iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-073891

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AAGW02012173

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000001081.2	ENSOCUT00000001083.2	ENSOCUP00000000938.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.70e-135	450.0	584	917

Active Site

Position(s)	Description	Evidence
886	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 584  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 671
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++   ++iee+gl++ f+v+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 672  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWISRD--NNIEECGLEMYFCVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 758
           ***********************************76..7************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 759  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 846
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 847  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 917
           *********************************************************************96 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGES KKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF RVWSHHTLKA DALLGRATID LKQALLAHNR KLERVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACTG CTTCACCAAG GTCTGATACT AGTAATAATC ACAGTGGAAG GTTGCAGTTA 60
CAGGTAACTG GTAAGTTATT TTCATTATAA CTTTATTTAA TATGGCGAGT CCCTGGTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	90.03	0.00e+00	1645.00
IUUC-Apl-003310	Anas platyrhynchos	80.00	0.00e+00	1454.00
IUUC-Aca-005388	Anolis carolinensis	78.00	0.00e+00	1384.00
IUUC-Ame-010992	Astyanax mexicanus	84.56	0.00e+00	746.00
IUUC-Bta-012857	Bos taurus	88.41	0.00e+00	1607.00
IUUC-Cja-019448	Callithrix jacchus	90.90	0.00e+00	1674.00
IUUC-Cfa-020728	Canis familiaris	90.25	0.00e+00	1640.00
IUUC-Cpo-021635	Cavia porcellus	85.84	0.00e+00	1589.00
IUUC-Csa-023805	Chlorocebus sabaeus	90.51	0.00e+00	1240.00
IUUC-Cho-024943	Choloepus hoffmanni	77.95	0.00e+00	1098.00
IUUC-Dre-028245	Danio rerio	69.13	0.00e+00	1139.00
IUUC-Dno-029618	Dasypus novemcinctus	90.36	0.00e+00	1644.00
IUUC-Ete-032779	Echinops telfairi	88.75	0.00e+00	1020.00
IUUC-Eca-033313	Equus caballus	88.19	0.00e+00	1575.00
IUUC-Eeu-035259	Erinaceus europaeus	80.72	0.00e+00	1451.00
IUUC-Fca-035420	Felis catus	88.62	0.00e+00	1622.00
IUUC-Fal-037335	Ficedula albicollis	79.25	0.00e+00	1428.00
IUUC-Gmo-039172	Gadus morhua	81.02	0.00e+00	960.00
IUUC-Gga-040246	Gallus gallus	79.81	0.00e+00	1442.00
IUUC-Gac-042211	Gasterosteus aculeatus	86.64	0.00e+00	1070.00
IUUC-Ggo-045001	Gorilla gorilla	89.90	0.00e+00	1476.00
IUUC-Hsa-046544	Homo sapiens	90.47	0.00e+00	1669.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	89.46	0.00e+00	1617.00
IUUC-Lch-050398	Latimeria chalumnae	73.35	0.00e+00	1290.00
IUUC-Loc-052116	Lepisosteus oculatus	73.00	0.00e+00	1305.00
IUUC-Laf-053551	Loxodonta africana	87.99	0.00e+00	1590.00
IUUC-Meu-056455	Macropus eugenii	62.96	0.00e+00	745.00
IUUC-Mga-059986	Meleagris gallopavo	79.61	0.00e+00	1451.00
IUUC-Mmr-060945	Microcebus murinus	88.10	0.00e+00	1603.00
IUUC-Mdo-063024	Monodelphis domestica	67.01	0.00e+00	1221.00
IUUC-Mmu-063202	Mus musculus	87.30	0.00e+00	1548.00
IUUC-Mpu-065773	Mustela putorius furo	89.30	0.00e+00	1622.00
IUUC-Mlu-067373	Myotis lucifugus	97.11	0.00e+00	656.00
IUUC-Nle-069188	Nomascus leucogenys	90.90	0.00e+00	1675.00
IUUC-Opr-070965	Ochotona princeps	86.54	0.00e+00	1555.00
IUUC-Ont-072226	Oreochromis niloticus	87.01	0.00e+00	1077.00
IUUC-Oan-073497	Ornithorhynchus anatinus	82.58	0.00e+00	1441.00
IUUC-Ola-087438	Oryzias latipes	84.51	0.00e+00	1076.00
IUUC-Oga-087922	Otolemur garnettii	89.51	0.00e+00	1625.00
IUUC-Oar-089317	Ovis aries	88.00	0.00e+00	1575.00
IUUC-Ptr-090484	Pan troglodytes	90.36	0.00e+00	1669.00
IUUC-Pan-092117	Papio anubis	90.57	0.00e+00	1672.00
IUUC-Psi-093338	Pelodiscus sinensis	80.63	0.00e+00	1463.00
IUUC-Pfo-096171	Poecilia formosa	87.35	0.00e+00	1078.00
IUUC-Pab-098654	Pongo abelii	87.88	0.00e+00	1199.00
IUUC-Pva-102811	Pteropus vampyrus	76.60	0.00e+00	1325.00
IUUC-Rno-106125	Rattus norvegicus	87.19	0.00e+00	1563.00
IUUC-Sha-107243	Sarcophilus harrisii	69.43	0.00e+00	1292.00
IUUC-Ssc-115368	Sus scrofa	89.63	0.00e+00	1618.00
IUUC-Tgu-117079	Taeniopygia guttata	79.22	0.00e+00	1417.00
IUUC-Tru-118062	Takifugu rubripes	68.25	0.00e+00	1250.00
IUUC-Tsy-119507	Tarsius syrichta	84.62	0.00e+00	1531.00
IUUC-Tni-120151	Tetraodon nigroviridis	86.50	0.00e+00	1066.00
IUUC-Ttr-129260	Tursiops truncatus	83.64	0.00e+00	1485.00
IUUC-Vpa-130390	Vicugna pacos	82.71	0.00e+00	924.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence