iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-097001

Ensembl Protein ID

ENSPFOP00000010454.2

UniProt Accession

A0A087XXF1; A0A087XXF1_POEFO

Genbank Protein ID

ENSPFOP00000010454

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AYCK01025382

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000010146.2	ENSPFOT00000010469.2	ENSPFOP00000010454.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.80e-121	405.6	981	1313

Active Site

Position(s)	Description	Evidence
1281	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+f+gEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 981  ELQRNKLYVTFLGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1066
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ + +l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLk+gG++ +Vt++Nk++Y+++
   Q: 1067 AFFTRPFYKALLRLPTDLSDLEYLDEEFHQSLQWMKDN---DITDI-LDLTFTVNEEVFGQVTERELKSGGSHLQVTEKNKKDYIER 1149
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           ++++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G+ eid++d++++t+y+ggy++ + +++wFw ++e+f++e+r +
   Q: 1150 MAKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTVEIDLSDWRSNTEYRGGYHDGHIVMRWFWAAVEKFTNEQRLR 1236
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s+++l+ekLl+A+eet+ F+l+
   Q: 1237 LLQFVTGTSSVPYEGFASLRgsngLRRFCIEKWGKVTSLPRAHTCFNRLDLPPYPSYTTLYEKLLIAVEETSTFGLE 1313
           ************************999***********************************************985 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

KQRFNFVSLP TDVLEIEVKD KFAKSRPIIK RFLGKLSVPV QRLLEKHAIG DRVVSYSLGR 60
RLPTDHVCGQ LLFRFELTSS IHPGTHHPAA GSNTVLDFIE TLTLNNTRDH SAVEQMNASV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACAGAGAT TCAACTTTGT GTCTCTGCCC ACGGATGTCC TGGAAATTGA GGTAAAGGAC 60
AAGTTTGCCA AGAGTCGGCC AATCATCAAG CGTTTTCTGG GGAAGCTTTC TGTCCCTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	77.37	0.00e+00	1289.00
IUUC-Apl-003299	Anas platyrhynchos	66.08	0.00e+00	1555.00
IUUC-Aca-005024	Anolis carolinensis	72.35	0.00e+00	1411.00
IUUC-Bta-012604	Bos taurus	78.29	0.00e+00	1332.00
IUUC-Cja-019880	Callithrix jacchus	61.05	0.00e+00	1425.00
IUUC-Cfa-021216	Canis familiaris	78.05	0.00e+00	1328.00
IUUC-Cpo-021466	Cavia porcellus	78.18	0.00e+00	1337.00
IUUC-Csa-023080	Chlorocebus sabaeus	64.96	0.00e+00	1522.00
IUUC-Cho-024740	Choloepus hoffmanni	82.45	0.00e+00	1021.00
IUUC-Dre-028750	Danio rerio	76.77	0.00e+00	1357.00
IUUC-Dno-030019	Dasypus novemcinctus	64.68	0.00e+00	1523.00
IUUC-Ete-032352	Echinops telfairi	83.24	0.00e+00	1129.00
IUUC-Eca-033948	Equus caballus	70.37	0.00e+00	1373.00
IUUC-Eeu-034474	Erinaceus europaeus	62.70	0.00e+00	730.00
IUUC-Fca-036148	Felis catus	78.21	0.00e+00	1329.00
IUUC-Fal-036957	Ficedula albicollis	64.92	0.00e+00	1540.00
IUUC-Gmo-038714	Gadus morhua	66.93	0.00e+00	1083.00
IUUC-Gga-041194	Gallus gallus	65.09	0.00e+00	1550.00
IUUC-Gac-041366	Gasterosteus aculeatus	76.72	0.00e+00	1617.00
IUUC-Ggo-045442	Gorilla gorilla	70.32	0.00e+00	1242.00
IUUC-Hsa-045730	Homo sapiens	64.82	0.00e+00	1522.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	71.33	0.00e+00	1407.00
IUUC-Lch-050185	Latimeria chalumnae	60.34	0.00e+00	1303.00
IUUC-Loc-052744	Lepisosteus oculatus	66.55	0.00e+00	1560.00
IUUC-Laf-054368	Loxodonta africana	83.57	0.00e+00	1291.00
IUUC-Mcc-055487	Macaca mulatta	71.42	0.00e+00	1392.00
IUUC-Meu-056751	Macropus eugenii	86.61	0.00e+00	696.00
IUUC-Mga-059545	Meleagris gallopavo	65.74	0.00e+00	1555.00
IUUC-Mmr-061078	Microcebus murinus	70.41	0.00e+00	1350.00
IUUC-Mdo-062176	Monodelphis domestica	70.05	0.00e+00	1341.00
IUUC-Mmu-063513	Mus musculus	70.20	0.00e+00	1380.00
IUUC-Mpu-065786	Mustela putorius furo	78.01	0.00e+00	1328.00
IUUC-Mlu-067780	Myotis lucifugus	65.73	0.00e+00	1228.00
IUUC-Nle-069213	Nomascus leucogenys	71.53	0.00e+00	1403.00
IUUC-Opr-070208	Ochotona princeps	83.08	0.00e+00	1279.00
IUUC-Ont-072132	Oreochromis niloticus	88.02	0.00e+00	1546.00
IUUC-Oan-072807	Ornithorhynchus anatinus	78.68	0.00e+00	1336.00
IUUC-Ocu-074745	Oryctolagus cuniculus	64.90	0.00e+00	1520.00
IUUC-Ola-086981	Oryzias latipes	89.01	0.00e+00	1578.00
IUUC-Oga-087965	Otolemur garnettii	70.53	0.00e+00	1353.00
IUUC-Oar-089749	Ovis aries	78.33	0.00e+00	1329.00
IUUC-Ptr-091243	Pan troglodytes	64.80	0.00e+00	1525.00
IUUC-Pan-092201	Papio anubis	64.99	0.00e+00	1523.00
IUUC-Psi-093511	Pelodiscus sinensis	77.29	0.00e+00	1316.00
IUUC-Pab-098728	Pongo abelii	63.05	0.00e+00	1434.00
IUUC-Pca-100129	Procavia capensis	67.20	0.00e+00	998.00
IUUC-Pva-102250	Pteropus vampyrus	74.45	0.00e+00	1249.00
IUUC-Rno-105031	Rattus norvegicus	64.24	0.00e+00	1493.00
IUUC-Tgu-117515	Taeniopygia guttata	65.47	0.00e+00	1542.00
IUUC-Tru-117914	Takifugu rubripes	86.60	0.00e+00	1536.00
IUUC-Tni-120178	Tetraodon nigroviridis	84.81	0.00e+00	1524.00
IUUC-Tbe-127762	Tupaia belangeri	67.88	0.00e+00	1298.00
IUUC-Ttr-128806	Tursiops truncatus	77.74	0.00e+00	1332.00
IUUC-Xtr-132903	Xenopus tropicalis	67.38	0.00e+00	1580.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence