	88.15	0.00e+00	999.00
IUUC-Aly-006565	Arabidopsis lyrata	34.22	1.00e-70	260.00
IUUC-Ath-007536	Arabidopsis thaliana	34.15	4.00e-71	262.00
IUUC-Ago-007811	Ashbya gossypii	30.46	2.00e-53	203.00
IUUC-Acl-008124	Aspergillus clavatus	31.21	9.00e-60	224.00
IUUC-Afl-008464	Aspergillus flavus	33.25	2.00e-55	209.00
IUUC-Afu-008912	Aspergillus fumigatus	31.63	1.00e-57	217.00
IUUC-Ani-009168	Aspergillus nidulans	33.02	8.00e-60	224.00
IUUC-Ang-009694	Aspergillus niger	32.11	2.00e-57	216.00
IUUC-Aor-010035	Aspergillus oryzae	35.58	4.00e-39	154.00
IUUC-Ate-010382	Aspergillus terreus	32.05	3.00e-53	202.00
IUUC-Ame-011253	Astyanax mexicanus	85.56	0.00e+00	835.00
IUUC-Bgr-012150	Blumeria graminis	31.20	2.00e-49	189.00
IUUC-Bci-013604	Botrytis cinerea	32.63	7.00e-58	218.00
IUUC-Bdi-014171	Brachypodium distachyon	35.15	3.00e-76	279.00
IUUC-Bol-016509	Brassica oleracea	37.61	1.00e-72	268.00
IUUC-Bra-016962	Brassica rapa	36.89	2.00e-71	263.00
IUUC-Cja-019283	Callithrix jacchus	98.11	0.00e+00	879.00
IUUC-Cfa-021239	Canis familiaris	98.94	0.00e+00	979.00
IUUC-Cpo-022354	Cavia porcellus	96.50	0.00e+00	1050.00
IUUC-Csa-023145	Chlorocebus sabaeus	97.47	0.00e+00	1061.00
IUUC-Cho-024938	Choloepus hoffmanni	95.69	2.00e-65	243.00
IUUC-Cin-025109	Ciona intestinalis	58.20	5.00e-122	430.00
IUUC-Csv-026214	Ciona savignyi	55.28	9.00e-173	600.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	32.10	7.00e-56	211.00
IUUC-Cne-027085	Cryptococcus neoformans	32.76	4.00e-63	235.00
IUUC-Dre-027433	Danio rerio	93.16	0.00e+00	924.00
IUUC-Dno-030095	Dasypus novemcinctus	96.80	0.00e+00	962.00
IUUC-Dor-030481	Dipodomys ordii	95.95	2.00e-99	355.00
IUUC-Dse-031415	Dothistroma septosporum	30.40	6.00e-62	231.00
IUUC-Dme-032074	Drosophila melanogaster	51.32	4.00e-139	488.00
IUUC-Ete-033175	Echinops telfairi	78.00	0.00e+00	714.00
IUUC-Eca-033736	Equus caballus	98.29	0.00e+00	969.00
IUUC-Eeu-034814	Erinaceus europaeus	96.80	4.00e-130	457.00
IUUC-Fca-035861	Felis catus	98.51	0.00e+00	972.00
IUUC-Fal-037645	Ficedula albicollis	92.65	0.00e+00	930.00
IUUC-Fox-038046	Fusarium oxysporum	31.40	5.00e-56	211.00
IUUC-Fso-038321	Fusarium solani	33.26	8.00e-56	211.00
IUUC-Gmo-038474	Gadus morhua	93.92	1.00e-170	592.00
IUUC-Ggr-040044	Gaeumannomyces graminis	32.10	3.00e-57	216.00
IUUC-Gga-040624	Gallus gallus	91.24	0.00e+00	1011.00
IUUC-Gac-042197	Gasterosteus aculeatus	85.71	0.00e+00	924.00
IUUC-Gma-042897	Glycine max	33.16	1.00e-84	307.00
IUUC-Ggo-044409	Gorilla gorilla	97.28	0.00e+00	1059.00
IUUC-Hsa-046521	Homo sapiens	97.47	0.00e+00	1062.00
IUUC-Hvu-047739	Hordeum vulgare	38.95	4.00e-70	258.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	96.89	0.00e+00	1053.00
IUUC-Kpa-049135	Komagataella pastoris	35.62	1.00e-68	253.00
IUUC-Lch-050537	Latimeria chalumnae	92.72	0.00e+00	1013.00
IUUC-Lpe-050969	Leersia perrieri	38.37	6.00e-73	268.00
IUUC-Loc-052765	Lepisosteus oculatus	82.52	0.00e+00	899.00
IUUC-Lma-053105	Leptosphaeria maculans	34.00	1.00e-68	254.00
IUUC-Laf-053571	Loxodonta africana	97.65	0.00e+00	964.00
IUUC-Mcc-055166	Macaca mulatta	97.47	0.00e+00	1061.00
IUUC-Mor-057103	Magnaporthe oryzae	32.29	3.00e-56	213.00
IUUC-Mpo-057621	Magnaporthe poae	32.31	1.00e-56	214.00
IUUC-Mtr-057894	Medicago truncatula	37.24	5.00e-85	308.00
IUUC-Mla-059185	Melampsora laricipopulina	29.95	2.00e-42	166.00
IUUC-Mga-059709	Meleagris gallopavo	92.36	0.00e+00	945.00
IUUC-Mvi-060530	Microbotryum violaceum	34.25	9.00e-59	221.00
IUUC-Mmr-060988	Microcebus murinus	97.47	0.00e+00	1059.00
IUUC-Mdo-063065	Monodelphis domestica	93.50	0.00e+00	1021.00
IUUC-Mmu-063829	Mus musculus	97.67	0.00e+00	1060.00
IUUC-Mac-065419	Musa acuminata	40.11	6.00e-72	265.00
IUUC-Mpu-066687	Mustela putorius furo	96.88	0.00e+00	1045.00
IUUC-Mlu-067330	Myotis lucifugus	81.73	0.00e+00	894.00
IUUC-Nfi-068423	Neosartorya fischeri	31.86	1.00e-57	217.00
IUUC-Ncr-068809	Neurospora crassa	29.52	1.00e-59	223.00
IUUC-Nle-069261	Nomascus leucogenys	93.58	0.00e+00	1007.00
IUUC-Opr-070469	Ochotona princeps	79.43	0.00e+00	685.00
IUUC-Ont-071961	Oreochromis niloticus	88.89	0.00e+00	967.00
IUUC-Oan-073565	Ornithorhynchus anatinus	85.96	0.00e+00	915.00
IUUC-Ocu-074435	Oryctolagus cuniculus	97.60	0.00e+00	1031.00
IUUC-Oba-075688	Oryza barthii	35.99	6.00e-76	278.00
IUUC-Obr-076652	Oryza brachyantha	41.69	1.00e-74	273.00
IUUC-Ogl-077910	Oryza glaberrima	35.89	2.00e-78	286.00
IUUC-Ogu-078479	Oryza glumaepatula	35.89	2.00e-78	286.00
IUUC-Oin-079697	Oryza indica	39.66	5.00e-76	278.00
IUUC-Olo-080811	Oryza longistaminata	41.38	5.00e-53	201.00
IUUC-Ome-081706	Oryza meridionalis	35.89	5.00e-78	285.00
IUUC-Oni-083070	Oryza nivara	35.48	2.00e-78	286.00
IUUC-Opu-083605	Oryza punctata	40.16	1.00e-67	249.00
IUUC-Oru-084522	Oryza rufipogon	35.89	2.00e-78	286.00
IUUC-Osa-085351	Oryza sativa	39.36	2.00e-76	280.00
IUUC-Ola-086743	Oryzias latipes	88.31	0.00e+00	755.00
IUUC-Olu-087695	Ostreococcus lucimarinus	32.08	1.00e-50	193.00
IUUC-Oga-089131	Otolemur garnettii	93.77	0.00e+00	1041.00
IUUC-Oar-089319	Ovis aries	100.00	0.00e+00	981.00
IUUC-Ptr-090783	Pan troglodytes	94.66	0.00e+00	971.00
IUUC-Pan-092927	Papio anubis	97.28	0.00e+00	1060.00
IUUC-Psi-093670	Pelodiscus sinensis	92.55	0.00e+00	944.00
IUUC-Pma-094323	Petromyzon marinus	70.33	0.00e+00	724.00
IUUC-Pno-095141	Phaeosphaeria nodorum	32.10	1.00e-57	217.00
IUUC-Pfo-096473	Poecilia formosa	90.55	0.00e+00	983.00
IUUC-Pab-097612	Pongo abelii	97.67	0.00e+00	1063.00
IUUC-Pop-099558	Populus trichocarpa	34.97	3.00e-88	319.00
IUUC-Pca-100329	Procavia capensis	81.73	0.00e+00	893.00
IUUC-Ppe-102020	Prunus persica	36.03	1.00e-93	337.00
IUUC-Pva-102721	Pteropus vampyrus	77.31	0.00e+00	832.00
IUUC-Pte-104340	Pyrenophora teres	32.80	2.00e-62	233.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	34.41	1.00e-68	253.00
IUUC-Rno-105247	Rattus norvegicus	97.67	0.00e+00	1061.00
IUUC-Sce-106247	Saccharomyces cerevisiae	31.39	3.00e-52	199.00
IUUC-Sha-107538	Sarcophilus harrisii	95.85	6.00e-124	436.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	34.69	3.00e-66	245.00
IUUC-Spo-108226	Schizosaccharomyces pombe	31.12	8.00e-61	227.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	32.11	5.00e-55	208.00
IUUC-Smo-109310	Selaginella moellendorffii	35.15	3.00e-86	312.00
IUUC-Sit-109716	Setaria italica	35.43	4.00e-79	288.00
IUUC-Sly-111077	Solanum lycopersicum	37.71	1.00e-82	300.00
IUUC-Stu-112203	Solanum tuberosum	40.55	4.00e-75	275.00
IUUC-Sar-113174	Sorex araneus	76.47	0.00e+00	790.00
IUUC-Sbi-114205	Sorghum bicolor	34.94	3.00e-80	292.00
IUUC-Ssc-115315	Sus scrofa	81.11	0.00e+00	892.00
IUUC-Tgu-116938	Taeniopygia guttata	95.31	0.00e+00	954.00
IUUC-Tru-117622	Takifugu rubripes	87.79	0.00e+00	981.00
IUUC-Tsy-119431	Tarsius syrichta	85.68	0.00e+00	813.00
IUUC-Tni-120661	Tetraodon nigroviridis	90.84	0.00e+00	999.00
IUUC-Tca-121154	Theobroma cacao	37.43	6.00e-91	328.00
IUUC-Tre-122139	Trichoderma reesei	31.66	8.00e-55	207.00
IUUC-Tvi-122599	Trichoderma virens	31.11	7.00e-56	211.00
IUUC-Tae-125608	Triticum aestivum	35.35	9.00e-86	310.00
IUUC-Tme-127115	Tuber melanosporum	38.27	1.00e-80	294.00
IUUC-Ttr-129006	Tursiops truncatus	81.57	0.00e+00	877.00
IUUC-Uma-129455	Ustilago maydis	31.63	1.00e-33	138.00
IUUC-Vda-129829	Verticillium dahliae	33.22	4.00e-36	144.00
IUUC-Vvi-131477	Vitis vinifera	35.70	9.00e-78	284.00
IUUC-Xtr-132444	Xenopus tropicalis	90.25	0.00e+00	1005.00
IUUC-Xma-133514	Xiphophorus maculatus	91.16	0.00e+00	997.00
IUUC-Yli-134357	Yarrowia lipolytica	30.81	7.00e-48	184.00
IUUC-Zma-134945	Zea mays	34.95	1.00e-76	280.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence