iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 549  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 636
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 637  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 722
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 723  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIVWFWQFVKEIDNEKRMRLLQFV 810
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 811  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 881
           *********************************************************************96 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MLIIFHLSCF QVCCLIDGMS DSAPQLDSMG SLTMKSQLQI TVISAKLKEN KKNWFGPSPY 60
VEVTVDGQSK KTEKCNNTNS PKWKQPLTVI VTPMSKLCFR VWSHQTLKSD VLLGTAGLDI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCATTGATTA TTATGGAGCC TTTAGGAAAG GCCAGAGATG CTAATAATAT TTCATTTATC 60
TTGTTTTCAG GTTTGCTGTC TTATTGATGG TATGTCTGAC AGTGCACCAC AGCTCGATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	94.04	0.00e+00	1571.00
IUUC-Apl-003752	Anas platyrhynchos	84.30	0.00e+00	1450.00
IUUC-Aca-005338	Anolis carolinensis	81.63	0.00e+00	1432.00
IUUC-Ame-010601	Astyanax mexicanus	87.73	0.00e+00	1119.00
IUUC-Bta-012782	Bos taurus	94.91	0.00e+00	1563.00
IUUC-Cja-018899	Callithrix jacchus	91.57	0.00e+00	1548.00
IUUC-Cfa-020648	Canis familiaris	93.79	0.00e+00	1537.00
IUUC-Cpo-022073	Cavia porcellus	94.91	0.00e+00	1606.00
IUUC-Csa-023252	Chlorocebus sabaeus	93.98	0.00e+00	1593.00
IUUC-Cho-024695	Choloepus hoffmanni	87.73	0.00e+00	1562.00
IUUC-Dre-028451	Danio rerio	75.26	0.00e+00	1297.00
IUUC-Dno-029884	Dasypus novemcinctus	93.98	0.00e+00	1606.00
IUUC-Eca-033793	Equus caballus	94.74	0.00e+00	1603.00
IUUC-Eeu-034716	Erinaceus europaeus	92.79	0.00e+00	886.00
IUUC-Fca-035605	Felis catus	95.18	0.00e+00	1602.00
IUUC-Fal-037126	Ficedula albicollis	83.77	0.00e+00	1442.00
IUUC-Gmo-038596	Gadus morhua	80.79	0.00e+00	1008.00
IUUC-Gga-040832	Gallus gallus	84.14	0.00e+00	1459.00
IUUC-Gac-041658	Gasterosteus aculeatus	87.50	0.00e+00	1129.00
IUUC-Ggo-044535	Gorilla gorilla	90.54	0.00e+00	1567.00
IUUC-Hsa-046564	Homo sapiens	90.61	0.00e+00	1587.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	93.75	0.00e+00	1548.00
IUUC-Kpa-049273	Komagataella pastoris	49.05	5.00e-163	568.00
IUUC-Lch-050454	Latimeria chalumnae	92.64	0.00e+00	1169.00
IUUC-Loc-052647	Lepisosteus oculatus	74.26	0.00e+00	1350.00
IUUC-Laf-054383	Loxodonta africana	94.93	0.00e+00	1612.00
IUUC-Mcc-055532	Macaca mulatta	93.98	0.00e+00	1595.00
IUUC-Mga-059661	Meleagris gallopavo	84.25	0.00e+00	1449.00
IUUC-Mmr-061135	Microcebus murinus	95.02	0.00e+00	1639.00
IUUC-Mdo-062505	Monodelphis domestica	86.73	0.00e+00	1496.00
IUUC-Mmu-063375	Mus musculus	98.50	0.00e+00	1638.00
IUUC-Mpu-066203	Mustela putorius furo	93.95	0.00e+00	1574.00
IUUC-Mlu-067837	Myotis lucifugus	94.72	0.00e+00	1603.00
IUUC-Nle-069244	Nomascus leucogenys	94.68	0.00e+00	1587.00
IUUC-Opr-070585	Ochotona princeps	89.06	0.00e+00	1543.00
IUUC-Ont-071798	Oreochromis niloticus	87.60	0.00e+00	1137.00
IUUC-Ocu-074298	Oryctolagus cuniculus	95.37	0.00e+00	1612.00
IUUC-Ola-086526	Oryzias latipes	69.44	0.00e+00	1302.00
IUUC-Oga-088167	Otolemur garnettii	88.56	0.00e+00	1472.00
IUUC-Oar-090316	Ovis aries	78.17	0.00e+00	1175.00
IUUC-Ptr-090819	Pan troglodytes	89.93	0.00e+00	1550.00
IUUC-Pan-092454	Papio anubis	93.89	0.00e+00	1598.00
IUUC-Psi-093319	Pelodiscus sinensis	82.60	0.00e+00	1408.00
IUUC-Pfo-097346	Poecilia formosa	84.35	0.00e+00	1105.00
IUUC-Pab-097580	Pongo abelii	83.87	0.00e+00	1427.00
IUUC-Pca-100923	Procavia capensis	77.78	0.00e+00	1326.00
IUUC-Pva-103209	Pteropus vampyrus	93.87	0.00e+00	1537.00
IUUC-Sha-107175	Sarcophilus harrisii	87.83	0.00e+00	1493.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	45.82	6.00e-160	558.00
IUUC-Spo-108171	Schizosaccharomyces pombe	50.53	3.00e-162	565.00
IUUC-Sar-113761	Sorex araneus	84.79	0.00e+00	1461.00
IUUC-Tgu-116632	Taeniopygia guttata	81.15	0.00e+00	1333.00
IUUC-Tru-118442	Takifugu rubripes	88.93	0.00e+00	1120.00
IUUC-Tsy-119198	Tarsius syrichta	88.66	0.00e+00	1479.00
IUUC-Tni-120168	Tetraodon nigroviridis	86.35	0.00e+00	1055.00
IUUC-Tbe-127756	Tupaia belangeri	76.02	0.00e+00	1262.00
IUUC-Ttr-128504	Tursiops truncatus	88.56	0.00e+00	1142.00
IUUC-Vpa-130103	Vicugna pacos	80.57	0.00e+00	1363.00
IUUC-Xtr-132885	Xenopus tropicalis	75.74	0.00e+00	1366.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence