iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065708

Ensembl Protein ID

ENSMPUP00000006919.1

UniProt Accession

G9KLD4; G9KLD4_MUSPF

Genbank Protein ID

AES05713.1

Protein Name

Ring finger protein 125

Genbank Nucleotide ID

AEYP01012106

Gene Name

RNF125

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000006975.1	ENSMPUT00000007034.1	ENSMPUP00000006919.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.50e-10	41.0	33	98
E3 activity/RING/RING	1.30e-08	35.2	37	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqawc 69
             f C++ le+ ++Pv + +G+++ rs+I+  l++++ tcP +r+ l +e +    + +r+ +++ 
   Q: 33   TSFDCSVCLEVLHQPVRTRCGHVFCRSCIATSLKNNKWTCPYCRAYLPSEGVPATDVAKRMKSEYQ 98
           579******************************99999*********9999999999999999885 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cle + + p+ ++CgHvf+++C+   +      ++++++CP+Cr
   Q: 37   CSVCLEVLHQ-PVRTRCGHVFCRSCIaTSL------KNNKWTCPYCR 76
           ********99.777***********95555......**********8 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MGSVLSSDSG KSAPASAAPR ALERKGDPEL PVTSFDCSVC LEVLHQPVRT RCGHVFCRSC 60
IATSLKNNKW TCPYCRAYLP SEGVPATDVA KRMKSEYQKC TECDTPVCLS EMRAHIRSCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTTTTCC CCAAAATTTT ATTTATTTAT TTATTTATTT ATTTATGTAT TTGAGAGAGA 60
GTGAGAGCAG AGGGGGAGAA GTAGAGGGAG GGGGCAAAAG AGGGAGAAGT GGACTCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51803--ZF_C2HC_RNF
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19

SMART

SM00184--RING

Gene Ontology

GO:0000139--C:Golgi membrane
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0039536--P:negative regulation of RIG-I signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001992	Ailuropoda melanoleuca	96.12	5.00e-126	442.00
IUUC-Aca-004839	Anolis carolinensis	63.13	2.00e-66	244.00
IUUC-Bta-012827	Bos taurus	89.66	2.00e-118	417.00
IUUC-Cja-018794	Callithrix jacchus	89.66	4.00e-118	416.00
IUUC-Cfa-021234	Canis familiaris	94.83	9.00e-121	425.00
IUUC-Cpo-022412	Cavia porcellus	80.60	3.00e-105	374.00
IUUC-Csa-023406	Chlorocebus sabaeus	90.09	2.00e-119	421.00
IUUC-Cho-024427	Choloepus hoffmanni	76.27	2.00e-75	274.00
IUUC-Dno-030085	Dasypus novemcinctus	90.95	6.00e-121	426.00
IUUC-Dor-030911	Dipodomys ordii	68.97	2.00e-70	258.00
IUUC-Ete-032469	Echinops telfairi	85.34	8.00e-114	402.00
IUUC-Eca-034352	Equus caballus	92.67	3.00e-122	430.00
IUUC-Eeu-034889	Erinaceus europaeus	75.86	3.00e-93	334.00
IUUC-Fca-036116	Felis catus	94.83	3.00e-120	423.00
IUUC-Hsa-046518	Homo sapiens	90.09	2.00e-119	421.00
IUUC-Itr-048344	Ictidomys tridecemlineatus	93.79	5.00e-98	349.00
IUUC-Laf-053363	Loxodonta africana	90.60	8.00e-120	422.00
IUUC-Meu-056101	Macropus eugenii	76.78	2.00e-94	337.00
IUUC-Mdo-062046	Monodelphis domestica	74.25	8.00e-98	349.00
IUUC-Mmu-063184	Mus musculus	82.14	3.00e-56	209.00
IUUC-Mlu-067561	Myotis lucifugus	84.18	3.00e-89	320.00
IUUC-Nle-069665	Nomascus leucogenys	88.79	5.00e-107	379.00
IUUC-Opr-070301	Ochotona princeps	79.74	8.00e-100	355.00
IUUC-Ocu-074562	Oryctolagus cuniculus	90.48	5.00e-65	239.00
IUUC-Oga-088958	Otolemur garnettii	91.81	4.00e-121	426.00
IUUC-Oar-089541	Ovis aries	89.27	5.00e-94	336.00
IUUC-Ptr-090989	Pan troglodytes	90.09	8.00e-120	422.00
IUUC-Pan-092372	Papio anubis	89.22	1.00e-118	418.00
IUUC-Pab-098718	Pongo abelii	77.59	2.00e-94	337.00
IUUC-Pca-100453	Procavia capensis	88.79	5.00e-118	416.00
IUUC-Pva-102931	Pteropus vampyrus	94.40	2.00e-118	417.00
IUUC-Rno-105771	Rattus norvegicus	86.79	6.00e-99	353.00
IUUC-Sha-107557	Sarcophilus harrisii	73.39	1.00e-100	358.00
IUUC-Sar-113435	Sorex araneus	91.27	7.00e-67	244.00
IUUC-Ssc-116388	Sus scrofa	92.24	3.00e-122	430.00
IUUC-Tsy-119439	Tarsius syrichta	90.96	8.00e-96	342.00
IUUC-Tre-121992	Trichoderma reesei	29.90	2.00e-07	50.40
IUUC-Tbe-127417	Tupaia belangeri	64.71	1.00e-69	255.00
IUUC-Ttr-129212	Tursiops truncatus	93.10	2.00e-123	434.00
IUUC-Vpa-130153	Vicugna pacos	91.81	5.00e-122	429.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence