iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073019

UUCD1 version

UUC-OrA-00232

Ensembl Protein ID

ENSOANP00000013575.2

UniProt Accession

F6VTL6; F6VTL6_ORNAN

Protein Name

Uncharacterized protein

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000008529.2	ENSOANT00000013578.2	ENSOANP00000013575.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-135	451.8	522	851

Active Site

Position(s)	Description	Evidence
821	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld ++
   Q: 522  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 610
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl++i en   d +e  ldl+f+v+ee++g+t+++eLk +G++i Vtn+Nk+eY++lv+++r
   Q: 611  IRPFYKMMLHKPITLHDMESVDSEYYNSLQWIIEN---DPTE--LDLRFTVDEELFGQTHQHELKADGSEIVVTNKNKKEYIHLVIQWR 694
           *********************************99...6666..7999999************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + +++++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy+ ++++iqwFw+++ +++se+r ++LqFvTg
   Q: 695  FVNRVQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYNVNHQVIQWFWKAVLMMDSEKRIRLLQFVTG 783
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p++f++++++s+d+lP+++TCfn+L+LP+Y+s e l +kL +Aie+t+gF+
   Q: 784  TSRVPMNGFAELYgsngPQFFTVEQWGSPDKLPRAHTCFNRLDLPPYESFEDLWDKLHVAIENTQGFD 851
           *******************************************************************8 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MYDPVRGCLT SIQTKTVKKT LNPKWNEEIF FRVHPQQHRL LFEVFDENRL TRDDFLGQVD 60
VPLYQLPTEN PNLERPYTFK DFVLHPRSHK SRVKGYLRLK MTYLPKTNGS EEENTEQAEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGACAAATA GAAAATTAAA ACTTATTCCC TTTTTATTTT AGGAAAATTC AAGAATTGTG 60
CGGGTGAAGG TTATAGCCGG AATTGGCCTA GCTAAAAAAG ATCTCTTAGG AGCTTGGTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0016020--C:membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0003197--P:endocardial cushion development
GO:0010766--P:negative regulation of sodium ion transport
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0003151--P:outflow tract morphogenesis
GO:0045732--P:positive regulation of protein catabolic process
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0048814--P:regulation of dendrite morphogenesis
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	86.09	0.00e+00	1391.00
IUUC-Apl-003886	Anas platyrhynchos	77.91	0.00e+00	1359.00
IUUC-Acl-008273	Aspergillus clavatus	47.79	3.00e-153	535.00
IUUC-Afl-008713	Aspergillus flavus	47.11	3.00e-153	535.00
IUUC-Afu-009103	Aspergillus fumigatus	47.62	1.00e-154	539.00
IUUC-Ani-009259	Aspergillus nidulans	47.27	2.00e-154	539.00
IUUC-Ang-009738	Aspergillus niger	46.79	3.00e-153	535.00
IUUC-Aor-010053	Aspergillus oryzae	56.04	1.00e-97	348.00
IUUC-Ate-010529	Aspergillus terreus	47.02	2.00e-153	535.00
IUUC-Ame-011138	Astyanax mexicanus	84.97	0.00e+00	851.00
IUUC-Bgr-012148	Blumeria graminis	45.72	2.00e-149	522.00
IUUC-Bta-012453	Bos taurus	83.33	0.00e+00	1319.00
IUUC-Bci-013785	Botrytis cinerea	46.39	2.00e-153	535.00
IUUC-Cel-018564	Caenorhabditis elegans	52.45	1.00e-176	612.00
IUUC-Cja-019034	Callithrix jacchus	85.03	0.00e+00	1296.00
IUUC-Cfa-020258	Canis familiaris	85.84	0.00e+00	1368.00
IUUC-Cpo-021648	Cavia porcellus	83.04	0.00e+00	1425.00
IUUC-Csa-023334	Chlorocebus sabaeus	86.43	0.00e+00	1452.00
IUUC-Cin-025157	Ciona intestinalis	55.20	0.00e+00	909.00
IUUC-Csv-026098	Ciona savignyi	67.71	0.00e+00	630.00
IUUC-Dno-029159	Dasypus novemcinctus	83.79	0.00e+00	1219.00
IUUC-Dse-031241	Dothistroma septosporum	46.95	2.00e-152	532.00
IUUC-Dme-032166	Drosophila melanogaster	68.13	0.00e+00	707.00
IUUC-Ete-032409	Echinops telfairi	79.54	0.00e+00	1112.00
IUUC-Eca-033441	Equus caballus	85.96	0.00e+00	1421.00
IUUC-Eeu-034546	Erinaceus europaeus	73.30	0.00e+00	1103.00
IUUC-Fca-036384	Felis catus	85.50	0.00e+00	1390.00
IUUC-Fal-037547	Ficedula albicollis	83.86	0.00e+00	1393.00
IUUC-Fox-037774	Fusarium oxysporum	46.83	7.00e-154	537.00
IUUC-Gmo-039679	Gadus morhua	68.34	0.00e+00	1152.00
IUUC-Gga-040524	Gallus gallus	84.21	0.00e+00	1392.00
IUUC-Gac-042607	Gasterosteus aculeatus	68.61	0.00e+00	1174.00
IUUC-Hsa-046479	Homo sapiens	86.34	0.00e+00	1392.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	75.73	0.00e+00	1101.00
IUUC-Lch-050445	Latimeria chalumnae	74.54	0.00e+00	1204.00
IUUC-Loc-052645	Lepisosteus oculatus	76.25	0.00e+00	1291.00
IUUC-Laf-053638	Loxodonta africana	78.04	0.00e+00	1256.00
IUUC-Mcc-055585	Macaca mulatta	86.71	0.00e+00	1382.00
IUUC-Meu-056897	Macropus eugenii	95.12	3.00e-170	591.00
IUUC-Mla-058996	Melampsora laricipopulina	53.43	4.00e-147	514.00
IUUC-Mga-059362	Meleagris gallopavo	77.84	0.00e+00	1362.00
IUUC-Mvi-060395	Microbotryum violaceum	53.31	5.00e-147	514.00
IUUC-Mmr-061061	Microcebus murinus	86.21	0.00e+00	1395.00
IUUC-Mmu-063318	Mus musculus	74.71	0.00e+00	1246.00
IUUC-Mpu-066567	Mustela putorius furo	85.30	0.00e+00	1475.00
IUUC-Mlu-068148	Myotis lucifugus	86.09	0.00e+00	1384.00
IUUC-Nfi-068427	Neosartorya fischeri	47.62	1.00e-154	539.00
IUUC-Ncr-068918	Neurospora crassa	47.66	6.00e-154	537.00
IUUC-Nle-069225	Nomascus leucogenys	86.21	0.00e+00	1406.00
IUUC-Ont-071664	Oreochromis niloticus	68.54	0.00e+00	1157.00
IUUC-Ocu-074409	Oryctolagus cuniculus	85.34	0.00e+00	1381.00
IUUC-Oga-088241	Otolemur garnettii	79.93	0.00e+00	1248.00
IUUC-Oar-089797	Ovis aries	85.08	0.00e+00	1434.00
IUUC-Ptr-091629	Pan troglodytes	85.85	0.00e+00	1267.00
IUUC-Psi-093618	Pelodiscus sinensis	85.22	0.00e+00	1317.00
IUUC-Pma-094364	Petromyzon marinus	81.29	0.00e+00	815.00
IUUC-Pno-095118	Phaeosphaeria nodorum	47.68	7.00e-158	550.00
IUUC-Pfo-097145	Poecilia formosa	68.87	0.00e+00	1146.00
IUUC-Pab-098394	Pongo abelii	85.96	0.00e+00	1451.00
IUUC-Pca-100568	Procavia capensis	72.71	0.00e+00	1055.00
IUUC-Pgr-103620	Puccinia graminis	52.60	2.00e-144	505.00
IUUC-Ptt-103806	Puccinia triticina	51.82	1.00e-118	420.00
IUUC-Pte-104016	Pyrenophora teres	47.77	2.00e-157	548.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	47.77	2.00e-157	548.00
IUUC-Rno-106095	Rattus norvegicus	75.29	0.00e+00	1263.00
IUUC-Sce-106289	Saccharomyces cerevisiae	48.02	4.00e-157	548.00
IUUC-Sha-107370	Sarcophilus harrisii	80.97	0.00e+00	1319.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.76	2.00e-150	525.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	46.64	1.00e-153	536.00
IUUC-Sre-114929	Sporisorium reilianum	47.52	1.00e-152	533.00
IUUC-Tgu-117474	Taeniopygia guttata	84.68	0.00e+00	1412.00
IUUC-Tru-117675	Takifugu rubripes	66.67	0.00e+00	1142.00
IUUC-Tni-119993	Tetraodon nigroviridis	66.74	0.00e+00	1135.00
IUUC-Tvi-122595	Trichoderma virens	45.79	8.00e-151	526.00
IUUC-Tbe-127408	Tupaia belangeri	78.92	0.00e+00	1055.00
IUUC-Ttr-128437	Tursiops truncatus	76.89	0.00e+00	1068.00
IUUC-Uma-129332	Ustilago maydis	52.80	2.00e-141	495.00
IUUC-Vda-129753	Verticillium dahliae	45.73	9.00e-151	526.00
IUUC-Vpa-130503	Vicugna pacos	78.98	0.00e+00	1184.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence