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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045930
UUCD1 version UUC-HoS-00122
Ensembl Protein ID ENSP00000308944.5
UniProt Accession Q14527; D3DNH3; Q14536; Q16051; Q7KYJ6; Q86YA5; Q92652; Q96KM9; HLTF_HUMAN
Genbank Protein ID AAA67436.1; CAA86571.1; CAA86572.1; CAD10805.1; EAW78889.1; EAW78892.1; EAW78893.1; AAH44659.1; AAB27691.1
Protein Name Helicase-like transcription factor; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3
Genbank Nucleotide ID L34673; Z46606; Z46606; AJ418064; CH471052; CH471052; CH471052; BC044659; S64671
Gene Name HLTF; HIP116A; RNF80; SMARCA3; SNF2L3; ZBU1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000071794.15 ENST00000465259.5 ENSP00000420745.1
ENSG00000071794.15 ENST00000310053.9 ENSP00000308944.5
ENSG00000071794.15 ENST00000467858.1 ENSP00000420106.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18316726
Classification
Family E-value Score Start End
E3 activity/RING/RING 2.70e-06 29.5 760 801
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           CaiCl+++   p+++ C Hvf++ C+ q      ++++++++CPlCr
   Q: 760  CAICLDSLTV-PVITHCAHVFCKPCIcQV----IQNEQPHAKCPLCR 801
           ********88.999************444....599**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
 Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
Protein Sequence
(Fasta)
MSWMFKRDPV WKYLQTVQYG VHGNFPRLSY PTFFPRFEFQ DVIPPDDFLT SDEEVDSVLF 60
GSLRGHVVGL RYYTGVVNNN EMVALQRDPN NPYDKNAIKV NNVNGNQVGH LKKELAGALA 120
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Protein Fasta Sequence


>IUUC-Hsa-045930|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
ACAGAGCGAC GCTGGTCTCC CAGATTGTTG CAGAAGGAGA CGGCGTCGAC GTCTGACTGG 60
ACTCGCGGCG ACTTACCTTT CAGTCGTGCG CTCCTGATCC GGCGCTCGGA ATTTGTCCCC 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-045930|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0024--Alternative initiation
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0488--Methylation
KW-0511--Multifunctional enzyme
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0804--Transcription
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR014905--HIRAN
IPR030065--HLTF
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00271--Helicase_C
PF08797--HIRAN
PF00176--SNF2_N
SMART

SM00487--DEXDc
SM00490--HELICc
SM00910--HIRAN
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0003723--F:RNA binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0006301--P:postreplication repair
GO:0000209--P:protein polyubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
KEGG hsa:6596
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000167 Aegilops tauschii 38.41 1.00e-109 391.00
IUUC-Aml-001237 Ailuropoda melanoleuca 93.87 0.00e+00 1850.00
IUUC-Atr-003058 Amborella trichopoda 37.87 2.00e-108 387.00
IUUC-Aca-004994 Anolis carolinensis 65.86 0.00e+00 1248.00
IUUC-Aly-005898 Arabidopsis lyrata 42.07 3.00e-118 419.00
IUUC-Ath-007559 Arabidopsis thaliana 41.05 3.00e-119 422.00
IUUC-Ago-007997 Ashbya gossypii 33.95 8.00e-79 288.00
IUUC-Acl-008022 Aspergillus clavatus 30.33 8.00e-77 282.00
IUUC-Afl-008697 Aspergillus flavus 36.75 3.00e-85 310.00
IUUC-Afu-008767 Aspergillus fumigatus 35.83 7.00e-86 312.00
IUUC-Ani-009435 Aspergillus nidulans 34.92 2.00e-83 304.00
IUUC-Ang-009874 Aspergillus niger 34.02 6.00e-83 302.00
IUUC-Aor-010130 Aspergillus oryzae 37.24 8.00e-87 315.00
IUUC-Ate-010582 Aspergillus terreus 34.39 1.00e-78 288.00
IUUC-Ame-011743 Astyanax mexicanus 60.45 0.00e+00 658.00
IUUC-Bgr-012253 Blumeria graminis 32.33 6.00e-84 306.00
IUUC-Bta-013391 Bos taurus 91.28 0.00e+00 1842.00
IUUC-Bci-013956 Botrytis cinerea 34.97 4.00e-81 296.00
IUUC-Bdi-014267 Brachypodium distachyon 40.40 2.00e-116 413.00
IUUC-Bol-016075 Brassica oleracea 41.86 3.00e-121 429.00
IUUC-Bra-017057 Brassica rapa 42.30 4.00e-121 429.00
IUUC-Cja-019685 Callithrix jacchus 97.32 0.00e+00 2024.00
IUUC-Cfa-020485 Canis familiaris 93.76 0.00e+00 1844.00
IUUC-Cpo-021361 Cavia porcellus 87.64 0.00e+00 1063.00
IUUC-Cre-022824 Chlamydomonas reinhardtii 29.40 1.00e-62 235.00
IUUC-Csa-023894 Chlorocebus sabaeus 98.32 0.00e+00 1980.00
IUUC-Cho-024891 Choloepus hoffmanni 78.39 0.00e+00 751.00
IUUC-Csv-026168 Ciona savignyi 28.89 2.00e-51 197.00
IUUC-Cgl-026606 Colletotrichum gloeosporioides 33.28 5.00e-89 323.00
IUUC-Cne-026829 Cryptococcus neoformans 36.68 7.00e-93 335.00
IUUC-Cme-027110 Cyanidioschyzon merolae 34.27 5.00e-91 329.00
IUUC-Dre-027867 Danio rerio 62.87 0.00e+00 724.00
IUUC-Dno-029517 Dasypus novemcinctus 91.97 0.00e+00 1832.00
IUUC-Dor-030590 Dipodomys ordii 87.12 0.00e+00 735.00
IUUC-Dse-031471 Dothistroma septosporum 30.45 4.00e-78 286.00
IUUC-Dme-031815 Drosophila melanogaster 31.07 5.00e-54 206.00
IUUC-Ete-032421 Echinops telfairi 75.81 0.00e+00 990.00
IUUC-Eca-034058 Equus caballus 92.75 0.00e+00 1811.00
IUUC-Eeu-034597 Erinaceus europaeus 75.22 0.00e+00 1424.00
IUUC-Fca-035390 Felis catus 93.46 0.00e+00 1823.00
IUUC-Fox-038039 Fusarium oxysporum 33.83 1.00e-89 325.00
IUUC-Fso-038179 Fusarium solani 34.06 5.00e-88 319.00
IUUC-Gmo-038544 Gadus morhua 55.58 0.00e+00 662.00
IUUC-Ggr-039735 Gaeumannomyces graminis 31.84 2.00e-73 271.00
IUUC-Gga-040472 Gallus gallus 32.24 9.00e-38 152.00
IUUC-Gac-042401 Gasterosteus aculeatus 57.05 0.00e+00 700.00
IUUC-Gma-044315 Glycine max 37.55 2.00e-101 363.00
IUUC-Ggo-045628 Gorilla gorilla 98.92 0.00e+00 1969.00
IUUC-Hvu-047747 Hordeum vulgare 38.87 1.00e-109 391.00
IUUC-Itr-048493 Ictidomys tridecemlineatus 92.60 0.00e+00 1872.00
IUUC-Kpa-049087 Komagataella pastoris 34.09 7.00e-84 305.00
IUUC-Lch-050617 Latimeria chalumnae 61.27 0.00e+00 1122.00
IUUC-Lpe-051724 Leersia perrieri 42.30 4.00e-121 429.00
IUUC-Loc-052785 Lepisosteus oculatus 65.24 0.00e+00 773.00
IUUC-Lma-052956 Leptosphaeria maculans 30.63 1.00e-77 285.00
IUUC-Laf-054309 Loxodonta africana 89.10 0.00e+00 1723.00
IUUC-Mcc-055493 Macaca mulatta 97.92 0.00e+00 1961.00
IUUC-Meu-056270 Macropus eugenii 77.81 0.00e+00 922.00
IUUC-Mor-056943 Magnaporthe oryzae 35.96 2.00e-92 333.00
IUUC-Mpo-057407 Magnaporthe poae 32.67 6.00e-81 296.00
IUUC-Mtr-058172 Medicago truncatula 42.47 7.00e-116 411.00
IUUC-Mla-059170 Melampsora laricipopulina 32.64 9.00e-74 271.00
IUUC-Mga-059553 Meleagris gallopavo 31.58 2.00e-37 151.00
IUUC-Mvi-060365 Microbotryum violaceum 34.34 4.00e-84 306.00
IUUC-Mmr-061043 Microcebus murinus 91.18 0.00e+00 1756.00
IUUC-Mdo-062919 Monodelphis domestica 80.86 0.00e+00 1508.00
IUUC-Mmu-064338 Mus musculus 83.65 0.00e+00 1686.00
IUUC-Mac-065666 Musa acuminata 35.66 6.00e-90 326.00
IUUC-Mpu-066781 Mustela putorius furo 93.66 0.00e+00 1841.00
IUUC-Mlu-068076 Myotis lucifugus 91.10 0.00e+00 1814.00
IUUC-Nfi-068386 Neosartorya fischeri 35.47 3.00e-83 303.00
IUUC-Ncr-068858 Neurospora crassa 37.22 3.00e-90 327.00
IUUC-Nle-069947 Nomascus leucogenys 98.91 0.00e+00 1991.00
IUUC-Opr-070388 Ochotona princeps 85.18 0.00e+00 1154.00
IUUC-Ont-071782 Oreochromis niloticus 60.89 0.00e+00 665.00
IUUC-Oan-073331 Ornithorhynchus anatinus 80.52 0.00e+00 1383.00
IUUC-Ocu-074705 Oryctolagus cuniculus 92.17 0.00e+00 1781.00
IUUC-Oba-075881 Oryza barthii 41.71 7.00e-120 424.00
IUUC-Obr-076344 Oryza brachyantha 41.67 2.00e-115 409.00
IUUC-Ogl-076957 Oryza glaberrima 41.71 7.00e-120 424.00
IUUC-Ogu-078648 Oryza glumaepatula 41.60 8.00e-115 408.00
IUUC-Oin-079449 Oryza indica 41.71 2.00e-115 410.00
IUUC-Olo-080721 Oryza longistaminata 41.53 2.00e-115 410.00
IUUC-Ome-081579 Oryza meridionalis 41.33 1.00e-115 410.00
IUUC-Oni-083054 Oryza nivara 41.71 2.00e-115 410.00
IUUC-Opu-083706 Oryza punctata 41.80 7.00e-116 411.00
IUUC-Oru-085259 Oryza rufipogon 41.71 2.00e-115 410.00
IUUC-Osa-085568 Oryza sativa 42.03 3.00e-102 366.00
IUUC-Ola-086830 Oryzias latipes 51.50 0.00e+00 927.00
IUUC-Olu-087669 Ostreococcus lucimarinus 30.16 1.00e-59 225.00
IUUC-Oga-088120 Otolemur garnettii 87.25 0.00e+00 1647.00
IUUC-Oar-089293 Ovis aries 91.21 0.00e+00 1847.00
IUUC-Ptr-091418 Pan troglodytes 99.60 0.00e+00 2003.00
IUUC-Pan-092579 Papio anubis 98.33 0.00e+00 1511.00
IUUC-Psi-093626 Pelodiscus sinensis 71.26 0.00e+00 1231.00
IUUC-Pno-094841 Phaeosphaeria nodorum 38.27 1.00e-86 315.00
IUUC-Ppa-095291 Physcomitrella patens 46.70 9.00e-144 504.00
IUUC-Pfo-096540 Poecilia formosa 56.28 0.00e+00 684.00
IUUC-Pab-098010 Pongo abelii 99.21 0.00e+00 1993.00
IUUC-Pop-099320 Populus trichocarpa 37.86 8.00e-108 385.00
IUUC-Pca-100648 Procavia capensis 78.20 0.00e+00 1516.00
IUUC-Ppe-102077 Prunus persica 42.31 6.00e-102 365.00
IUUC-Pva-102896 Pteropus vampyrus 89.62 0.00e+00 887.00
IUUC-Pgr-103403 Puccinia graminis 31.46 7.00e-74 272.00
IUUC-Ptt-103966 Puccinia triticina 32.04 5.00e-73 270.00
IUUC-Pte-104242 Pyrenophora teres 33.00 7.00e-82 299.00
IUUC-Pyt-104728 Pyrenophora triticirepentis 33.11 1.00e-80 295.00
IUUC-Rno-106130 Rattus norvegicus 83.05 0.00e+00 1680.00
IUUC-Sce-106396 Saccharomyces cerevisiae 32.29 6.00e-74 273.00
IUUC-Sha-107221 Sarcophilus harrisii 81.94 0.00e+00 1534.00
IUUC-Sja-107985 Schizosaccharomyces japonicus 34.19 4.00e-88 320.00
IUUC-Spo-108026 Schizosaccharomyces pombe 32.07 6.00e-83 302.00
IUUC-Ssl-108388 Sclerotinia sclerotiorum 35.51 2.00e-88 320.00
IUUC-Smo-109629 Selaginella moellendorffii 44.22 2.00e-131 462.00
IUUC-Sit-109770 Setaria italica 42.04 5.00e-119 422.00
IUUC-Sly-111031 Solanum lycopersicum 37.28 3.00e-108 387.00
IUUC-Stu-112600 Solanum tuberosum 37.57 2.00e-108 387.00
IUUC-Sar-113719 Sorex araneus 91.64 0.00e+00 1714.00
IUUC-Sbi-113927 Sorghum bicolor 37.36 7.00e-104 372.00
IUUC-Sre-114938 Sporisorium reilianum 30.23 1.00e-75 278.00
IUUC-Ssc-116186 Sus scrofa 93.47 0.00e+00 1896.00
IUUC-Tru-117768 Takifugu rubripes 51.35 0.00e+00 929.00
IUUC-Tsy-118957 Tarsius syrichta 85.54 0.00e+00 1664.00
IUUC-Tni-120618 Tetraodon nigroviridis 52.24 0.00e+00 983.00
IUUC-Tca-121146 Theobroma cacao 36.42 7.00e-110 392.00
IUUC-Tre-121896 Trichoderma reesei 34.10 1.00e-94 341.00
IUUC-Tvi-122597 Trichoderma virens 34.23 2.00e-90 328.00
IUUC-Tae-123773 Triticum aestivum 41.83 5.00e-109 389.00
IUUC-Tur-125999 Triticum urartu 39.05 3.00e-109 390.00
IUUC-Tme-126953 Tuber melanosporum 33.75 4.00e-89 323.00
IUUC-Tbe-127612 Tupaia belangeri 85.10 0.00e+00 827.00
IUUC-Ttr-128243 Tursiops truncatus 88.76 0.00e+00 1370.00
IUUC-Uma-129441 Ustilago maydis 30.23 6.00e-76 279.00
IUUC-Vda-129933 Verticillium dahliae 37.02 1.00e-83 304.00
IUUC-Vpa-130672 Vicugna pacos 92.76 0.00e+00 1725.00
IUUC-Vvi-131204 Vitis vinifera 42.83 7.00e-126 445.00
IUUC-Xtr-132730 Xenopus tropicalis 61.80 0.00e+00 1251.00
IUUC-Xma-133384 Xiphophorus maculatus 52.55 0.00e+00 967.00
IUUC-Yli-134350 Yarrowia lipolytica 31.93 2.00e-74 274.00
IUUC-Zma-134966 Zea mays 42.28 1.00e-125 444.00
Created Date 25-Jun-2017

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