• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
UUCD2 ID IUUC-Dre-027799
UUCD1 version UUC-DaR-01424
Ensembl Protein ID ENSDARP00000003565.6
UniProt Accession Q567B1; OTU1_DANRE
Genbank Protein ID AAH93247.1
Protein Name Ubiquitin thioesterase OTU1
Genbank Nucleotide ID BC093247
Gene Name yod1; zgc:112182
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000008542.7 ENSDART00000023388.7 ENSDARP00000003565.6
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UBQ/UBQ_Other 3.90e-06 27.6 20 78
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 19   psdtVaeLKekiekklgippeqqrLiykGki....L.eddktLadyglkdgstihllek 72
            +++V+eLK+kie+++gip++ q++++   +    L      L+dy +k g+t++++e+
   Q: 20   HQSCVQELKDKIEELTGIPCDVQKIMVGYPPssldLrNGEAHLKDYPIKSGDTLIVEEE 78
           5679***********************733355445556678************99876 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin (By similarity).
 Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin (By similarity).
Protein Sequence
(Fasta)
MLRLRCKAKN GTHLMQGLTH QSCVQELKDK IEELTGIPCD VQKIMVGYPP SSLDLRNGEA 60
HLKDYPIKSG DTLIVEEEKN KPKPPVQPTV TKGPSFEVTP VVERRVVPAD NSCLFTSVNY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-027799|ULD,UBQ_Other|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCTCTCAAA AAGTCCTTTG ATGACAAAAA CTTTCGACCA TGGTCTTTAT ACCGGTTTCA 60
ATCAGCATTT ACCCTTAGAG TTTCATTTAA ACGCTTTATT ACATTAAAAA GTACAGCTAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-027799|ULD,UBQ_Other|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003323--OTU_dom
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50802--OTU
PS50053--UBIQUITIN_2
PS00028--ZINC_FINGER_C2H2_1
Pfam

PF02338--OTU
PF14560--Ubiquitin_2
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:1990167--P:protein K27-linked deubiquitination
GO:0035523--P:protein K29-linked deubiquitination
GO:1990168--P:protein K33-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG dre:550411
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000271 Aegilops tauschii 51.04 4.00e-48 184.00
IUUC-Aml-001860 Ailuropoda melanoleuca 71.80 9.00e-128 449.00
IUUC-Atr-002548 Amborella trichopoda 53.30 2.00e-58 218.00
IUUC-Apl-004025 Anas platyrhynchos 79.75 4.00e-102 363.00
IUUC-Aca-004505 Anolis carolinensis 71.38 1.00e-129 455.00
IUUC-Aly-005999 Arabidopsis lyrata 47.57 6.00e-50 190.00
IUUC-Ath-006774 Arabidopsis thaliana 48.54 1.00e-50 192.00
IUUC-Ago-007741 Ashbya gossypii 33.55 3.00e-44 172.00
IUUC-Acl-008278 Aspergillus clavatus 34.43 2.00e-47 182.00
IUUC-Afl-008710 Aspergillus flavus 34.82 2.00e-47 182.00
IUUC-Afu-009009 Aspergillus fumigatus 43.96 1.00e-45 177.00
IUUC-Ani-009430 Aspergillus nidulans 33.23 9.00e-45 174.00
IUUC-Ang-009508 Aspergillus niger 33.90 2.00e-38 152.00
IUUC-Aor-009992 Aspergillus oryzae 34.82 3.00e-47 182.00
IUUC-Ate-010440 Aspergillus terreus 34.62 3.00e-46 179.00
IUUC-Ame-011038 Astyanax mexicanus 89.04 7.00e-163 566.00
IUUC-Bgr-012262 Blumeria graminis 28.41 3.00e-37 149.00
IUUC-Bta-012864 Bos taurus 71.48 5.00e-128 450.00
IUUC-Bci-013986 Botrytis cinerea 35.96 8.00e-37 147.00
IUUC-Bdi-014194 Brachypodium distachyon 52.17 4.00e-54 204.00
IUUC-Bol-016166 Brassica oleracea 48.79 4.00e-51 194.00
IUUC-Bra-017783 Brassica rapa 49.76 7.00e-52 196.00
IUUC-Cja-019488 Callithrix jacchus 71.48 5.00e-127 447.00
IUUC-Cpo-021728 Cavia porcellus 71.62 3.00e-128 451.00
IUUC-Cre-022819 Chlamydomonas reinhardtii 48.78 7.00e-45 173.00
IUUC-Csa-024237 Chlorocebus sabaeus 71.29 1.00e-125 442.00
IUUC-Cho-024544 Choloepus hoffmanni 70.63 4.00e-126 444.00
IUUC-Cin-025549 Ciona intestinalis 47.21 1.00e-75 276.00
IUUC-Cgl-026552 Colletotrichum gloeosporioides 32.54 6.00e-37 148.00
IUUC-Cne-027022 Cryptococcus neoformans 44.83 3.00e-45 175.00
IUUC-Cme-027196 Cyanidioschyzon merolae 34.77 3.00e-42 165.00
IUUC-Dno-029863 Dasypus novemcinctus 69.51 9.00e-125 439.00
IUUC-Dor-030804 Dipodomys ordii 66.56 9.00e-115 406.00
IUUC-Dse-031494 Dothistroma septosporum 42.31 1.00e-40 160.00
IUUC-Dme-032065 Drosophila melanogaster 41.91 9.00e-72 263.00
IUUC-Ete-033193 Echinops telfairi 69.31 9.00e-124 436.00
IUUC-Eca-033993 Equus caballus 71.15 1.00e-126 446.00
IUUC-Fca-035949 Felis catus 72.13 2.00e-128 452.00
IUUC-Fal-037473 Ficedula albicollis 78.06 1.00e-101 362.00
IUUC-Fox-037779 Fusarium oxysporum 30.94 4.00e-29 122.00
IUUC-Fso-038370 Fusarium solani 28.21 3.00e-26 112.00
IUUC-Gmo-038778 Gadus morhua 71.05 1.00e-114 405.00
IUUC-Ggr-039940 Gaeumannomyces graminis 32.30 2.00e-36 145.00
IUUC-Gga-041102 Gallus gallus 67.30 2.00e-122 431.00
IUUC-Gac-041954 Gasterosteus aculeatus 86.51 2.00e-156 544.00
IUUC-Gma-043608 Glycine max 48.79 2.00e-53 201.00
IUUC-Ggo-044753 Gorilla gorilla 70.63 3.00e-124 438.00
IUUC-Hsa-045714 Homo sapiens 69.90 4.00e-117 414.00
IUUC-Hvu-047600 Hordeum vulgare 51.44 5.00e-54 203.00
IUUC-Itr-048026 Ictidomys tridecemlineatus 71.15 2.00e-127 449.00
IUUC-Kpa-049360 Komagataella pastoris 30.41 5.00e-39 154.00
IUUC-Lch-049900 Latimeria chalumnae 78.10 1.00e-131 462.00
IUUC-Lpe-050984 Leersia perrieri 43.00 4.00e-37 147.00
IUUC-Loc-052567 Lepisosteus oculatus 84.26 7.00e-156 543.00
IUUC-Lma-053247 Leptosphaeria maculans 33.43 6.00e-44 171.00
IUUC-Laf-053361 Loxodonta africana 69.97 1.00e-125 442.00
IUUC-Meu-056137 Macropus eugenii 67.11 1.00e-112 399.00
IUUC-Mor-057191 Magnaporthe oryzae 30.29 4.00e-29 122.00
IUUC-Mpo-057565 Magnaporthe poae 31.46 3.00e-32 132.00
IUUC-Mtr-058196 Medicago truncatula 50.72 3.00e-53 201.00
IUUC-Mla-059096 Melampsora laricipopulina 42.71 1.00e-41 164.00
IUUC-Mga-059489 Meleagris gallopavo 80.00 2.00e-108 385.00
IUUC-Mvi-060300 Microbotryum violaceum 38.86 6.00e-39 154.00
IUUC-Mmr-061618 Microcebus murinus 69.84 1.00e-121 429.00
IUUC-Mdo-061909 Monodelphis domestica 73.68 1.00e-129 456.00
IUUC-Mmu-063434 Mus musculus 69.84 5.00e-126 444.00
IUUC-Mac-064676 Musa acuminata 51.69 1.00e-54 206.00
IUUC-Mpu-066733 Mustela putorius furo 71.48 2.00e-127 448.00
IUUC-Mlu-066990 Myotis lucifugus 68.75 1.00e-123 436.00
IUUC-Nfi-068249 Neosartorya fischeri 33.72 2.00e-44 172.00
IUUC-Ncr-068764 Neurospora crassa 34.26 1.00e-38 153.00
IUUC-Nle-069094 Nomascus leucogenys 70.63 4.00e-124 437.00
IUUC-Oan-073585 Ornithorhynchus anatinus 72.79 2.00e-128 451.00
IUUC-Oba-075949 Oryza barthii 51.92 4.00e-54 204.00
IUUC-Obr-076096 Oryza brachyantha 52.17 1.00e-54 205.00
IUUC-Ogl-077106 Oryza glaberrima 51.44 1.00e-53 202.00
IUUC-Ogu-078024 Oryza glumaepatula 51.92 7.00e-54 203.00
IUUC-Oin-079635 Oryza indica 51.44 9.00e-54 202.00
IUUC-Olo-080299 Oryza longistaminata 51.92 8.00e-54 203.00
IUUC-Ome-081359 Oryza meridionalis 51.92 4.00e-54 204.00
IUUC-Oni-082459 Oryza nivara 51.44 1.00e-53 202.00
IUUC-Opu-083167 Oryza punctata 53.37 2.00e-55 209.00
IUUC-Oru-084577 Oryza rufipogon 51.44 9.00e-54 202.00
IUUC-Osa-085746 Oryza sativa 56.86 2.00e-13 66.60
IUUC-Ola-086890 Oryzias latipes 88.70 2.00e-160 558.00
IUUC-Olu-087585 Ostreococcus lucimarinus 42.21 2.00e-43 168.00
IUUC-Oga-088190 Otolemur garnettii 70.30 4.00e-125 441.00
IUUC-Oar-089631 Ovis aries 72.13 3.00e-128 451.00
IUUC-Pan-091892 Papio anubis 71.29 5.00e-125 440.00
IUUC-Pma-094491 Petromyzon marinus 56.73 8.00e-88 317.00
IUUC-Pno-094993 Phaeosphaeria nodorum 34.65 8.00e-46 177.00
IUUC-Ppa-095791 Physcomitrella patens 53.40 4.00e-55 207.00
IUUC-Pfo-096301 Poecilia formosa 87.04 1.00e-158 551.00
IUUC-Pab-097873 Pongo abelii 71.29 5.00e-125 441.00
IUUC-Pop-099482 Populus trichocarpa 50.24 9.00e-55 206.00
IUUC-Pca-100817 Procavia capensis 67.99 1.00e-116 412.00
IUUC-Ppe-101624 Prunus persica 53.40 1.00e-56 212.00
IUUC-Pva-102120 Pteropus vampyrus 70.49 3.00e-126 444.00
IUUC-Pgr-103368 Puccinia graminis 39.62 4.00e-42 165.00
IUUC-Ptt-103923 Puccinia triticina 39.91 2.00e-43 169.00
IUUC-Pte-104199 Pyrenophora teres 40.80 3.00e-42 166.00
IUUC-Pyt-104502 Pyrenophora triticirepentis 32.53 1.00e-44 173.00
IUUC-Rno-105605 Rattus norvegicus 69.97 4.00e-126 444.00
IUUC-Sce-106323 Saccharomyces cerevisiae 31.06 1.00e-33 137.00
IUUC-Sha-107176 Sarcophilus harrisii 75.29 3.00e-115 407.00
IUUC-Sja-107812 Schizosaccharomyces japonicus 40.20 2.00e-40 159.00
IUUC-Spo-108085 Schizosaccharomyces pombe 33.53 5.00e-46 178.00
IUUC-Smo-109050 Selaginella moellendorffii 51.21 2.00e-54 205.00
IUUC-Sit-110056 Setaria italica 50.24 4.00e-54 204.00
IUUC-Sly-111869 Solanum lycopersicum 49.47 8.00e-45 172.00
IUUC-Stu-112452 Solanum tuberosum 50.98 7.00e-53 199.00
IUUC-Sar-113629 Sorex araneus 71.31 4.00e-48 185.00
IUUC-Sbi-114422 Sorghum bicolor 51.69 3.00e-55 207.00
IUUC-Sre-115105 Sporisorium reilianum 42.08 1.00e-33 137.00
IUUC-Ssc-115553 Sus scrofa 71.48 1.00e-127 449.00
IUUC-Tgu-116921 Taeniopygia guttata 75.11 3.00e-101 360.00
IUUC-Tru-117830 Takifugu rubripes 85.71 4.00e-156 543.00
IUUC-Tsy-119320 Tarsius syrichta 71.29 3.00e-125 441.00
IUUC-Tni-119706 Tetraodon nigroviridis 83.06 1.00e-147 515.00
IUUC-Tca-121238 Theobroma cacao 50.72 2.00e-54 204.00
IUUC-Tae-124711 Triticum aestivum 42.11 4.00e-55 208.00
IUUC-Tme-126966 Tuber melanosporum 36.45 4.00e-53 201.00
IUUC-Tbe-127712 Tupaia belangeri 74.00 1.00e-83 302.00
IUUC-Ttr-129168 Tursiops truncatus 69.84 2.00e-126 445.00
IUUC-Uma-129461 Ustilago maydis 41.95 1.00e-39 157.00
IUUC-Vda-129890 Verticillium dahliae 35.56 2.00e-24 105.00
IUUC-Vpa-130616 Vicugna pacos 71.15 4.00e-127 447.00
IUUC-Vvi-131250 Vitis vinifera 53.14 7.00e-56 209.00
IUUC-Xtr-132126 Xenopus tropicalis 72.37 3.00e-131 461.00
IUUC-Xma-133596 Xiphophorus maculatus 87.38 2.00e-158 551.00
IUUC-Yli-134562 Yarrowia lipolytica 35.49 3.00e-37 149.00
IUUC-Zma-135205 Zea mays 50.24 1.00e-53 202.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved