iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088362

Ensembl Protein ID

ENSOGAP00000018055.1

UniProt Accession

H0XPL4; H0XPL4_OTOGA

Genbank Protein ID

ENSOGAP00000018055

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03069736

Gene Name

ZNRF3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000031763.1	ENSOGAT00000027609.1	ENSOGAP00000018055.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	9.50e-06	26.1	193	234

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCle +   ++++v pC H fh++C+  w        ++ +CP Cr
   Q: 193  CAICLEKYidGEELRVIPCTHRFHRKCVDPW------LLQHHTCPHCR 234
           ********66334******************......9999******8 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MHPLGLCNNN DEEDLYEYGW VGVVKLEQPE LDRKPCLTVL GKAKRAVQRG ATAVIFDVSE 60
NPEAIDQLNQ ASEDPLKRPV VYVKGADAIK LMNIVNKQKV ARARIQHRPL RQPTEYFDMG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTCCTTCC ATTTTGTCTC CTAGATGCAC CCACTGGGCC TGTGTAATAA CAATGATGAA 60
GAGGACTTGT ATGAATATGG CTGGGTAGGA GTGGTAAAGC TGGAACAGCC GGAATTGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005887--C:integral component of plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:2000051--P:negative regulation of non-canonical Wnt signaling pathway
GO:0072089--P:stem cell proliferation
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0038018--P:Wnt receptor catabolic process
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001916	Ailuropoda melanoleuca	83.88	0.00e+00	1221.00
IUUC-Apl-004188	Anas platyrhynchos	71.86	0.00e+00	1035.00
IUUC-Aly-005850	Arabidopsis lyrata	42.68	4.00e-15	73.60
IUUC-Ath-007372	Arabidopsis thaliana	42.17	6.00e-15	73.20
IUUC-Ame-011764	Astyanax mexicanus	61.84	0.00e+00	731.00
IUUC-Bta-012478	Bos taurus	63.21	0.00e+00	638.00
IUUC-Bdi-014078	Brachypodium distachyon	62.79	2.00e-12	65.50
IUUC-Bol-016217	Brassica oleracea	56.25	4.00e-14	70.50
IUUC-Bra-017407	Brassica rapa	56.25	4.00e-14	70.50
IUUC-Cja-019504	Callithrix jacchus	88.00	0.00e+00	1328.00
IUUC-Cfa-020048	Canis familiaris	86.67	0.00e+00	1278.00
IUUC-Cpo-021725	Cavia porcellus	80.70	0.00e+00	1186.00
IUUC-Csa-023586	Chlorocebus sabaeus	87.62	0.00e+00	1274.00
IUUC-Cho-024867	Choloepus hoffmanni	91.18	0.00e+00	678.00
IUUC-Cin-025569	Ciona intestinalis	46.28	7.00e-54	205.00
IUUC-Csv-025869	Ciona savignyi	44.63	2.00e-47	183.00
IUUC-Dre-027553	Danio rerio	64.49	0.00e+00	796.00
IUUC-Dno-029370	Dasypus novemcinctus	83.76	0.00e+00	1201.00
IUUC-Dor-030816	Dipodomys ordii	78.68	0.00e+00	1100.00
IUUC-Ete-033060	Echinops telfairi	73.08	0.00e+00	838.00
IUUC-Eca-034044	Equus caballus	86.53	0.00e+00	1287.00
IUUC-Eeu-034591	Erinaceus europaeus	67.48	6.00e-138	484.00
IUUC-Fca-036000	Felis catus	85.44	0.00e+00	1287.00
IUUC-Fal-037147	Ficedula albicollis	70.34	0.00e+00	1040.00
IUUC-Gmo-039099	Gadus morhua	50.60	2.00e-122	432.00
IUUC-Gga-041243	Gallus gallus	68.48	0.00e+00	826.00
IUUC-Gac-041340	Gasterosteus aculeatus	49.14	4.00e-114	405.00
IUUC-Gma-044387	Glycine max	50.00	7.00e-15	73.90
IUUC-Ggo-044953	Gorilla gorilla	87.35	0.00e+00	1294.00
IUUC-Hsa-046484	Homo sapiens	88.16	0.00e+00	1309.00
IUUC-Itr-048470	Ictidomys tridecemlineatus	86.32	0.00e+00	1280.00
IUUC-Lch-050004	Latimeria chalumnae	58.66	0.00e+00	670.00
IUUC-Loc-051830	Lepisosteus oculatus	62.44	0.00e+00	778.00
IUUC-Laf-053975	Loxodonta africana	83.90	0.00e+00	1208.00
IUUC-Mcc-055302	Macaca mulatta	87.50	0.00e+00	1245.00
IUUC-Meu-056263	Macropus eugenii	75.76	0.00e+00	779.00
IUUC-Mtr-058744	Medicago truncatula	54.17	3.00e-13	68.20
IUUC-Mga-059706	Meleagris gallopavo	71.68	0.00e+00	1053.00
IUUC-Mmr-061372	Microcebus murinus	91.27	0.00e+00	1288.00
IUUC-Mdo-062651	Monodelphis domestica	64.64	0.00e+00	852.00
IUUC-Mmu-064339	Mus musculus	82.70	0.00e+00	1230.00
IUUC-Mac-065356	Musa acuminata	50.00	1.00e-12	67.40
IUUC-Mpu-066211	Mustela putorius furo	83.03	0.00e+00	1232.00
IUUC-Mlu-067058	Myotis lucifugus	84.97	0.00e+00	1199.00
IUUC-Nle-069886	Nomascus leucogenys	88.00	0.00e+00	1286.00
IUUC-Opr-070218	Ochotona princeps	81.36	0.00e+00	1090.00
IUUC-Ont-072483	Oreochromis niloticus	60.53	0.00e+00	769.00
IUUC-Oan-073718	Ornithorhynchus anatinus	71.61	0.00e+00	907.00
IUUC-Ocu-073847	Oryctolagus cuniculus	78.49	0.00e+00	1038.00
IUUC-Ogl-077034	Oryza glaberrima	45.71	2.00e-11	62.80
IUUC-Ogu-078680	Oryza glumaepatula	45.71	9.00e-12	64.30
IUUC-Oin-079182	Oryza indica	45.71	1.00e-11	63.50
IUUC-Opu-083306	Oryza punctata	67.44	8.00e-13	67.00
IUUC-Oru-084953	Oryza rufipogon	45.71	2.00e-11	63.50
IUUC-Osa-085734	Oryza sativa	45.71	2.00e-11	63.50
IUUC-Ola-087358	Oryzias latipes	62.32	0.00e+00	767.00
IUUC-Oar-090197	Ovis aries	97.97	3.00e-94	339.00
IUUC-Ptr-091350	Pan troglodytes	87.92	0.00e+00	1310.00
IUUC-Pan-091700	Papio anubis	87.62	0.00e+00	1241.00
IUUC-Psi-093301	Pelodiscus sinensis	71.36	0.00e+00	977.00
IUUC-Pfo-096917	Poecilia formosa	62.00	0.00e+00	759.00
IUUC-Pab-097932	Pongo abelii	88.00	0.00e+00	1311.00
IUUC-Pop-099640	Populus trichocarpa	57.14	2.00e-14	72.40
IUUC-Pca-101054	Procavia capensis	91.51	0.00e+00	947.00
IUUC-Pva-102879	Pteropus vampyrus	86.20	0.00e+00	1275.00
IUUC-Pgr-103476	Puccinia graminis	41.27	5.00e-09	55.10
IUUC-Sha-106507	Sarcophilus harrisii	54.18	2.00e-164	572.00
IUUC-Sit-110656	Setaria italica	67.44	7.00e-13	67.00
IUUC-Stu-112500	Solanum tuberosum	62.79	1.00e-12	65.90
IUUC-Sar-113182	Sorex araneus	80.57	6.00e-109	388.00
IUUC-Ssc-115966	Sus scrofa	80.87	0.00e+00	1059.00
IUUC-Tgu-116864	Taeniopygia guttata	63.39	0.00e+00	681.00
IUUC-Tru-118502	Takifugu rubripes	61.25	0.00e+00	734.00
IUUC-Tsy-119210	Tarsius syrichta	87.56	0.00e+00	1246.00
IUUC-Tni-120344	Tetraodon nigroviridis	51.62	2.00e-123	436.00
IUUC-Tca-120966	Theobroma cacao	48.39	4.00e-13	68.90
IUUC-Tbe-127735	Tupaia belangeri	86.24	9.00e-136	477.00
IUUC-Ttr-128714	Tursiops truncatus	73.71	0.00e+00	978.00
IUUC-Vvi-131280	Vitis vinifera	31.50	3.00e-13	69.70
IUUC-Xtr-132280	Xenopus tropicalis	59.25	0.00e+00	680.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence