iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066874

Ensembl Protein ID

ENSMPUP00000017776.1

UniProt Accession

M3Z2G4; M3Z2G4_MUSPF

Genbank Protein ID

ENSMPUP00000017776

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AEYP01020867

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000017886.1	ENSMPUT00000018036.1	ENSMPUP00000017776.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.50e-16	58.9	60	115

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v++lydyea + ++L+++kGd++ v+   e++++W+k+ +  + k+G +P+n+v++++
   Q: 60   IVIALYDYEAIHHEDLSFQKGDQMVVL---EESGEWWKARSLVTRKEGYIPSNYVARIN 115
           689************************...99*************************97 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MGCMKSKFLQ DRGKVSKTEP STNPHSPVYV PDPTSTSKRR PDNSNNIPPG SADVGPDDII 60
VIALYDYEAI HHEDLSFQKG DQMVVLEESG EWWKARSLVT RKEGYIPSNY VARINSLETE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCGCTCAGG GCGCGGCTAA GGAACCCAGA TGGCCTGTGG GTGCCACCGC GTCCCTGGTC 60
CTAGCCGGGG CGCACCACAG AGGCCTAGAC GCCCGCGGGT GGGGACGCGG GCGGATCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	95.64	0.00e+00	999.00
IUUC-Apl-003285	Anas platyrhynchos	79.37	0.00e+00	816.00
IUUC-Aca-004724	Anolis carolinensis	78.11	0.00e+00	793.00
IUUC-Ame-011954	Astyanax mexicanus	75.35	0.00e+00	765.00
IUUC-Bta-013060	Bos taurus	92.66	0.00e+00	981.00
IUUC-Cja-019817	Callithrix jacchus	90.50	0.00e+00	943.00
IUUC-Cfa-020511	Canis familiaris	95.24	0.00e+00	1005.00
IUUC-Cpo-022538	Cavia porcellus	89.31	0.00e+00	939.00
IUUC-Csa-024143	Chlorocebus sabaeus	90.89	0.00e+00	950.00
IUUC-Dre-028157	Danio rerio	76.48	0.00e+00	789.00
IUUC-Dno-029761	Dasypus novemcinctus	89.09	0.00e+00	947.00
IUUC-Eca-034090	Equus caballus	90.08	0.00e+00	946.00
IUUC-Fca-035937	Felis catus	90.66	0.00e+00	926.00
IUUC-Fal-036624	Ficedula albicollis	78.19	0.00e+00	813.00
IUUC-Gmo-039009	Gadus morhua	72.53	0.00e+00	752.00
IUUC-Gga-040296	Gallus gallus	75.30	0.00e+00	790.00
IUUC-Gac-042362	Gasterosteus aculeatus	73.77	0.00e+00	776.00
IUUC-Ggo-044570	Gorilla gorilla	90.50	0.00e+00	948.00
IUUC-Hsa-046378	Homo sapiens	90.69	0.00e+00	954.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	88.89	0.00e+00	942.00
IUUC-Loc-052904	Lepisosteus oculatus	77.91	0.00e+00	822.00
IUUC-Laf-053654	Loxodonta africana	90.67	0.00e+00	956.00
IUUC-Mcc-055317	Macaca mulatta	91.29	0.00e+00	958.00
IUUC-Mga-060194	Meleagris gallopavo	80.89	0.00e+00	766.00
IUUC-Mmr-061510	Microcebus murinus	89.09	0.00e+00	948.00
IUUC-Mdo-062035	Monodelphis domestica	84.58	0.00e+00	894.00
IUUC-Mmu-064037	Mus musculus	88.69	0.00e+00	946.00
IUUC-Mlu-068202	Myotis lucifugus	90.08	0.00e+00	926.00
IUUC-Nle-069222	Nomascus leucogenys	91.09	0.00e+00	952.00
IUUC-Opr-070705	Ochotona princeps	86.90	0.00e+00	932.00
IUUC-Ont-072347	Oreochromis niloticus	82.06	0.00e+00	758.00
IUUC-Ocu-074490	Oryctolagus cuniculus	88.29	0.00e+00	931.00
IUUC-Ola-086521	Oryzias latipes	81.39	0.00e+00	770.00
IUUC-Oga-088153	Otolemur garnettii	89.48	0.00e+00	950.00
IUUC-Oar-090184	Ovis aries	92.11	0.00e+00	977.00
IUUC-Ptr-090505	Pan troglodytes	86.73	0.00e+00	897.00
IUUC-Pan-092260	Papio anubis	91.09	0.00e+00	956.00
IUUC-Pma-094311	Petromyzon marinus	74.94	0.00e+00	736.00
IUUC-Pfo-096566	Poecilia formosa	75.94	0.00e+00	792.00
IUUC-Pva-103021	Pteropus vampyrus	93.65	0.00e+00	993.00
IUUC-Rno-105309	Rattus norvegicus	88.10	0.00e+00	939.00
IUUC-Sha-107099	Sarcophilus harrisii	84.62	0.00e+00	897.00
IUUC-Tgu-116912	Taeniopygia guttata	78.74	0.00e+00	810.00
IUUC-Tru-118449	Takifugu rubripes	80.18	0.00e+00	757.00
IUUC-Tae-123706	Triticum aestivum	31.92	3.00e-22	100.00
IUUC-Tur-126022	Triticum urartu	31.92	3.00e-22	100.00
IUUC-Tbe-128144	Tupaia belangeri	85.78	0.00e+00	797.00
IUUC-Xma-133902	Xiphophorus maculatus	76.09	0.00e+00	788.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence