iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000015762.2	ENSSTOT00000015759.2	ENSSTOP00000014104.2
ENSSTOG00000015762.2	ENSSTOT00000015781.2	ENSSTOP00000014122.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-89	299.7	704	1027

Active Site

Position(s)	Description	Evidence
997	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEeg..ldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgr 86
           ++dl+++l+v+f gE g   dlgGv+ ef+++l++e+ +p++g+f y e+ +++++p++ ++    e+ ++F f+G+l+g++l+++ 
   Q: 704  NEDLRRELRVSFIGEIGyeYDLGGVKTEFFYCLFEEMTRPEYGMFIYPEEASYMWFPARPKF----EEKRYF-FFGVLCGLSLFNRS 785
           6899***********97225889**************************************9....566777.99************ PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeY 173
           + ++p++ +++k+ll++  sledl+e+ p l+ksl+ +++ + +d         f v+ ++  ++++e+L+p+G++i V+++Nk++Y
   Q: 786  VANIPFPLALFKKLLDQVPSLEDLKELSPVLAKSLQTLLDDEGNDFG-----EVFYVHFNLHWDRNDENLIPNGSSIVVNQTNKRDY 867
           ***************************************77555555.....5566777789999********************** PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefssee 260
           v++ v+y+++ ++k+ +++f++Gf++v+++e++++F++eel+ +i G++++d+e+l+k+++y++gy++++p+i +Fwe+l++++ ee
   Q: 868  VSKCVDYIFNISVKTVYKEFQRGFYKVCDKEIIEIFHPEELKDVIVGNTDYDWETLEKNASYEQGYNNSHPTIVMFWEALHKLTLEE 954
           *************************************************************************************** PP
   S: 261  rkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +k+fL F+Tg++rl ++ ++++k r f+++++ ++++  +++TCf++L LP+Ys++e ++e L++Ai++++gF+
   Q: 955  KKKFLVFLTGTDRLQMKDLKNMKIR-FCCPENLNEKDPMRAQTCFSVLYLPKYSTMERVEEALQVAINNSRGFG 1027
           ***********************55.999998999*************************************96 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MEPRLRRRSR GRARSNPGRA AASRSVEPHC AGLWLFPSAS GLRSALLRRS ETTRQICCTS 60
RRLAVLERGG AGVEIHQLPP RSDGARKPKC IKLGKKMKIH SMDQGEEHML TLSSDGKLFE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTACTTCA GCTGGGGCGC TGGCTCCCAG GGGCGAAAGC GCGGGCTGGC ACGGGGTCCC 60
AGGAGCGCCA GAGGCGACCA GCTCCTGCAG GCGGCTAGCG GGGAGCGCCA CTCTCTGCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	74.62	0.00e+00	1507.00
IUUC-Bta-013080	Bos taurus	43.06	0.00e+00	738.00
IUUC-Cja-018751	Callithrix jacchus	69.86	0.00e+00	1397.00
IUUC-Cfa-020247	Canis familiaris	73.00	0.00e+00	1409.00
IUUC-Cpo-022346	Cavia porcellus	42.98	0.00e+00	745.00
IUUC-Csa-023204	Chlorocebus sabaeus	70.60	0.00e+00	1231.00
IUUC-Cho-025101	Choloepus hoffmanni	63.73	1.00e-180	626.00
IUUC-Dno-029795	Dasypus novemcinctus	65.52	0.00e+00	1008.00
IUUC-Dor-030862	Dipodomys ordii	61.57	0.00e+00	649.00
IUUC-Eca-034358	Equus caballus	71.55	0.00e+00	1384.00
IUUC-Eeu-035282	Erinaceus europaeus	58.23	9.00e-179	620.00
IUUC-Fca-036505	Felis catus	74.44	0.00e+00	1481.00
IUUC-Ggo-045445	Gorilla gorilla	68.08	0.00e+00	1286.00
IUUC-Hsa-046342	Homo sapiens	70.16	0.00e+00	1361.00
IUUC-Laf-053921	Loxodonta africana	67.60	0.00e+00	1342.00
IUUC-Mcc-054850	Macaca mulatta	70.49	0.00e+00	1234.00
IUUC-Mmr-060783	Microcebus murinus	61.15	0.00e+00	1070.00
IUUC-Mdo-061839	Monodelphis domestica	42.23	0.00e+00	657.00
IUUC-Mmu-064378	Mus musculus	39.71	0.00e+00	672.00
IUUC-Mpu-066123	Mustela putorius furo	73.02	0.00e+00	1466.00
IUUC-Mlu-067914	Myotis lucifugus	71.81	0.00e+00	1297.00
IUUC-Nle-069986	Nomascus leucogenys	70.71	0.00e+00	1387.00
IUUC-Opr-070513	Ochotona princeps	63.61	0.00e+00	915.00
IUUC-Ocu-074305	Oryctolagus cuniculus	69.46	0.00e+00	1294.00
IUUC-Oga-088780	Otolemur garnettii	44.11	0.00e+00	727.00
IUUC-Oar-089456	Ovis aries	73.17	0.00e+00	1405.00
IUUC-Ptr-091216	Pan troglodytes	69.83	0.00e+00	1177.00
IUUC-Pan-091706	Papio anubis	69.79	0.00e+00	1324.00
IUUC-Pab-098024	Pongo abelii	44.34	0.00e+00	718.00
IUUC-Pca-100320	Procavia capensis	61.69	0.00e+00	1197.00
IUUC-Pva-102646	Pteropus vampyrus	74.20	0.00e+00	1472.00
IUUC-Rno-105768	Rattus norvegicus	39.02	0.00e+00	638.00
IUUC-Sha-106525	Sarcophilus harrisii	39.20	0.00e+00	718.00
IUUC-Sar-113605	Sorex araneus	71.51	6.00e-136	478.00
IUUC-Ssc-116076	Sus scrofa	78.90	4.00e-175	607.00
IUUC-Tsy-119240	Tarsius syrichta	58.10	0.00e+00	1040.00
IUUC-Tbe-127787	Tupaia belangeri	80.98	0.00e+00	761.00
IUUC-Ttr-128191	Tursiops truncatus	71.26	0.00e+00	1380.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence