• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
UUCD2 ID IUUC-Bta-012929
UUCD1 version UUC-BoT-01105
Ensembl Protein ID ENSBTAP00000015787.5
UniProt Accession A6QR55; UBP4_BOVIN
Genbank Protein ID AAI50121.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 4; Deubiquitinating enzyme 4; Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4
Genbank Nucleotide ID BC150120
Gene Name USP4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000011899.5 ENSBTAT00000015787.5 ENSBTAP00000015787.5
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.80e-114 381.9 302 923
ULD/UDP/UBQ/UBQ_Other 3.10e-18 65.6 143 221
Active Site
Position(s) Description Evidence
311 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
881 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl NlgNtC+mNS+LQcLsn+ +l++++l+ +++ ++n++np ++kge+++++++l++++w++++ +v+pr+++++++++a++fsgy+
   Q: 302  CGLGNLGNTCFMNSALQCLSNTAPLTDYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQ 390
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ k+kp+ e+++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l
   Q: 391  QQDSQELLAFLLDGLHEDLNRVKKKPYLELKDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 477
           ******************************8888..5555556777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 478  TLPLPLKKDRVMEiflvpadprcrptqyrvvvplmgavsdlcealsklsgiaaenmvvtdvynhrfhkifqmdeglnhimprddifvye 566
           ********99999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 567  vcstspdgsecvtlpvyfrerksrpsststgavlygqpllvsvpkhkltleslyqavcerisryikqplpdesgssplelgacngsrsg 655
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 656  cagedeeemehqeegreqlsetegsgddepgsdhgeatqkknkgrpcprrlftfslvnsygtadinslatdgkllklnsrstlaidwds 744
           ***************************************************************************************** PP
   S: 186  ................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfsee 242
                                            l+dc+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++
   Q: 745  etrscyyneqesetyekhvsmlqpqkkkktavALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY 833
           ************************************************************************************99885 PP
   S: 243  qksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkne.kgkWllfdDskVtevkeeevleetgst 329
              r k+++ vefp + L++s+f+++p+     ++ Y+Liav +H+G ++ GHY+ay+kn+ +gkW++fdDs+V+   e+++++   + 
   Q: 834  --WRDKLDTVVEFPVRgLNMSEFVCDPSAR---PYVYDLIAVSNHYGAMGVGHYTAYAKNKlNGKWYYFDDSNVSLACEDQIVT---KA 914
           ..567*********************8866...9**************************52666*******************...** PP
   S: 330  aYvlfYkrr 338
           aYvlfY+rr
   Q: 915  AYVLFYQRR 923
           *******96 PP
   

   ULD/UDP/UBQ/UBQ_Other
   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d + +l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 143  CENSDPTnVLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTVQDAGLYQGQVLVIEPQNED 221
           78999999**************************888*****9999977444.46********************99986 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.
 Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.
Protein Sequence
(Fasta)
MAEGGGYRER PDAETQKSEL GALMRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYNVG 60
EHNLYPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPAEA WNKLLNWYGC VEGQQPIVRK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012929|DUB,USP;ULD,UBQ_Other|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGACGAGATG GCGGAAGGCG GAGGGTACCG TGAGCGACCG GATGCGGAGA CCCAGAAATC 60
CGAGCTCGGG GCCTTGATGA GGACCACTCT CCAGCGAGGG GCGCAGTGGT GAGCGCCGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012929|DUB,USP;ULD,UBQ_Other|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH
SMART

SM00695--DUSP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG bta:508042
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001597 Ailuropoda melanoleuca 94.19 0.00e+00 1698.00
IUUC-Atr-002991 Amborella trichopoda 35.40 2.00e-143 503.00
IUUC-Apl-004068 Anas platyrhynchos 70.64 0.00e+00 1216.00
IUUC-Aca-004459 Anolis carolinensis 69.65 0.00e+00 1252.00
IUUC-Ago-007911 Ashbya gossypii 38.26 2.00e-63 238.00
IUUC-Ang-009562 Aspergillus niger 45.52 1.00e-55 212.00
IUUC-Ame-011064 Astyanax mexicanus 64.18 0.00e+00 898.00
IUUC-Bdi-014013 Brachypodium distachyon 36.55 8.00e-152 531.00
IUUC-Cja-018798 Callithrix jacchus 92.52 0.00e+00 1674.00
IUUC-Cfa-020599 Canis familiaris 95.12 0.00e+00 1738.00
IUUC-Cpo-022144 Cavia porcellus 89.57 0.00e+00 1634.00
IUUC-Csa-023770 Chlorocebus sabaeus 93.72 0.00e+00 1595.00
IUUC-Cho-024595 Choloepus hoffmanni 84.56 0.00e+00 1110.00
IUUC-Cne-026852 Cryptococcus neoformans 40.50 9.00e-73 269.00
IUUC-Dre-027869 Danio rerio 63.55 0.00e+00 1222.00
IUUC-Dno-029316 Dasypus novemcinctus 91.60 0.00e+00 1718.00
IUUC-Ete-032970 Echinops telfairi 82.22 0.00e+00 1070.00
IUUC-Eca-034012 Equus caballus 94.40 0.00e+00 1715.00
IUUC-Eeu-035158 Erinaceus europaeus 79.02 0.00e+00 810.00
IUUC-Fca-035373 Felis catus 90.46 0.00e+00 1683.00
IUUC-Fal-037634 Ficedula albicollis 74.57 0.00e+00 1310.00
IUUC-Fox-037986 Fusarium oxysporum 41.67 5.00e-64 240.00
IUUC-Gmo-038866 Gadus morhua 68.54 0.00e+00 861.00
IUUC-Ggr-039740 Gaeumannomyces graminis 42.86 4.00e-62 234.00
IUUC-Gga-040729 Gallus gallus 69.76 0.00e+00 1272.00
IUUC-Gac-042631 Gasterosteus aculeatus 67.68 0.00e+00 1263.00
IUUC-Ggo-045337 Gorilla gorilla 92.40 0.00e+00 1531.00
IUUC-Hsa-045669 Homo sapiens 94.08 0.00e+00 1714.00
IUUC-Itr-048610 Ictidomys tridecemlineatus 93.26 0.00e+00 1727.00
IUUC-Lch-050533 Latimeria chalumnae 68.20 0.00e+00 1195.00
IUUC-Lpe-051424 Leersia perrieri 36.68 2.00e-149 523.00
IUUC-Loc-051800 Lepisosteus oculatus 65.98 0.00e+00 1319.00
IUUC-Laf-053803 Loxodonta africana 93.15 0.00e+00 1735.00
IUUC-Mcc-055556 Macaca mulatta 90.13 0.00e+00 1608.00
IUUC-Meu-056742 Macropus eugenii 71.77 0.00e+00 1339.00
IUUC-Mor-056985 Magnaporthe oryzae 42.50 7.00e-62 233.00
IUUC-Mpo-057486 Magnaporthe poae 43.57 3.00e-62 234.00
IUUC-Mtr-058563 Medicago truncatula 34.05 2.00e-133 469.00
IUUC-Mga-059300 Meleagris gallopavo 70.35 0.00e+00 1238.00
IUUC-Mdo-061848 Monodelphis domestica 83.88 0.00e+00 1571.00
IUUC-Mmu-063960 Mus musculus 90.24 0.00e+00 1671.00
IUUC-Mpu-066920 Mustela putorius furo 94.81 0.00e+00 1734.00
IUUC-Mlu-068088 Myotis lucifugus 93.15 0.00e+00 1724.00
IUUC-Ncr-068879 Neurospora crassa 45.23 3.00e-61 231.00
IUUC-Nle-070010 Nomascus leucogenys 94.18 0.00e+00 1715.00
IUUC-Opr-070740 Ochotona princeps 90.15 0.00e+00 1223.00
IUUC-Ont-072573 Oreochromis niloticus 66.10 0.00e+00 1288.00
IUUC-Oan-073363 Ornithorhynchus anatinus 76.50 0.00e+00 1424.00
IUUC-Ocu-074242 Oryctolagus cuniculus 88.45 0.00e+00 1614.00
IUUC-Oba-075553 Oryza barthii 42.32 1.00e-129 457.00
IUUC-Obr-076902 Oryza brachyantha 37.02 3.00e-148 519.00
IUUC-Ogl-077583 Oryza glaberrima 42.32 1.00e-129 457.00
IUUC-Ogu-077990 Oryza glumaepatula 41.82 9.00e-124 438.00
IUUC-Oin-079300 Oryza indica 42.48 1.00e-130 461.00
IUUC-Olo-080315 Oryza longistaminata 36.19 6.00e-146 511.00
IUUC-Ome-081271 Oryza meridionalis 35.84 2.00e-147 516.00
IUUC-Oni-082303 Oryza nivara 41.67 1.00e-124 441.00
IUUC-Opu-083770 Oryza punctata 41.77 1.00e-127 450.00
IUUC-Oru-085141 Oryza rufipogon 42.09 1.00e-126 447.00
IUUC-Osa-085641 Oryza sativa 42.48 1.00e-130 461.00
IUUC-Ola-086553 Oryzias latipes 66.97 0.00e+00 1290.00
IUUC-Olu-087717 Ostreococcus lucimarinus 40.34 1.00e-124 440.00
IUUC-Oga-088562 Otolemur garnettii 86.00 0.00e+00 1497.00
IUUC-Oar-090439 Ovis aries 99.27 0.00e+00 1827.00
IUUC-Ptr-090801 Pan troglodytes 94.08 0.00e+00 1711.00
IUUC-Pan-092717 Papio anubis 89.11 0.00e+00 1576.00
IUUC-Psi-093942 Pelodiscus sinensis 74.44 0.00e+00 1314.00
IUUC-Pfo-097060 Poecilia formosa 65.60 0.00e+00 1274.00
IUUC-Pab-098522 Pongo abelii 92.90 0.00e+00 1241.00
IUUC-Pca-100161 Procavia capensis 83.09 0.00e+00 1496.00
IUUC-Rno-106081 Rattus norvegicus 89.42 0.00e+00 1677.00
IUUC-Sha-106937 Sarcophilus harrisii 82.27 0.00e+00 1541.00
IUUC-Sit-109948 Setaria italica 36.45 3.00e-141 496.00
IUUC-Sly-111746 Solanum lycopersicum 37.39 1.00e-150 527.00
IUUC-Stu-112671 Solanum tuberosum 37.58 1.00e-148 520.00
IUUC-Sar-113542 Sorex araneus 87.45 0.00e+00 1623.00
IUUC-Sbi-114874 Sorghum bicolor 36.44 1.00e-143 504.00
IUUC-Sre-115130 Sporisorium reilianum 38.50 3.00e-77 284.00
IUUC-Ssc-115637 Sus scrofa 95.74 0.00e+00 1743.00
IUUC-Tgu-117267 Taeniopygia guttata 71.11 0.00e+00 1302.00
IUUC-Tru-118634 Takifugu rubripes 66.98 0.00e+00 1220.00
IUUC-Tca-121001 Theobroma cacao 36.35 7.00e-156 544.00
IUUC-Tae-125295 Triticum aestivum 35.25 2.00e-148 520.00
IUUC-Tbe-127669 Tupaia belangeri 76.20 0.00e+00 925.00
IUUC-Ttr-128778 Tursiops truncatus 95.12 0.00e+00 1747.00
IUUC-Uma-129498 Ustilago maydis 43.06 1.00e-72 268.00
IUUC-Vda-129781 Verticillium dahliae 29.65 2.00e-68 254.00
IUUC-Vpa-130571 Vicugna pacos 97.58 0.00e+00 1156.00
IUUC-Vvi-131010 Vitis vinifera 38.51 5.00e-152 531.00
IUUC-Xtr-132305 Xenopus tropicalis 69.11 0.00e+00 1287.00
IUUC-Xma-133176 Xiphophorus maculatus 71.08 0.00e+00 841.00
IUUC-Yli-134392 Yarrowia lipolytica 43.17 8.00e-62 233.00
IUUC-Zma-135699 Zea mays 36.07 7.00e-144 504.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved