iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-040296

Ensembl Protein ID

ENSGALP00000010524.4

UniProt Accession

E1BXA3; E1BXA3_CHICK

Genbank Protein ID

ENSGALP00000010524

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AADN04000057

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000006522.5	ENSGALT00000010538.5	ENSGALP00000010524.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.00e-16	60.1	48	103

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v +lydyea ++++L++kkG+ ++v+   eq ++W+++ + l+g++G++P+nFv++++
   Q: 48   VVLALYDYEAMHSGDLSFKKGERLQVL---EQLGEWWQARSLLTGRKGFIPSNFVARAN 103
           6889***********************...**************************987 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MGCVKSKEDS IQEKMQLGRG KKDPTSGSKQ HEDRHPGATL TAGSGDSVVL ALYDYEAMHS 60
GDLSFKKGER LQVLEQLGEW WQARSLLTGR KGFIPSNFVA RANSLEAEEW FFKSISRKDA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTTGCG TGAAGTCAAA GGAAGACAGC ATCCAAGAGA AGATGCAGTT AGGCCGTGGT 60
AAGAAGGACC CCACGTCTGG CAGCAAGCAA GTAAGTGGGA GCTGCAGTGT CCTGGGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	75.35	0.00e+00	785.00
IUUC-Apl-003285	Anas platyrhynchos	84.55	0.00e+00	893.00
IUUC-Aca-004724	Anolis carolinensis	75.49	0.00e+00	773.00
IUUC-Ame-011954	Astyanax mexicanus	72.17	0.00e+00	738.00
IUUC-Bta-013060	Bos taurus	75.35	0.00e+00	782.00
IUUC-Cja-019817	Callithrix jacchus	75.25	0.00e+00	777.00
IUUC-Cfa-020511	Canis familiaris	75.35	0.00e+00	785.00
IUUC-Cpo-022538	Cavia porcellus	73.92	0.00e+00	774.00
IUUC-Csa-024143	Chlorocebus sabaeus	78.90	0.00e+00	778.00
IUUC-Dre-028157	Danio rerio	73.80	0.00e+00	778.00
IUUC-Dno-029761	Dasypus novemcinctus	74.95	0.00e+00	785.00
IUUC-Eca-034090	Equus caballus	73.96	0.00e+00	764.00
IUUC-Fca-035937	Felis catus	74.46	0.00e+00	763.00
IUUC-Fal-036624	Ficedula albicollis	80.67	0.00e+00	860.00
IUUC-Gmo-039009	Gadus morhua	69.80	0.00e+00	733.00
IUUC-Gac-042362	Gasterosteus aculeatus	71.85	0.00e+00	763.00
IUUC-Ggo-044570	Gorilla gorilla	78.48	0.00e+00	779.00
IUUC-Hsa-046378	Homo sapiens	78.90	0.00e+00	785.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	75.15	0.00e+00	786.00
IUUC-Loc-052904	Lepisosteus oculatus	76.13	0.00e+00	807.00
IUUC-Laf-053654	Loxodonta africana	75.54	0.00e+00	788.00
IUUC-Mcc-055317	Macaca mulatta	79.11	0.00e+00	785.00
IUUC-Mga-060194	Meleagris gallopavo	94.03	0.00e+00	886.00
IUUC-Mmr-061510	Microcebus murinus	74.80	0.00e+00	782.00
IUUC-Mdo-062035	Monodelphis domestica	73.57	0.00e+00	780.00
IUUC-Mmu-064037	Mus musculus	75.45	0.00e+00	790.00
IUUC-Mpu-066874	Mustela putorius furo	75.30	0.00e+00	790.00
IUUC-Mlu-068202	Myotis lucifugus	71.77	0.00e+00	740.00
IUUC-Nle-069222	Nomascus leucogenys	75.10	0.00e+00	781.00
IUUC-Opr-070705	Ochotona princeps	73.21	0.00e+00	767.00
IUUC-Ont-072347	Oreochromis niloticus	78.97	0.00e+00	743.00
IUUC-Ocu-074490	Oryctolagus cuniculus	74.36	0.00e+00	781.00
IUUC-Ola-086521	Oryzias latipes	79.24	0.00e+00	760.00
IUUC-Oga-088153	Otolemur garnettii	75.05	0.00e+00	783.00
IUUC-Oar-090184	Ovis aries	74.12	0.00e+00	774.00
IUUC-Ptr-090505	Pan troglodytes	74.68	0.00e+00	728.00
IUUC-Pan-092260	Papio anubis	79.11	0.00e+00	785.00
IUUC-Pfo-096566	Poecilia formosa	73.32	0.00e+00	778.00
IUUC-Pva-103021	Pteropus vampyrus	75.30	0.00e+00	790.00
IUUC-Rno-105309	Rattus norvegicus	75.25	0.00e+00	789.00
IUUC-Sha-107099	Sarcophilus harrisii	73.91	0.00e+00	778.00
IUUC-Tgu-116912	Taeniopygia guttata	82.35	0.00e+00	857.00
IUUC-Tru-118449	Takifugu rubripes	79.37	0.00e+00	749.00
IUUC-Tbe-128144	Tupaia belangeri	72.89	0.00e+00	679.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence