iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045730

UUCD1 version

UUC-HoS-00180

Ensembl Protein ID

ENSP00000379228.1

UniProt Accession

Q76N89; A7E2X0; A8MYS3; B4DH42; O15036; Q9HCC7; HECW1_HUMAN

Genbank Protein ID

BAA20780.2; BAG58003.1; AAI51228.1; BAB13352.1

Protein Name

E3 ubiquitin-protein ligase HECW1; HECT, C2 and WW domain-containing protein 1; HECT-type E3 ubiquitin transferase HECW1; NEDD4-like E3 ubiquitin-protein ligase 1

Genbank Nucleotide ID

AB002320; AK294918; AC004455; AB048365

Gene Name

HECW1; KIAA0322; NEDL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000002746.14	ENST00000395891.6	ENSP00000379228.1
ENSG00000002746.14	ENST00000453890.5	ENSP00000407774.1
ENSG00000002746.14	ENST00000429529.1	ENSP00000413336.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	19805045; 14684739

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	6.70e-122	408.7	1274	1606

Active Site

Position(s)	Description	Evidence
1574	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld+++
   Q: 1274 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFF 1362
           567899****************************************************985.6*************************** PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrl 182
           +++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY++++v++r+
   Q: 1363 TRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRV 1448
           *********************************99...9***9.********************************************** PP
   S: 183  kegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgss 272
           ++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r ++LqFvTg+s
   Q: 1449 ERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTS 1538
           ****************************************************************************************** PP
   S: 273  rlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           ++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1539 SVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
           ***************999***********************************************985 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.

Protein Sequence
(Fasta)

MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN MDLRGGPHDG 60
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIDEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGATGCAA GCGGGAGGAT AAAGCGATGA AGTGTGCTGC GTTACCGCGC ATCAGGCGCT 60
GTTGTTGGAG CCGGAACACC GTGCGACTCT GACCGAACCG GCCCCCTCCT CGCGCACACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0061630--F:ubiquitin protein ligase activity
GO:0090090--P:negative regulation of canonical Wnt signaling pathway

KEGG

hsa:23072

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	86.76	0.00e+00	2190.00
IUUC-Apl-003299	Anas platyrhynchos	80.58	0.00e+00	2442.00
IUUC-Aca-005024	Anolis carolinensis	79.39	0.00e+00	2408.00
IUUC-Bta-012604	Bos taurus	89.13	0.00e+00	2659.00
IUUC-Cja-019880	Callithrix jacchus	91.92	0.00e+00	2421.00
IUUC-Cfa-021216	Canis familiaris	91.51	0.00e+00	1815.00
IUUC-Cpo-021466	Cavia porcellus	96.99	0.00e+00	1725.00
IUUC-Csa-023080	Chlorocebus sabaeus	99.25	0.00e+00	2954.00
IUUC-Cho-024740	Choloepus hoffmanni	83.69	0.00e+00	1191.00
IUUC-Dno-030019	Dasypus novemcinctus	90.72	0.00e+00	2688.00
IUUC-Dor-031030	Dipodomys ordii	73.57	0.00e+00	1139.00
IUUC-Ete-032352	Echinops telfairi	94.29	0.00e+00	1264.00
IUUC-Eca-033948	Equus caballus	89.38	0.00e+00	2578.00
IUUC-Eeu-034474	Erinaceus europaeus	70.55	0.00e+00	838.00
IUUC-Fca-036148	Felis catus	91.97	0.00e+00	2651.00
IUUC-Fal-036957	Ficedula albicollis	81.53	0.00e+00	2445.00
IUUC-Gmo-038714	Gadus morhua	69.00	0.00e+00	1019.00
IUUC-Gga-041194	Gallus gallus	80.48	0.00e+00	2421.00
IUUC-Gac-041366	Gasterosteus aculeatus	77.78	0.00e+00	1375.00
IUUC-Ggo-045442	Gorilla gorilla	81.65	0.00e+00	2170.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	93.11	0.00e+00	2786.00
IUUC-Lch-050185	Latimeria chalumnae	69.76	0.00e+00	1962.00
IUUC-Loc-052744	Lepisosteus oculatus	75.03	0.00e+00	2232.00
IUUC-Laf-054368	Loxodonta africana	98.71	0.00e+00	1509.00
IUUC-Mcc-055487	Macaca mulatta	99.19	0.00e+00	2954.00
IUUC-Meu-056751	Macropus eugenii	91.60	0.00e+00	731.00
IUUC-Mga-059545	Meleagris gallopavo	81.10	0.00e+00	2429.00
IUUC-Mmr-061078	Microcebus murinus	91.55	0.00e+00	2600.00
IUUC-Mdo-062176	Monodelphis domestica	84.68	0.00e+00	1717.00
IUUC-Mmu-063513	Mus musculus	87.92	0.00e+00	2573.00
IUUC-Mpu-065786	Mustela putorius furo	90.43	0.00e+00	2655.00
IUUC-Mlu-067780	Myotis lucifugus	83.28	0.00e+00	2357.00
IUUC-Nle-069213	Nomascus leucogenys	99.07	0.00e+00	2864.00
IUUC-Opr-070208	Ochotona princeps	97.44	0.00e+00	1498.00
IUUC-Ont-072132	Oreochromis niloticus	81.61	0.00e+00	1368.00
IUUC-Oan-072807	Ornithorhynchus anatinus	88.11	0.00e+00	1799.00
IUUC-Ocu-074745	Oryctolagus cuniculus	89.52	0.00e+00	2592.00
IUUC-Ola-086981	Oryzias latipes	74.05	0.00e+00	1490.00
IUUC-Oga-087965	Otolemur garnettii	95.98	0.00e+00	1883.00
IUUC-Oar-089749	Ovis aries	88.19	0.00e+00	2578.00
IUUC-Ptr-091243	Pan troglodytes	99.75	0.00e+00	2962.00
IUUC-Pan-092201	Papio anubis	97.82	0.00e+00	2909.00
IUUC-Psi-093511	Pelodiscus sinensis	80.00	0.00e+00	2382.00
IUUC-Pfo-097001	Poecilia formosa	65.35	0.00e+00	1587.00
IUUC-Pab-098728	Pongo abelii	97.02	0.00e+00	2842.00
IUUC-Pca-100129	Procavia capensis	82.93	0.00e+00	1263.00
IUUC-Pva-102250	Pteropus vampyrus	79.91	0.00e+00	2186.00
IUUC-Rno-105031	Rattus norvegicus	87.77	0.00e+00	2591.00
IUUC-Tgu-117515	Taeniopygia guttata	81.68	0.00e+00	2425.00
IUUC-Tru-117914	Takifugu rubripes	75.86	0.00e+00	1382.00
IUUC-Tsy-119379	Tarsius syrichta	85.58	0.00e+00	1495.00
IUUC-Tni-120178	Tetraodon nigroviridis	70.51	0.00e+00	1441.00
IUUC-Tbe-127762	Tupaia belangeri	84.80	0.00e+00	2005.00
IUUC-Ttr-128806	Tursiops truncatus	93.14	0.00e+00	1744.00
IUUC-Xtr-132903	Xenopus tropicalis	75.76	0.00e+00	1882.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence