iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-116632

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

ABQF01052203

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000003516.1	ENSTGUT00000003702.1	ENSTGUP00000003662.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-136	454.2	525	857

Active Site

Position(s)	Description	Evidence
826	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 525  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 612
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k + l+dle+vdpe+y+sl ++ken   diee+gl++ fsv++eilge+k+++Lkp+G+ni+Vt+eNke+Y++lv+e
   Q: 613  GFSLPFYKRILNKAVGLKDLESVDPEFYNSLIWVKEN---DIEECGLEMFFSVDKEILGEIKSHDLKPNGSNIQVTEENKEDYIRLVAE 698
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d++++t y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 699  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHTIYRH-YTRTSRQIVWFWQFVKEIDNEKRMRLLQFV 786
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+++e+lkekLl+Aieet+gF++
   Q: 787  TGTCRLPVGGFADLMgingPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKNYEQLKEKLLFAIEETEGFGQ 857
           *********************************************************************96 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

MAGSGSRSGP ASGLSMKSQL QITVISAKLK EKNKWFGPSP YVEVSVDGQS KKTEKCNNTN 60
SPKWKQHLTV IVTPVSKLNF RVWSHQTLKS DVLLGSAALD IHETLKSNSM KLEQVVVTLH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGGCA GTGGGTCCAG ATCAGGACCA GCCAGTGGGT TGTCCATGAA ATCACAGCTT 60
CAGATCACTG GTGAGCCTTC TGAAACTACC TGTCTTTTCT GCTTAGAAAT GTGATAGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	78.95	0.00e+00	1319.00
IUUC-Apl-003752	Anas platyrhynchos	87.77	0.00e+00	1449.00
IUUC-Aca-005338	Anolis carolinensis	80.41	0.00e+00	1334.00
IUUC-Aly-006083	Arabidopsis lyrata	45.88	3.00e-92	335.00
IUUC-Ath-007472	Arabidopsis thaliana	45.88	5.00e-92	334.00
IUUC-Ame-010601	Astyanax mexicanus	82.14	0.00e+00	1028.00
IUUC-Bta-012782	Bos taurus	89.53	0.00e+00	1080.00
IUUC-Cja-018899	Callithrix jacchus	89.10	0.00e+00	1094.00
IUUC-Cfa-020648	Canis familiaris	77.75	0.00e+00	1283.00
IUUC-Cpo-022073	Cavia porcellus	80.09	0.00e+00	1340.00
IUUC-Csa-023252	Chlorocebus sabaeus	79.40	0.00e+00	1321.00
IUUC-Cho-024695	Choloepus hoffmanni	82.51	0.00e+00	1132.00
IUUC-Cne-026849	Cryptococcus neoformans	48.06	4.00e-159	555.00
IUUC-Cme-027267	Cyanidioschyzon merolae	43.31	5.00e-85	309.00
IUUC-Dre-028451	Danio rerio	72.53	0.00e+00	1212.00
IUUC-Dno-029884	Dasypus novemcinctus	78.61	0.00e+00	1341.00
IUUC-Eca-033793	Equus caballus	79.05	0.00e+00	1329.00
IUUC-Eeu-034716	Erinaceus europaeus	90.17	0.00e+00	868.00
IUUC-Fca-035605	Felis catus	79.88	0.00e+00	1341.00
IUUC-Fal-037126	Ficedula albicollis	90.78	0.00e+00	1498.00
IUUC-Gmo-038596	Gadus morhua	75.26	0.00e+00	921.00
IUUC-Gga-040832	Gallus gallus	87.14	0.00e+00	1460.00
IUUC-Gac-041658	Gasterosteus aculeatus	82.08	0.00e+00	1029.00
IUUC-Ggo-044535	Gorilla gorilla	76.38	0.00e+00	1286.00
IUUC-Hsa-046564	Homo sapiens	76.35	0.00e+00	1315.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	88.42	0.00e+00	1091.00
IUUC-Kpa-049273	Komagataella pastoris	46.33	2.00e-161	562.00
IUUC-Lch-050454	Latimeria chalumnae	73.87	0.00e+00	1291.00
IUUC-Loc-052647	Lepisosteus oculatus	70.29	0.00e+00	1239.00
IUUC-Laf-054383	Loxodonta africana	80.32	0.00e+00	1334.00
IUUC-Mcc-055532	Macaca mulatta	79.17	0.00e+00	1319.00
IUUC-Mla-058996	Melampsora laricipopulina	52.28	2.00e-148	519.00
IUUC-Mga-059661	Meleagris gallopavo	87.14	0.00e+00	1453.00
IUUC-Mmr-061135	Microcebus murinus	80.21	0.00e+00	1345.00
IUUC-Mdo-062505	Monodelphis domestica	78.09	0.00e+00	1341.00
IUUC-Mmu-063375	Mus musculus	89.27	0.00e+00	1100.00
IUUC-Mpu-066203	Mustela putorius furo	79.19	0.00e+00	1321.00
IUUC-Mlu-067837	Myotis lucifugus	80.56	0.00e+00	1332.00
IUUC-Nle-069244	Nomascus leucogenys	79.40	0.00e+00	1318.00
IUUC-Opr-070585	Ochotona princeps	88.76	0.00e+00	1090.00
IUUC-Ont-071798	Oreochromis niloticus	83.53	0.00e+00	1043.00
IUUC-Oan-073679	Ornithorhynchus anatinus	74.70	0.00e+00	718.00
IUUC-Ocu-074298	Oryctolagus cuniculus	80.21	0.00e+00	1333.00
IUUC-Oga-088167	Otolemur garnettii	76.06	0.00e+00	1292.00
IUUC-Oar-090316	Ovis aries	67.19	0.00e+00	737.00
IUUC-Ptr-090819	Pan troglodytes	75.44	0.00e+00	1276.00
IUUC-Pan-092454	Papio anubis	79.17	0.00e+00	1318.00
IUUC-Psi-093319	Pelodiscus sinensis	81.27	0.00e+00	1359.00
IUUC-Pfo-096937	Poecilia formosa	83.65	0.00e+00	1030.00
IUUC-Pab-097580	Pongo abelii	74.39	0.00e+00	1274.00
IUUC-Pop-099613	Populus trichocarpa	44.74	4.00e-94	340.00
IUUC-Pca-100923	Procavia capensis	75.94	0.00e+00	971.00
IUUC-Pva-103209	Pteropus vampyrus	77.31	0.00e+00	1270.00
IUUC-Pgr-103620	Puccinia graminis	52.28	2.00e-147	515.00
IUUC-Rno-104924	Rattus norvegicus	79.17	0.00e+00	1320.00
IUUC-Sha-107175	Sarcophilus harrisii	80.62	0.00e+00	1335.00
IUUC-Sar-113761	Sorex araneus	89.53	0.00e+00	1079.00
IUUC-Tru-118442	Takifugu rubripes	84.06	0.00e+00	1035.00
IUUC-Tsy-119198	Tarsius syrichta	72.19	0.00e+00	1207.00
IUUC-Tni-120168	Tetraodon nigroviridis	82.01	0.00e+00	969.00
IUUC-Tbe-127756	Tupaia belangeri	84.65	0.00e+00	844.00
IUUC-Ttr-128504	Tursiops truncatus	70.39	0.00e+00	907.00
IUUC-Vpa-130103	Vicugna pacos	75.13	0.00e+00	896.00
IUUC-Xtr-132885	Xenopus tropicalis	72.27	0.00e+00	1273.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence