iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000008880.10	ENSDART00000147896.1	ENSDARP00000123445.1
ENSDARG00000008880.10	ENSDART00000003076.9	ENSDARP00000012821.8

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.50e-58	197.1	150	628

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +G++N+gNtC++ +v+Q+L+++p +r+l+l+     +  ek++  + ++++ +++++l+ lf+ ++ s+++ v+p++ ++ l+++ +  
   Q: 150  VGIRNVGNTCWFSAVIQSLFHLPVFRRLVLNyclseRVLEKCKSHS-EKRNIAFMQELRCLFALMVGSNRRFVDPSAAVELLRDAFRT- 236
           6*******************************99988888888765.7999********************************99987. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
            + +qqD++Ef++ lld le++++                     +  +++ k+++++++lF g++      l+ +++ s  e+f +++
   Q: 237  -SEAQQDVSEFTHKLLDWLEDAFQL------------------AANGTNPEDKQNNPMVQLFYGTFV--AERLHEGEIVSNIEQFGQYP 304
           .89********************22..................23567899999************9..5678899************* PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e e+e+   +++++  +   + ++ +++klP+vL+++L+Rf+f+++ +++eki+kk+efp+ + ++
   Q: 305  LQVNGFN-----NLDECLEGAMVEGEIES---LHSDQTLS---SGQERWFSKLPPVLTFELSRFEFNQSLGRPEKIHKKLEFPQVIYMD 382
           *******.....9******9999999996...77776654...56788***************************************** PP
   S: 263  pfcts.............................................................peekqke................ 274
           +++++                                                             p     +                
   Q: 383  RYLHKnvnqthgrrgevkrlkdqltllqqklegyknygsgpakypladmlqyvlefattkptnpgsP-----Vptnppistdpssgdss 466
           *****66666666666666666666655555555555555555555555555555555555555550.....05555555555555555 PP
   S: 275  ......................................................................................... 274
                                                                                                    
   Q: 467  qteaddagssdgsgcpptatqrtpihkpftqcrppmevpvqpaphsvseeelhfirsclqrwraeventiselkasidkvsqalegmys 555
           66666666666777777777777777777777777777777777777778888888888888888888888888888888999999999 PP
   S: 275  .....kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                ++ Y+L+av+vH+G++s GHY+ay++++ ++ Wl+++D  V e+++ee ++++      ++aY+l+Y 
   Q: 556  dnslcQVPYRLHAVLVHEGQASAGHYWAYIYDHAQRrWLKYNDVLVAESTWEELVRDSYggmtnASAYCLMYI 628
           99999***************************66667****************9997779************6 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MRVEQEFEHG ETSENSSQML LNQLREITGI QDPQVLQSAL NAGQGDISHA IGLLTTQPPE 60
EEHMPEQTTT ANNEKNTSSA QNGPAKDDLQ TAIELSLQES QQAEAERREL HRALEVSAEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCACTTGA GCGTTTGTCC CTCTCGGCAT TTGTGCACTT GTGTGGGTGT GTGTGTGTGT 60
CCGTGGGGCA TATGGAGTAG GTCACACTCT GGATTCAGGG CGAATCAGTC TGGAGAATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0021551--P:central nervous system morphogenesis
GO:0000077--P:DNA damage checkpoint
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dre:567050

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	57.08	0.00e+00	766.00
IUUC-Ang-009577	Aspergillus niger	38.24	4.00e-11	64.30
IUUC-Ame-011910	Astyanax mexicanus	71.73	0.00e+00	687.00
IUUC-Bta-013377	Bos taurus	55.44	0.00e+00	734.00
IUUC-Cja-019977	Callithrix jacchus	56.70	0.00e+00	749.00
IUUC-Cpo-021817	Cavia porcellus	56.66	0.00e+00	749.00
IUUC-Cho-024717	Choloepus hoffmanni	56.71	2.00e-106	380.00
IUUC-Csv-025911	Ciona savignyi	42.11	2.00e-100	360.00
IUUC-Cme-027167	Cyanidioschyzon merolae	30.91	8.00e-16	79.70
IUUC-Dor-030955	Dipodomys ordii	53.10	0.00e+00	701.00
IUUC-Ete-032828	Echinops telfairi	54.00	1.00e-131	464.00
IUUC-Eca-034300	Equus caballus	56.64	0.00e+00	721.00
IUUC-Eeu-034458	Erinaceus europaeus	55.06	0.00e+00	703.00
IUUC-Fca-035753	Felis catus	56.98	0.00e+00	764.00
IUUC-Gmo-039593	Gadus morhua	73.21	0.00e+00	974.00
IUUC-Gac-041867	Gasterosteus aculeatus	74.60	0.00e+00	1024.00
IUUC-Ggo-045384	Gorilla gorilla	56.21	0.00e+00	751.00
IUUC-Hsa-046277	Homo sapiens	56.44	0.00e+00	755.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	61.62	2.00e-110	393.00
IUUC-Lch-049692	Latimeria chalumnae	60.61	0.00e+00	815.00
IUUC-Loc-052636	Lepisosteus oculatus	72.42	0.00e+00	1008.00
IUUC-Laf-053808	Loxodonta africana	56.28	0.00e+00	746.00
IUUC-Meu-056416	Macropus eugenii	44.69	1.00e-152	534.00
IUUC-Mdo-061955	Monodelphis domestica	53.59	0.00e+00	1144.00
IUUC-Mpu-066454	Mustela putorius furo	57.50	0.00e+00	753.00
IUUC-Nle-070044	Nomascus leucogenys	56.34	0.00e+00	751.00
IUUC-Opr-070888	Ochotona princeps	62.82	1.00e-104	375.00
IUUC-Ont-072386	Oreochromis niloticus	72.95	0.00e+00	1053.00
IUUC-Ola-086393	Oryzias latipes	70.77	0.00e+00	1005.00
IUUC-Oga-088618	Otolemur garnettii	56.78	0.00e+00	748.00
IUUC-Pma-094250	Petromyzon marinus	47.78	2.00e-73	268.00
IUUC-Pno-095093	Phaeosphaeria nodorum	42.11	4.00e-12	67.40
IUUC-Pab-098337	Pongo abelii	56.34	0.00e+00	751.00
IUUC-Pva-102226	Pteropus vampyrus	53.10	6.00e-178	618.00
IUUC-Sha-107489	Sarcophilus harrisii	57.27	0.00e+00	760.00
IUUC-Sre-115145	Sporisorium reilianum	23.36	6.00e-15	77.40
IUUC-Tru-117807	Takifugu rubripes	71.59	0.00e+00	1004.00
IUUC-Tni-119983	Tetraodon nigroviridis	71.78	0.00e+00	999.00
IUUC-Ttr-128887	Tursiops truncatus	49.78	0.00e+00	637.00
IUUC-Uma-129338	Ustilago maydis	23.10	2.00e-13	72.40
IUUC-Xma-133995	Xiphophorus maculatus	74.46	0.00e+00	1036.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence