iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118634

UUCD1 version

UUC-TaR-01122

Ensembl Protein ID

ENSTRUP00000012091.1

UniProt Accession

H2SI59; H2SI59_TAKRU

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000005043.1	ENSTRUT00000012149.1	ENSTRUP00000012089.1
ENSTRUG00000005043.1	ENSTRUT00000012150.1	ENSTRUP00000012090.1
ENSTRUG00000005043.1	ENSTRUT00000012151.1	ENSTRUP00000012091.1
ENSTRUG00000005043.1	ENSTRUT00000012152.1	ENSTRUP00000012092.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.70e-115	385.6	319	936
ULD/UDP/UBQ/UBQ_Other	2.50e-09	38.1	169	237

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl+NlgNtC+mNS+LQcLsn ++l+e++l+ +++ ++n+enp ++ ge+++++++l++++w s++++v+pr+++++++++a++fsgy+
   Q: 319  CGLSNLGNTCFMNSALQCLSNASPLTEYFLNdQYEAEINRENPLGMRGEIAEAYADLVKQMWLSRSSYVAPRSFKTQVGRFAPQFSGYQ 407
           7******************************99******************************************************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ k+kp+  +++++   ++de     a+ ++  +n+s+i+d+F+g +ks+++c+ec +vs++++pf++l
   Q: 408  QQDSQELLAFLLDGLHEDLNRVKKKPYLALRDAE--GRPDEivakeAWTNHRLRNDSIIVDIFHGLFKSTLVCPECSKVSVTFDPFCYL 494
           ***************************9998887..6666667777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p+k+++ +e                                                                            
   Q: 495  TLPLPMKKDRTLEvflvrsdpqsrptqyrvvvpklgtvtdlccaltklcgvapenmmvadvynhrfhkiyrrddglnqimekddifvye 583
           ********99988**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 584  vqeedgermnlpvyfrerhskhigsststvlfgqpllitvpkhnliadvlydkilerigryvkhtqspnsdsrasasasfasssqaaec 672
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 673  stsceeeamdhqvspepenghseeeeasdlengskadaikpcsppaklftfsvvnsygtanisslpcdgnvlqlnphstvaidwdtesk 761
           ***************************************************************************************** PP
   S: 186  ............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksr 246
                                        l++c+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs+++  + r
   Q: 762  klhydeqeaeayekhesmlqpqkkkatvALKECIELFTTMETLGEHDPWYCPTCKKHQQATKKFDLWSLPRILVVHLKRFSYNR--CWR 848
           ********************************************************************************9966..677 PP
   S: 247  ekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvl 333
            k+++ v+fp++ L++s+f+++p+ +   +++Y+Liav +H+G++++GHY+ay kn+ ++ W++fdDs+V++ +e+++++   + aYvl
   Q: 849  DKLDTVVDFPIRdLNMSEFVCDPKAS---PYIYDLIAVSNHYGGMGGGHYTAYGKNKADGkWYYFDDSSVSSASEDQIVT---KAAYVL 931
           8*********************9976...9**************************65445*******************...****** PP
   S: 334  fYkrr 338
           fY+rr
   Q: 932  FYQRR 936
           ***96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 14   tlkvnpsdtVaeLKekiekklgip.peqqrLiyk.....GkiL.eddktLadyglkdgstihllekksg 75
           t+ ++++dt+ ++ ++++++++ip + + rL++k      + L ++d t++d gl++g+++++++k+++
   Q: 169  TRYFSKADTIDTIEKEMRTLFKIPaEKETRLWNKymsntYEQLnKPDSTVQDAGLFHGQVLVIEQKNED 237
           4448999*****************777*****999987744457*********************9986 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MAEGGGPESA GAADSDSEPV AGQMPTPSTE SQKQTIGSLL KTALRKGDEW YLIDSRWFKQ 60
WKKYVGFDSW DMYNVGERNL YPGPIDNSGL FSDQDTQALK EHLIDELDYV LVPTEAWNKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCATGATGG CCGAGGGAGG CGGACCCGAG TCGGCTGGCG CGGCAGACTC CGACTCGGAG 60
CCGGTTGCTG GTCAAATGCC AACACCTTCA ACCGAAAGCC AAAAACAGAC AATCGGGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0034122--P:negative regulation of toll-like receptor signaling pathway
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	68.53	0.00e+00	1222.00
IUUC-Atr-002991	Amborella trichopoda	36.24	9.00e-142	497.00
IUUC-Apl-004068	Anas platyrhynchos	62.22	0.00e+00	1065.00
IUUC-Aca-004459	Anolis carolinensis	63.66	0.00e+00	1147.00
IUUC-Aly-006315	Arabidopsis lyrata	41.61	2.00e-123	436.00
IUUC-Ath-007343	Arabidopsis thaliana	37.76	5.00e-153	535.00
IUUC-Acl-008284	Aspergillus clavatus	36.98	4.00e-55	210.00
IUUC-Afu-008878	Aspergillus fumigatus	34.69	2.00e-57	218.00
IUUC-Ang-009562	Aspergillus niger	45.39	2.00e-56	215.00
IUUC-Ate-010323	Aspergillus terreus	39.02	4.00e-58	220.00
IUUC-Ame-011064	Astyanax mexicanus	76.50	0.00e+00	1064.00
IUUC-Bta-012929	Bos taurus	67.25	0.00e+00	1239.00
IUUC-Bra-017029	Brassica rapa	35.93	9.00e-138	484.00
IUUC-Cfa-020599	Canis familiaris	67.51	0.00e+00	1233.00
IUUC-Cpo-022144	Cavia porcellus	67.50	0.00e+00	1196.00
IUUC-Cho-024595	Choloepus hoffmanni	62.42	0.00e+00	771.00
IUUC-Csv-026109	Ciona savignyi	46.07	9.00e-149	521.00
IUUC-Cme-027338	Cyanidioschyzon merolae	57.95	4.00e-66	246.00
IUUC-Dre-027869	Danio rerio	83.38	0.00e+00	1076.00
IUUC-Dno-029316	Dasypus novemcinctus	67.82	0.00e+00	1236.00
IUUC-Ete-032970	Echinops telfairi	63.08	0.00e+00	764.00
IUUC-Fal-037634	Ficedula albicollis	65.10	0.00e+00	1157.00
IUUC-Gmo-038866	Gadus morhua	79.15	0.00e+00	1408.00
IUUC-Gga-040729	Gallus gallus	61.29	0.00e+00	1114.00
IUUC-Gac-042631	Gasterosteus aculeatus	87.63	0.00e+00	1590.00
IUUC-Ggo-045337	Gorilla gorilla	66.40	0.00e+00	1095.00
IUUC-Hsa-045669	Homo sapiens	67.47	0.00e+00	1221.00
IUUC-Hvu-047108	Hordeum vulgare	39.94	9.00e-120	424.00
IUUC-Mcc-055556	Macaca mulatta	65.37	0.00e+00	1158.00
IUUC-Meu-056742	Macropus eugenii	64.55	0.00e+00	822.00
IUUC-Mla-058848	Melampsora laricipopulina	32.28	1.00e-73	272.00
IUUC-Mga-059300	Meleagris gallopavo	62.73	0.00e+00	1080.00
IUUC-Mmu-063960	Mus musculus	67.35	0.00e+00	1206.00
IUUC-Mpu-066920	Mustela putorius furo	67.89	0.00e+00	1236.00
IUUC-Mlu-068088	Myotis lucifugus	67.25	0.00e+00	1226.00
IUUC-Nle-070010	Nomascus leucogenys	67.71	0.00e+00	1219.00
IUUC-Ont-072573	Oreochromis niloticus	85.50	0.00e+00	1651.00
IUUC-Oan-073363	Ornithorhynchus anatinus	69.21	0.00e+00	861.00
IUUC-Ogu-077990	Oryza glumaepatula	41.60	9.00e-123	434.00
IUUC-Oin-079300	Oryza indica	42.15	2.00e-128	453.00
IUUC-Oni-082303	Oryza nivara	41.20	4.00e-122	432.00
IUUC-Opu-083770	Oryza punctata	41.78	5.00e-127	448.00
IUUC-Oru-085141	Oryza rufipogon	41.77	8.00e-125	441.00
IUUC-Osa-085641	Oryza sativa	42.15	2.00e-128	453.00
IUUC-Ola-086553	Oryzias latipes	84.11	0.00e+00	1562.00
IUUC-Oga-088562	Otolemur garnettii	63.58	0.00e+00	1100.00
IUUC-Oar-090439	Ovis aries	68.60	0.00e+00	1230.00
IUUC-Psi-093942	Pelodiscus sinensis	67.34	0.00e+00	1157.00
IUUC-Pfo-097060	Poecilia formosa	83.30	0.00e+00	1569.00
IUUC-Pop-099801	Populus trichocarpa	38.24	3.00e-154	539.00
IUUC-Pca-100161	Procavia capensis	65.34	0.00e+00	792.00
IUUC-Rno-106081	Rattus norvegicus	65.63	0.00e+00	1222.00
IUUC-Sha-106937	Sarcophilus harrisii	69.16	0.00e+00	1231.00
IUUC-Sly-111746	Solanum lycopersicum	37.77	3.00e-153	535.00
IUUC-Stu-112671	Solanum tuberosum	37.68	7.00e-152	531.00
IUUC-Sar-113542	Sorex araneus	63.78	0.00e+00	1190.00
IUUC-Tae-125401	Triticum aestivum	34.02	2.00e-138	486.00
IUUC-Ttr-128778	Tursiops truncatus	66.84	0.00e+00	1202.00
IUUC-Uma-129498	Ustilago maydis	38.72	2.00e-68	254.00
IUUC-Vvi-131454	Vitis vinifera	42.19	7.00e-126	444.00
IUUC-Xtr-132305	Xenopus tropicalis	67.39	0.00e+00	1216.00
IUUC-Xma-133176	Xiphophorus maculatus	87.97	0.00e+00	999.00
IUUC-Yli-134392	Yarrowia lipolytica	45.32	6.00e-65	243.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence