iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000175093.4	ENST00000310546.2	ENSP00000311609.2
ENSG00000175093.4	ENST00000508126.1	ENSP00000422034.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	21199876

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.50e-17	64.2	230	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 7    lrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           l  ep +L++LCR++Ir++lg+qrl++i+ LPLP+sLk+YL+y+
   Q: 230  LDPEPLPLMDLCRRSIRSALGRQRLQDISSLPLPQSLKNYLQYQ 273
           5679**************************************97 PP

Organism

Homo sapiens

Functional Description
(View)

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MGQKLSGSLK SVEVREPALR PAKRELRGAE PGRPARLDQL LDMPAAGLAV QLRHAWNPED 60
RSLNVFVKDD DRLTFHRHPV AQSTDGIRGK VGHARGLHAW QINWPARQRG THAVVGVATA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGGCGGA GGAGGGGGAG GCGGCGGCGG CTGCAGCATC CAGAGCTGGC CGTGGCGGCC 60
GGCGCGCCCC GCGCACAAAA GCACCCAGCC CCAGGGGAGG GCGATGAACA CACCACATCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR001496--SOCS_box
IPR003877--SPRY_dom

PROSITE

PS50188--B302_SPRY
PS50225--SOCS

Pfam

PF07525--SOCS_box
PF00622--SPRY

SMART

SM00969--SOCS_box
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

hsa:92369

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001823	Ailuropoda melanoleuca	96.34	6.00e-154	536.00
IUUC-Aca-004723	Anolis carolinensis	82.05	6.00e-135	473.00
IUUC-Ame-010730	Astyanax mexicanus	77.62	3.00e-118	417.00
IUUC-Bta-012654	Bos taurus	97.44	7.00e-156	542.00
IUUC-Cel-018566	Caenorhabditis elegans	56.85	3.00e-79	288.00
IUUC-Cja-019343	Callithrix jacchus	97.44	3.00e-156	544.00
IUUC-Cfa-020061	Canis familiaris	96.70	6.00e-155	539.00
IUUC-Cpo-021975	Cavia porcellus	97.44	5.00e-155	540.00
IUUC-Csa-023630	Chlorocebus sabaeus	98.68	6.00e-132	462.00
IUUC-Cho-024458	Choloepus hoffmanni	93.79	5.00e-77	280.00
IUUC-Dre-028237	Danio rerio	77.98	2.00e-119	421.00
IUUC-Dno-028933	Dasypus novemcinctus	97.22	2.00e-123	434.00
IUUC-Ete-033077	Echinops telfairi	95.24	9.00e-152	528.00
IUUC-Eca-033453	Equus caballus	94.53	3.00e-149	520.00
IUUC-Fal-036622	Ficedula albicollis	81.68	8.00e-135	473.00
IUUC-Gmo-038808	Gadus morhua	75.18	4.00e-119	420.00
IUUC-Gga-040436	Gallus gallus	81.32	6.00e-135	473.00
IUUC-Ggo-045156	Gorilla gorilla	100.00	1.00e-159	555.00
IUUC-Itr-048821	Ictidomys tridecemlineatus	98.27	3.00e-132	464.00
IUUC-Lch-050022	Latimeria chalumnae	81.06	8.00e-124	436.00
IUUC-Loc-051943	Lepisosteus oculatus	82.05	3.00e-136	477.00
IUUC-Laf-053747	Loxodonta africana	92.31	3.00e-146	510.00
IUUC-Meu-056163	Macropus eugenii	84.98	2.00e-137	481.00
IUUC-Mmr-061796	Microcebus murinus	98.53	4.00e-157	546.00
IUUC-Mdo-062070	Monodelphis domestica	84.62	3.00e-137	480.00
IUUC-Mmu-063290	Mus musculus	97.80	3.00e-156	543.00
IUUC-Mpu-066192	Mustela putorius furo	95.97	2.00e-153	534.00
IUUC-Mlu-067789	Myotis lucifugus	94.12	1.00e-130	458.00
IUUC-Nle-069241	Nomascus leucogenys	98.90	2.00e-158	550.00
IUUC-Ont-071823	Oreochromis niloticus	76.98	2.00e-120	425.00
IUUC-Oan-072734	Ornithorhynchus anatinus	81.68	2.00e-135	475.00
IUUC-Ogl-077420	Oryza glaberrima	32.31	1.80e+00	27.70
IUUC-Ola-087207	Oryzias latipes	75.18	8.00e-117	412.00
IUUC-Oga-089170	Otolemur garnettii	87.41	1.00e-137	481.00
IUUC-Ptr-090656	Pan troglodytes	100.00	1.00e-159	555.00
IUUC-Pan-092077	Papio anubis	98.90	2.00e-158	550.00
IUUC-Psi-093552	Pelodiscus sinensis	83.15	1.00e-136	478.00
IUUC-Pma-094441	Petromyzon marinus	53.11	6.00e-81	293.00
IUUC-Pfo-096646	Poecilia formosa	77.70	3.00e-121	427.00
IUUC-Pab-098256	Pongo abelii	99.27	4.00e-159	553.00
IUUC-Pva-102621	Pteropus vampyrus	97.44	2.00e-155	541.00
IUUC-Rno-105152	Rattus norvegicus	97.80	3.00e-156	543.00
IUUC-Sha-107522	Sarcophilus harrisii	84.62	9.00e-137	479.00
IUUC-Sar-113664	Sorex araneus	95.24	1.00e-152	532.00
IUUC-Ssc-115430	Sus scrofa	97.44	6.00e-156	543.00
IUUC-Tgu-116552	Taeniopygia guttata	81.68	2.00e-134	471.00
IUUC-Tru-118631	Takifugu rubripes	74.13	1.00e-113	402.00
IUUC-Tsy-119192	Tarsius syrichta	98.70	9.00e-133	465.00
IUUC-Tni-120160	Tetraodon nigroviridis	76.64	2.00e-111	395.00
IUUC-Tae-124746	Triticum aestivum	45.45	4.50e-01	30.00
IUUC-Ttr-128238	Tursiops truncatus	97.44	3.00e-154	537.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence