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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045670
Ensembl Protein ID ENSP00000340836.6
UniProt Accession Q92882; Q5W126; Q96IJ4; OSTF1_HUMAN
Genbank Protein ID AAB06396.1; BAD96316.1; AAH07459.1
Protein Name Osteoclast-stimulating factor 1
Genbank Nucleotide ID U63717; AK222596; AL133548
Gene Name OSTF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000134996.11 ENST00000346234.6 ENSP00000340836.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.20e-14 54.8 14 68
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +++++ly +e+ + deL +++Gd++++   +  d +W+kg  + +g+ Gl+P+n+v++
   Q: 14   VKVFRALYTFEPRTPDELYFEEGDIIYIT--DMSDTNWWKG--TSKGRTGLIPSNYVAE 68
           57899***********************7..99********..89************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
 Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
Protein Sequence
(Fasta)
MSKPPPKPVK PGQVKVFRAL YTFEPRTPDE LYFEEGDIIY ITDMSDTNWW KGTSKGRTGL 60
IPSNYVAEQA ESIDNPLHEA AKRGNLSWLR ECLDNRVGVN GLDKAGSTAL YWACHGGHKD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045670|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCTTCCCGC AGCCAAGGGT GGGCGCCGGT CCTAGGAGGC GCACGGTTGT AAGCCAGACA 60
AAAAGAACTG GGGTGCCCGG AGTGCCAGGT GGCGGGCAAG CGGTGGGCTT TTCGGCGGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045670|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001452--SH3_domain
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50002--SH3
Pfam

PF12796--Ank_2
PF00018--SH3_1
PRINTS

PR01415--ANKYRIN
PR00452--SH3DOMAIN
SMART

SM00248--ANK
SM00326--SH3
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:1904813--C:ficolin-1-rich granule lumen
GO:0005622--C:intracellular
GO:0034774--C:secretory granule lumen
GO:0043312--P:neutrophil degranulation
GO:0001503--P:ossification
GO:0007165--P:signal transduction
KEGG hsa:26578
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001728 Ailuropoda melanoleuca 95.96 1.00e-112 399.00
IUUC-Apl-003751 Anas platyrhynchos 86.96 2.00e-104 371.00
IUUC-Aca-004876 Anolis carolinensis 90.65 8.00e-110 389.00
IUUC-Bta-012630 Bos taurus 96.97 2.00e-113 400.00
IUUC-Cel-018470 Caenorhabditis elegans 49.27 1.00e-50 192.00
IUUC-Cja-019917 Callithrix jacchus 98.99 3.00e-115 407.00
IUUC-Cfa-020190 Canis familiaris 96.81 1.00e-106 378.00
IUUC-Cpo-021650 Cavia porcellus 94.95 6.00e-111 392.00
IUUC-Csa-023311 Chlorocebus sabaeus 99.49 5.00e-116 409.00
IUUC-Cho-025043 Choloepus hoffmanni 87.62 2.00e-102 365.00
IUUC-Cin-025298 Ciona intestinalis 55.88 3.00e-53 201.00
IUUC-Csv-025890 Ciona savignyi 56.65 4.00e-60 224.00
IUUC-Dre-028036 Danio rerio 81.22 3.00e-99 354.00
IUUC-Dno-029567 Dasypus novemcinctus 97.47 3.00e-114 403.00
IUUC-Dor-031060 Dipodomys ordii 96.97 7.00e-113 399.00
IUUC-Eca-034406 Equus caballus 99.01 3.00e-118 417.00
IUUC-Fca-036234 Felis catus 97.21 2.00e-102 364.00
IUUC-Fal-037466 Ficedula albicollis 90.19 3.00e-109 387.00
IUUC-Gmo-039340 Gadus morhua 78.04 9.00e-99 352.00
IUUC-Gga-041127 Gallus gallus 90.65 2.00e-109 388.00
IUUC-Gac-042291 Gasterosteus aculeatus 78.04 2.00e-97 348.00
IUUC-Ggo-045142 Gorilla gorilla 100.00 8.00e-117 412.00
IUUC-Lch-050433 Latimeria chalumnae 85.05 8.00e-104 369.00
IUUC-Loc-052660 Lepisosteus oculatus 83.18 6.00e-104 369.00
IUUC-Laf-053692 Loxodonta africana 96.10 8.00e-115 405.00
IUUC-Mcc-054763 Macaca mulatta 99.49 5.00e-116 409.00
IUUC-Mga-059479 Meleagris gallopavo 86.14 1.00e-101 361.00
IUUC-Mmr-061426 Microcebus murinus 98.48 8.00e-115 405.00
IUUC-Mdo-062513 Monodelphis domestica 94.95 2.00e-112 398.00
IUUC-Mmu-063898 Mus musculus 95.48 6.00e-111 392.00
IUUC-Mpu-066606 Mustela putorius furo 95.86 3.00e-96 344.00
IUUC-Mlu-068187 Myotis lucifugus 95.12 6.00e-114 402.00
IUUC-Nle-069167 Nomascus leucogenys 99.49 5.00e-116 409.00
IUUC-Opr-070908 Ochotona princeps 96.53 7.00e-115 405.00
IUUC-Ont-072428 Oreochromis niloticus 82.24 2.00e-102 365.00
IUUC-Oan-072823 Ornithorhynchus anatinus 94.15 4.00e-113 400.00
IUUC-Ocu-074375 Oryctolagus cuniculus 97.47 2.00e-113 401.00
IUUC-Ola-086922 Oryzias latipes 81.31 2.00e-101 360.00
IUUC-Oga-088253 Otolemur garnettii 97.98 1.00e-114 405.00
IUUC-Oar-090217 Ovis aries 97.55 4.00e-116 409.00
IUUC-Ptr-091605 Pan troglodytes 100.00 8.00e-117 412.00
IUUC-Pan-092701 Papio anubis 99.49 5.00e-116 409.00
IUUC-Psi-093852 Pelodiscus sinensis 92.52 4.00e-113 400.00
IUUC-Pfo-096294 Poecilia formosa 80.37 6.00e-101 359.00
IUUC-Pva-102840 Pteropus vampyrus 76.17 9.00e-85 306.00
IUUC-Rno-105149 Rattus norvegicus 95.45 9.00e-112 395.00
IUUC-Sha-106884 Sarcophilus harrisii 93.66 1.00e-113 402.00
IUUC-Sja-107861 Schizosaccharomyces japonicus 36.17 6.00e-10 56.60
IUUC-Ssc-115549 Sus scrofa 98.48 8.00e-115 405.00
IUUC-Tgu-116709 Taeniopygia guttata 90.19 3.00e-109 387.00
IUUC-Tru-118367 Takifugu rubripes 82.24 2.00e-102 365.00
IUUC-Tni-120613 Tetraodon nigroviridis 81.78 3.00e-101 360.00
IUUC-Tbe-128089 Tupaia belangeri 80.98 6.00e-82 296.00
IUUC-Vpa-130041 Vicugna pacos 77.07 1.00e-81 295.00
IUUC-Xtr-132694 Xenopus tropicalis 84.16 6.00e-101 360.00
Created Date 25-Jun-2017

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