• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
UUCD2 ID IUUC-Dre-028575
UUCD1 version UUC-DaR-01419
Ensembl Protein ID ENSDARP00000086546.4
UniProt Accession A0JMQ9; ZRN1B_DANRE
Genbank Protein ID AAI25973.1
Protein Name Ubiquitin thioesterase zranb1-B; Zinc finger Ran-binding domain-containing protein 1-B
Genbank Nucleotide ID BC125972
Gene Name zranb1b; zranb1; zgc:154177
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000063190.4 ENSDART00000092113.4 ENSDARP00000086546.4
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/OTU 6.30e-34 118.2 440 600
UBD/ZnF/NZF 4.60e-30 103.7 154 180
Active Site
Position(s) Description Evidence
451 Nucleophile ECO:0000250}
593 Proton acceptor ECO:0000250}
Domain Profile

   DUB/OTU
   S: 1    llilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeak 76
           l++l+++++G+CLl++v q+++g++d+ds l++ l ++L++ +s+++    +++++++s+++  +        +++++f+ +l+++++ 
   Q: 440  LYALWNRTAGDCLLDSVLQATWGIYDKDSvLRKSLNDSLHD-CSHWFytrwKEWESWYSQSFGLHfslreeqwQEDWAFILSLASQPGA 527
           6899*************************************.*****999999999999999999**********************77 PP
   S: 77   .geeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYdaLval 138
             e++h+f+La+iL+rpiiv+ v++++s         +++g++lpll++++  +k+pi+L+Y++gH++aLva+
   Q: 528  sLEQTHVFVLAHILRRPIIVYGVKYYKSfrgetlgytRFQGVYLPLLWEQSFcWKSPIALGYTRGHFSALVAM 600
           46********************************************************************986 PP
   

   UBD/ZnF/NZF
   S: 3    aqWaCsaCTflNePeavkCemCsrpRg 29
           + W CsaCT++N+P +++C++C++p++
   Q: 154  QRWPCSACTYENWPKSLRCVVCDHPKP 180
           89************************8 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. May play a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity).
 Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. May play a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity).
Protein Sequence
(Fasta)
MTDLGLKWSC EYCTYENWPS AIKCTMCRAQ RHNAPIITEE PFKSSSSLDP SLCTTQGGST 60
LLICPDSSAR PRVRIADELP ETSSKWSCHM CTYLNWPRAI RCTQCLSQRQ QGSQQHSPLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-028575|DUB,OTU;UBD,NZF|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGAGGATGAC AGATCTGGGC TTGAAGTGGA GCTGTGAGTA CTGCACCTAC GAGAACTGGC 60
CGTCTGCTAT CAAATGCACC ATGTGTCGGG CACAAAGGCA CAACGCACCC ATCATCACAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-028575|DUB,OTU;UBD,NZF|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003323--OTU_dom
IPR001876--Znf_RanBP2
PROSITE

PS50802--OTU
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF02338--OTU
PF00641--zf-RanBP
SMART

SM00547--ZnF_RBZ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0007420--P:brain development
GO:0016477--P:cell migration
GO:0021551--P:central nervous system morphogenesis
GO:0007010--P:cytoskeleton organization
GO:0030177--P:positive regulation of Wnt signaling pathway
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035523--P:protein K29-linked deubiquitination
GO:1990168--P:protein K33-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0022604--P:regulation of cell morphogenesis
GO:0016055--P:Wnt signaling pathway
KEGG dre:777720
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002329 Ailuropoda melanoleuca 77.96 0.00e+00 1132.00
IUUC-Apl-003612 Anas platyrhynchos 78.33 0.00e+00 1147.00
IUUC-Aca-004604 Anolis carolinensis 78.24 0.00e+00 1113.00
IUUC-Ame-011865 Astyanax mexicanus 86.60 0.00e+00 1239.00
IUUC-Bta-012482 Bos taurus 78.24 0.00e+00 1135.00
IUUC-Cja-019268 Callithrix jacchus 78.38 0.00e+00 1137.00
IUUC-Cfa-021066 Canis familiaris 78.03 0.00e+00 1137.00
IUUC-Cpo-021479 Cavia porcellus 77.51 0.00e+00 1142.00
IUUC-Csa-023512 Chlorocebus sabaeus 78.38 0.00e+00 1137.00
IUUC-Cho-024615 Choloepus hoffmanni 72.71 0.00e+00 930.00
IUUC-Dno-029309 Dasypus novemcinctus 76.77 0.00e+00 1119.00
IUUC-Dor-030895 Dipodomys ordii 90.95 4.00e-124 438.00
IUUC-Dme-032064 Drosophila melanogaster 50.36 4.00e-141 495.00
IUUC-Ete-032769 Echinops telfairi 77.55 0.00e+00 1132.00
IUUC-Eca-033523 Equus caballus 78.10 0.00e+00 1134.00
IUUC-Eeu-034672 Erinaceus europaeus 76.59 0.00e+00 929.00
IUUC-Fca-036567 Felis catus 77.68 0.00e+00 1133.00
IUUC-Fal-037545 Ficedula albicollis 78.80 0.00e+00 1152.00
IUUC-Gmo-038762 Gadus morhua 80.43 0.00e+00 1148.00
IUUC-Gga-040857 Gallus gallus 78.80 0.00e+00 1154.00
IUUC-Gac-042178 Gasterosteus aculeatus 79.51 0.00e+00 1165.00
IUUC-Ggo-045078 Gorilla gorilla 78.52 0.00e+00 1138.00
IUUC-Hsa-046882 Homo sapiens 78.38 0.00e+00 1138.00
IUUC-Itr-048983 Ictidomys tridecemlineatus 91.57 0.00e+00 859.00
IUUC-Lch-050317 Latimeria chalumnae 78.46 0.00e+00 1101.00
IUUC-Loc-052922 Lepisosteus oculatus 80.59 0.00e+00 1162.00
IUUC-Laf-054134 Loxodonta africana 77.96 0.00e+00 1130.00
IUUC-Mcc-054889 Macaca mulatta 78.73 0.00e+00 1132.00
IUUC-Meu-056035 Macropus eugenii 77.89 0.00e+00 1111.00
IUUC-Mor-057018 Magnaporthe oryzae 27.08 8.00e-06 45.40
IUUC-Mga-059653 Meleagris gallopavo 74.79 0.00e+00 1079.00
IUUC-Mmr-061487 Microcebus murinus 78.24 0.00e+00 1136.00
IUUC-Mdo-061945 Monodelphis domestica 78.30 0.00e+00 1137.00
IUUC-Mmu-063923 Mus musculus 78.10 0.00e+00 1135.00
IUUC-Mpu-066044 Mustela putorius furo 78.10 0.00e+00 1133.00
IUUC-Mlu-067031 Myotis lucifugus 77.25 0.00e+00 1088.00
IUUC-Nle-069600 Nomascus leucogenys 78.38 0.00e+00 1136.00
IUUC-Opr-070795 Ochotona princeps 71.07 0.00e+00 954.00
IUUC-Ont-071506 Oreochromis niloticus 77.28 0.00e+00 1162.00
IUUC-Oan-072942 Ornithorhynchus anatinus 91.03 6.00e-158 550.00
IUUC-Ocu-074481 Oryctolagus cuniculus 74.14 0.00e+00 1075.00
IUUC-Ola-087151 Oryzias latipes 79.95 0.00e+00 1145.00
IUUC-Oga-089035 Otolemur garnettii 78.19 0.00e+00 1137.00
IUUC-Oar-089948 Ovis aries 78.13 0.00e+00 1133.00
IUUC-Ptr-091245 Pan troglodytes 78.52 0.00e+00 1138.00
IUUC-Pan-092797 Papio anubis 72.18 0.00e+00 698.00
IUUC-Psi-093759 Pelodiscus sinensis 71.26 0.00e+00 679.00
IUUC-Pfo-096771 Poecilia formosa 76.86 0.00e+00 1139.00
IUUC-Pab-098015 Pongo abelii 78.38 0.00e+00 1137.00
IUUC-Pca-100282 Procavia capensis 77.10 0.00e+00 1014.00
IUUC-Pva-102680 Pteropus vampyrus 77.90 0.00e+00 1028.00
IUUC-Pgr-103642 Puccinia graminis 24.22 2.00e-03 37.40
IUUC-Rno-105058 Rattus norvegicus 78.10 0.00e+00 1135.00
IUUC-Sha-106846 Sarcophilus harrisii 77.92 0.00e+00 1132.00
IUUC-Stu-112451 Solanum tuberosum 38.89 8.50e-02 32.00
IUUC-Sar-113395 Sorex araneus 56.55 4.00e-72 266.00
IUUC-Ssc-116143 Sus scrofa 78.24 0.00e+00 1135.00
IUUC-Tgu-117173 Taeniopygia guttata 78.94 0.00e+00 1154.00
IUUC-Tru-118042 Takifugu rubripes 78.74 0.00e+00 1162.00
IUUC-Tsy-118947 Tarsius syrichta 71.41 0.00e+00 981.00
IUUC-Tni-120090 Tetraodon nigroviridis 76.35 0.00e+00 1098.00
IUUC-Tbe-127522 Tupaia belangeri 90.35 0.00e+00 804.00
IUUC-Ttr-128170 Tursiops truncatus 78.10 0.00e+00 1133.00
IUUC-Uma-129542 Ustilago maydis 50.00 3.40e-01 30.00
IUUC-Vpa-130143 Vicugna pacos 70.58 0.00e+00 908.00
IUUC-Xtr-132143 Xenopus tropicalis 77.54 0.00e+00 1095.00
IUUC-Xma-133323 Xiphophorus maculatus 79.29 0.00e+00 1164.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved