iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046166

UUCD1 version

UUC-HoS-00567

Ensembl Protein ID

ENSP00000453177.1

UniProt Accession

Q86WT6; A8MX03; Q309B0; Q4G1A5; Q6W897; Q8IYY3; Q8WY16; Q8WY17; TRI69_HUMAN

Genbank Protein ID

AAL55810.1; AAL55811.1; ABB18376.1; AAQ75551.1; AAH24199.1; AAH33314.1; AAH47945.1

Protein Name

E3 ubiquitin-protein ligase TRIM69; RFP-like domain-containing protein trimless; RING finger protein 36; RING-type E3 ubiquitin transferase TRIM69; Tripartite motif-containing protein 69

Genbank Nucleotide ID

AF302088; AF302089; DQ232883; AY305385; AC122108; BC033314; BC047945

Gene Name

TRIM69; RNF36; HSD-34; HSD34

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000185880.12	ENST00000559390.5	ENSP00000453177.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circRNADb	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.00e-06	28.3	41	82

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++C + f+d pl l+CgH f++ C+   w    +++ ke  CP C+
   Q: 41   CPLCNDWFRD-PLMLSCGHNFCEACIqDFW----RLQAKETFCPECK 82
           ****999999.999************6667....88899999****6 PP

Organism

Homo sapiens

Functional Description
(View)

May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.

Protein Sequence
(Fasta)

MEVSTNPSSN IDPGDYVEMN DSITHLPSKV VIQDITMELH CPLCNDWFRD PLMLSCGHNF 60
CEACIQDFWR LQAKETFCPE CKMLCQYNNC TFNPVLDKLV EKIKKLPLLK GHPQCPEHGE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGTTTTAG CCTATCCAGT TCCGGGAGTT TGCACGCAGA CGCTCTGCTT CGTGACCTTG 60
GCTCTGCTCT GTGGGCGCCG CCCCCAGCCT GGGCGCGTCC ATCGTCGAGT ACCTTCTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0000209--P:protein polyubiquitination

KEGG

hsa:140691

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001624	Ailuropoda melanoleuca	84.37	0.00e+00	882.00
IUUC-Aca-004561	Anolis carolinensis	51.83	4.00e-141	494.00
IUUC-Bta-012390	Bos taurus	85.06	0.00e+00	844.00
IUUC-Cho-024841	Choloepus hoffmanni	87.02	0.00e+00	809.00
IUUC-Dno-029957	Dasypus novemcinctus	86.59	0.00e+00	854.00
IUUC-Eca-033954	Equus caballus	86.20	0.00e+00	915.00
IUUC-Fca-035877	Felis catus	87.40	0.00e+00	817.00
IUUC-Ggo-045395	Gorilla gorilla	98.00	0.00e+00	986.00
IUUC-Itr-048322	Ictidomys tridecemlineatus	86.40	0.00e+00	859.00
IUUC-Loc-052349	Lepisosteus oculatus	32.87	3.00e-67	249.00
IUUC-Laf-053507	Loxodonta africana	81.73	1.00e-138	486.00
IUUC-Mpu-065959	Mustela putorius furo	66.80	3.00e-180	624.00
IUUC-Mlu-067236	Myotis lucifugus	71.07	4.00e-135	474.00
IUUC-Nle-069116	Nomascus leucogenys	95.60	0.00e+00	993.00
IUUC-Opr-070560	Ochotona princeps	86.93	8.00e-71	260.00
IUUC-Ocu-074335	Oryctolagus cuniculus	87.62	0.00e+00	850.00
IUUC-Oga-088034	Otolemur garnettii	85.57	0.00e+00	877.00
IUUC-Oar-090179	Ovis aries	84.60	0.00e+00	816.00
IUUC-Ptr-090633	Pan troglodytes	98.20	0.00e+00	986.00
IUUC-Pva-102774	Pteropus vampyrus	85.25	0.00e+00	810.00
IUUC-Rno-105356	Rattus norvegicus	79.80	0.00e+00	862.00
IUUC-Ssc-115359	Sus scrofa	86.57	0.00e+00	847.00
IUUC-Tsy-119536	Tarsius syrichta	83.23	0.00e+00	823.00
IUUC-Ttr-128823	Tursiops truncatus	85.31	0.00e+00	848.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence