iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Dme-032074

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AE014296

Gene Name

not; anon-WO0257455.9; DmelCG4166; i155; l(3)02069; l(3)j9A6; Nonstop; nonstop; NOT; Not; Q9VVR1; UB

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0013717	FBtr0290259	FBpp0288698

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.60e-87	292.4	159	490

Active Site

Position(s)	Description	Evidence
167	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU01035}
450	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU01035}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflafl 99
           Gl Nlg+tC+mN+++Q+L+++p l +++ + +++++  +   +++++l++++ +lf+e+++++++  s ++ll+ +++ a+++ gyeqqDa+Ef+   
   Q: 159  GLLNLGATCFMNCIVQALVHTPLLSDYFMS-DRHDCGSK---SSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIAT 252
           9*****************************.99999875...78****************************************************** PP
   S: 100  ldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknk......slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeet...kkeslq 188
           ld l++++ k   k  +e+++++ s + +  ++++ ++++      ++i+++F g l+s+++c++c+ vs++++pf+d+sl++ + ++     +++l 
   Q: 253  LDVLHRHCVK--AKAEHESKSNS-SGSGSGTNSSNSSSSHcygqcnCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHggvTPKTLI 347
           ********44..22222222222.2222222222222222344455**************************************87754222466*** PP
   S: 189  dcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvH 286
           dcLe +t++e+l ++ k++c++ck++qe++k+++l++lP v ++hLkRf  +++   ++ki++ ++fp e+d++pf+++++++   + +++L+avv+H
   Q: 348  DCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRF--EHSALIDRKISSFIQFPVEFDMTPFMSEKKNAY-GDFRFSLYAVVNH 442
           *************************************************..66779***********************77665.6************ PP
   S: 287  sGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            G+++ GHY+ayv+++k+ W+++dD+ +t  + ++vl    s++Y+lfY++
   Q: 443  VGTIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLD---SEGYLLFYHK 490
           **************************************...********97 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MSETGCRHYQ SYVKEHSYDT FRVIDAYFAA CVNRDARERK AIHCNCFECG SYGIQLYACL 60
HCIYFGCRGA HITSHLRSKK HNVALELSHG TLYCYACRDF IYDARSREYA LINRKLEAKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCTTCTACC AACACATATG CGCGCGTGTG TATGTGTTTG CGTGCAGTGC GAAATAGAAA 60
CAAGAAAAGC AAGCGAAAAA TCACAGAAAT TCACAAAAAA AAAGCCCAAC TACTTCCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG4166

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	34.30	1.00e-52	200.00
IUUC-Aml-001343	Ailuropoda melanoleuca	50.94	1.00e-149	522.00
IUUC-Atr-002653	Amborella trichopoda	35.11	9.00e-83	300.00
IUUC-Apl-003433	Anas platyrhynchos	51.68	7.00e-144	503.00
IUUC-Aca-005347	Anolis carolinensis	49.73	3.00e-147	514.00
IUUC-Aly-006565	Arabidopsis lyrata	34.56	9.00e-66	243.00
IUUC-Ath-007536	Arabidopsis thaliana	31.29	3.00e-65	242.00
IUUC-Ago-007811	Ashbya gossypii	28.57	3.00e-52	198.00
IUUC-Acl-008124	Aspergillus clavatus	29.48	2.00e-57	216.00
IUUC-Afl-008464	Aspergillus flavus	31.93	5.00e-51	194.00
IUUC-Afu-008912	Aspergillus fumigatus	31.24	4.00e-57	214.00
IUUC-Ani-009168	Aspergillus nidulans	31.43	3.00e-55	208.00
IUUC-Ang-009694	Aspergillus niger	32.75	2.00e-57	215.00
IUUC-Aor-010035	Aspergillus oryzae	32.77	1.00e-34	139.00
IUUC-Ate-010382	Aspergillus terreus	32.00	2.00e-52	199.00
IUUC-Ame-011253	Astyanax mexicanus	50.41	7.00e-131	459.00
IUUC-Bgr-012150	Blumeria graminis	28.91	7.00e-43	167.00
IUUC-Bta-013303	Bos taurus	51.32	4.00e-150	523.00
IUUC-Bci-013604	Botrytis cinerea	30.43	4.00e-53	201.00
IUUC-Bdi-014171	Brachypodium distachyon	33.20	3.00e-69	255.00
IUUC-Bol-016509	Brassica oleracea	33.64	4.00e-70	258.00
IUUC-Bra-016962	Brassica rapa	35.11	5.00e-69	254.00
IUUC-Cja-019283	Callithrix jacchus	54.18	9.00e-134	469.00
IUUC-Cfa-021239	Canis familiaris	53.55	7.00e-147	512.00
IUUC-Cpo-022354	Cavia porcellus	51.42	3.00e-150	523.00
IUUC-Csa-023145	Chlorocebus sabaeus	51.23	9.00e-150	522.00
IUUC-Cin-025109	Ciona intestinalis	45.67	6.00e-90	323.00
IUUC-Csv-026214	Ciona savignyi	43.01	2.00e-126	444.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	31.20	3.00e-52	198.00
IUUC-Cne-027085	Cryptococcus neoformans	29.93	5.00e-61	228.00
IUUC-Dre-027433	Danio rerio	52.98	8.00e-145	506.00
IUUC-Dno-030095	Dasypus novemcinctus	52.75	1.00e-144	505.00
IUUC-Dor-030832	Dipodomys ordii	54.55	1.00e-56	212.00
IUUC-Dse-031415	Dothistroma septosporum	29.63	3.00e-55	208.00
IUUC-Ete-033175	Echinops telfairi	59.87	3.00e-48	185.00
IUUC-Eca-033736	Equus caballus	52.75	4.00e-144	503.00
IUUC-Eeu-034814	Erinaceus europaeus	54.76	5.00e-62	231.00
IUUC-Fca-035861	Felis catus	52.95	1.00e-144	505.00
IUUC-Fal-037645	Ficedula albicollis	52.01	7.00e-143	499.00
IUUC-Fox-038046	Fusarium oxysporum	30.02	4.00e-52	198.00
IUUC-Fso-038321	Fusarium solani	33.11	5.00e-51	194.00
IUUC-Gmo-038474	Gadus morhua	54.92	1.00e-93	335.00
IUUC-Ggr-040044	Gaeumannomyces graminis	30.61	2.00e-50	192.00
IUUC-Gga-040624	Gallus gallus	50.18	6.00e-148	516.00
IUUC-Gac-042197	Gasterosteus aculeatus	49.25	4.00e-143	500.00
IUUC-Gma-042897	Glycine max	33.05	5.00e-73	267.00
IUUC-Ggo-044409	Gorilla gorilla	50.94	1.00e-149	522.00
IUUC-Hsa-046521	Homo sapiens	50.94	2.00e-149	521.00
IUUC-Hvu-047739	Hordeum vulgare	36.24	3.00e-62	231.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	51.52	3.00e-150	524.00
IUUC-Kpa-049135	Komagataella pastoris	32.33	3.00e-64	238.00
IUUC-Lch-050537	Latimeria chalumnae	51.80	2.00e-152	531.00
IUUC-Lpe-050969	Leersia perrieri	34.95	6.00e-65	240.00
IUUC-Loc-052765	Lepisosteus oculatus	45.79	3.00e-126	444.00
IUUC-Lma-053105	Leptosphaeria maculans	32.73	8.00e-60	223.00
IUUC-Laf-053571	Loxodonta africana	52.95	1.00e-145	508.00
IUUC-Mcc-055166	Macaca mulatta	51.23	9.00e-150	522.00
IUUC-Mor-057103	Magnaporthe oryzae	30.70	2.00e-55	209.00
IUUC-Mpo-057621	Magnaporthe poae	30.11	8.00e-49	187.00
IUUC-Mtr-057769	Medicago truncatula	32.99	2.00e-74	273.00
IUUC-Mla-059185	Melampsora laricipopulina	28.07	5.00e-37	147.00
IUUC-Mga-059709	Meleagris gallopavo	51.68	7.00e-144	503.00
IUUC-Mvi-060530	Microbotryum violaceum	32.57	2.00e-54	206.00
IUUC-Mmr-060988	Microcebus murinus	51.13	3.00e-150	524.00
IUUC-Mdo-063065	Monodelphis domestica	51.80	7.00e-152	529.00
IUUC-Mmu-063829	Mus musculus	51.13	1.00e-149	522.00
IUUC-Mac-065419	Musa acuminata	34.49	3.00e-71	261.00
IUUC-Mpu-066687	Mustela putorius furo	51.80	1.00e-148	518.00
IUUC-Mlu-067330	Myotis lucifugus	50.00	2.00e-142	498.00
IUUC-Nfi-068423	Neosartorya fischeri	31.46	4.00e-57	214.00
IUUC-Ncr-068809	Neurospora crassa	31.59	3.00e-52	198.00
IUUC-Nle-069261	Nomascus leucogenys	48.30	3.00e-136	478.00
IUUC-Opr-070469	Ochotona princeps	44.34	6.00e-99	353.00
IUUC-Ont-071961	Oreochromis niloticus	49.91	8.00e-146	509.00
IUUC-Oan-073565	Ornithorhynchus anatinus	50.58	7.00e-143	499.00
IUUC-Ocu-074951	Oryctolagus cuniculus	49.72	4.00e-143	500.00
IUUC-Oba-075688	Oryza barthii	33.60	4.00e-65	241.00
IUUC-Obr-076652	Oryza brachyantha	36.78	3.00e-64	238.00
IUUC-Ogl-077910	Oryza glaberrima	32.94	1.00e-68	253.00
IUUC-Ogu-078479	Oryza glumaepatula	32.94	1.00e-68	253.00
IUUC-Oin-079697	Oryza indica	35.31	9.00e-66	243.00
IUUC-Olo-080811	Oryza longistaminata	37.13	2.00e-45	175.00
IUUC-Ome-081706	Oryza meridionalis	32.94	5.00e-68	251.00
IUUC-Oni-083070	Oryza nivara	32.75	2.00e-68	252.00
IUUC-Opu-083605	Oryza punctata	35.51	5.00e-58	217.00
IUUC-Oru-084522	Oryza rufipogon	32.94	1.00e-68	253.00
IUUC-Osa-085351	Oryza sativa	34.88	2.00e-66	246.00
IUUC-Ola-086743	Oryzias latipes	58.44	2.00e-128	451.00
IUUC-Olu-087695	Ostreococcus lucimarinus	30.90	8.00e-46	176.00
IUUC-Oga-089131	Otolemur garnettii	50.64	9.00e-150	523.00
IUUC-Oar-089319	Ovis aries	53.27	5.00e-145	506.00
IUUC-Ptr-090783	Pan troglodytes	52.75	1.00e-144	505.00
IUUC-Pan-092927	Papio anubis	51.23	1.00e-149	522.00
IUUC-Psi-093670	Pelodiscus sinensis	51.78	1.00e-143	502.00
IUUC-Pma-094323	Petromyzon marinus	45.22	9.00e-116	409.00
IUUC-Pno-095141	Phaeosphaeria nodorum	31.64	1.00e-51	196.00
IUUC-Ppa-095413	Physcomitrella patens	30.02	1.00e-67	249.00
IUUC-Pfo-096473	Poecilia formosa	51.04	2.00e-150	525.00
IUUC-Pab-097612	Pongo abelii	51.13	8.00e-150	522.00
IUUC-Pop-099558	Populus trichocarpa	33.33	8.00e-79	287.00
IUUC-Pca-100329	Procavia capensis	49.44	1.00e-140	492.00
IUUC-Ppe-102020	Prunus persica	34.32	2.00e-80	292.00
IUUC-Pva-102721	Pteropus vampyrus	47.46	2.00e-131	461.00
IUUC-Pte-104340	Pyrenophora teres	31.83	9.00e-52	197.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	32.95	3.00e-59	222.00
IUUC-Rno-105247	Rattus norvegicus	51.13	7.00e-150	523.00
IUUC-Sce-106247	Saccharomyces cerevisiae	30.57	9.00e-51	193.00
IUUC-Sha-107538	Sarcophilus harrisii	54.42	6.00e-64	235.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	31.39	3.00e-60	224.00
IUUC-Spo-108226	Schizosaccharomyces pombe	30.20	3.00e-54	204.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	29.85	5.00e-50	191.00
IUUC-Smo-109310	Selaginella moellendorffii	32.62	5.00e-78	284.00
IUUC-Sit-109716	Setaria italica	32.71	1.00e-68	253.00
IUUC-Sly-111077	Solanum lycopersicum	34.62	4.00e-65	241.00
IUUC-Stu-112203	Solanum tuberosum	37.08	3.00e-62	231.00
IUUC-Sar-113174	Sorex araneus	46.75	9.00e-123	432.00
IUUC-Sbi-114205	Sorghum bicolor	31.66	1.00e-67	249.00
IUUC-Ssc-115315	Sus scrofa	49.17	7.00e-143	499.00
IUUC-Tgu-116938	Taeniopygia guttata	53.07	1.00e-145	508.00
IUUC-Tru-118304	Takifugu rubripes	50.46	3.00e-149	521.00
IUUC-Tsy-119413	Tarsius syrichta	44.28	5.00e-123	434.00
IUUC-Tni-120119	Tetraodon nigroviridis	52.36	2.00e-151	528.00
IUUC-Tca-121716	Theobroma cacao	34.77	8.00e-78	283.00
IUUC-Tre-122139	Trichoderma reesei	30.48	1.00e-47	182.00
IUUC-Tvi-122599	Trichoderma virens	29.83	5.00e-49	187.00
IUUC-Tae-125608	Triticum aestivum	32.88	1.00e-72	266.00
IUUC-Tme-127115	Tuber melanosporum	31.81	2.00e-64	239.00
IUUC-Ttr-129006	Tursiops truncatus	49.52	2.00e-138	484.00
IUUC-Vda-129829	Verticillium dahliae	33.01	2.00e-33	135.00
IUUC-Vvi-131477	Vitis vinifera	33.21	1.00e-64	240.00
IUUC-Xtr-132444	Xenopus tropicalis	50.55	2.00e-150	525.00
IUUC-Xma-133514	Xiphophorus maculatus	51.61	3.00e-150	524.00
IUUC-Yli-134357	Yarrowia lipolytica	31.23	4.00e-45	174.00
IUUC-Zma-134945	Zea mays	31.84	2.00e-66	246.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence