iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089233

Ensembl Protein ID

ENSOARP00000005192.1

UniProt Accession

W5P440; W5P440_SHEEP

Genbank Protein ID

ENSOARP00000005192

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01071302

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000004840.1	ENSOART00000005279.1	ENSOARP00000005192.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.50e-101	337.7	733	1056

Active Site

Position(s)	Description	Evidence
1025	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 733  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDL 814
           78999***********************************************88877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sledl+e+ p++ +s+++++++ e+d+ee+ ++l+f+++ e++g t+++eL+ +G+++ V+++N++e+v+++
   Q: 815  HFPLALYKKLLKKKPSLEDLKELVPDVGRSMQQLLDYPEDDVEET-FCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAY 900
           *************************************99999997.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af++Gf++v+  ++l+lF+++el+ ++ G++++d+++l+k+t+ykg+y +++p+i++Fwev++e+  e++k+f
   Q: 901  VDYIFNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKMFWEVFHELPLEKKKQF 987
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++l     vi+   + ++ lP s+TCfn+L+LP+Y+ ke+l++kL+ Ai++++gF+l
   Q: 988  LLFLTGSDRIPILGMKSLI---LVIQStGGGEEYLPVSHTCFNLLDLPKYTDKETLRSKLIQAIDHNEGFSL 1056
           ******************9...7777758889**************************************86 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FVNKKVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACATAGGGAC ACCACCAACT TGCCAGTGTT TCAGAAGGGA GTTTATTATT GAAGCTGGAA 60
GACCAGAAGA ATCACAAACA TGTTGTGCTG GGGAAATGCT TCTTTTGGAC AGCTAGGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

KEGG

oas:101103532

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	98.58	0.00e+00	2019.00
IUUC-Apl-003295	Anas platyrhynchos	88.56	0.00e+00	1875.00
IUUC-Aca-004336	Anolis carolinensis	86.51	0.00e+00	1828.00
IUUC-Ame-010768	Astyanax mexicanus	73.16	0.00e+00	1572.00
IUUC-Bta-013279	Bos taurus	99.81	0.00e+00	2045.00
IUUC-Cja-019023	Callithrix jacchus	97.45	0.00e+00	1998.00
IUUC-Cfa-021074	Canis familiaris	98.77	0.00e+00	2024.00
IUUC-Cpo-021461	Cavia porcellus	95.66	0.00e+00	1960.00
IUUC-Csa-024261	Chlorocebus sabaeus	98.11	0.00e+00	2012.00
IUUC-Cho-024513	Choloepus hoffmanni	77.58	0.00e+00	1485.00
IUUC-Cin-025232	Ciona intestinalis	42.63	0.00e+00	813.00
IUUC-Dre-028829	Danio rerio	74.72	0.00e+00	1562.00
IUUC-Dno-029445	Dasypus novemcinctus	94.93	0.00e+00	1630.00
IUUC-Dor-030158	Dipodomys ordii	95.82	0.00e+00	869.00
IUUC-Dme-032103	Drosophila melanogaster	45.07	0.00e+00	890.00
IUUC-Ete-033072	Echinops telfairi	86.85	0.00e+00	1733.00
IUUC-Eca-033317	Equus caballus	96.50	0.00e+00	1971.00
IUUC-Fca-035682	Felis catus	98.20	0.00e+00	2003.00
IUUC-Fal-036969	Ficedula albicollis	87.13	0.00e+00	1850.00
IUUC-Gmo-038671	Gadus morhua	73.47	0.00e+00	1565.00
IUUC-Gga-041174	Gallus gallus	88.27	0.00e+00	1875.00
IUUC-Gac-042600	Gasterosteus aculeatus	73.87	0.00e+00	1513.00
IUUC-Gma-043616	Glycine max	36.68	8.00e-52	197.00
IUUC-Ggo-044589	Gorilla gorilla	97.54	0.00e+00	2032.00
IUUC-Hsa-046772	Homo sapiens	97.54	0.00e+00	2031.00
IUUC-Lch-050147	Latimeria chalumnae	80.46	0.00e+00	1432.00
IUUC-Loc-052684	Lepisosteus oculatus	81.27	0.00e+00	1717.00
IUUC-Laf-053844	Loxodonta africana	97.35	0.00e+00	2004.00
IUUC-Mcc-055531	Macaca mulatta	95.84	0.00e+00	1997.00
IUUC-Mga-060151	Meleagris gallopavo	87.67	0.00e+00	1561.00
IUUC-Mmr-060954	Microcebus murinus	97.82	0.00e+00	2007.00
IUUC-Mdo-062246	Monodelphis domestica	91.85	0.00e+00	1769.00
IUUC-Mmu-063369	Mus musculus	95.84	0.00e+00	1976.00
IUUC-Mpu-065936	Mustela putorius furo	98.47	0.00e+00	1862.00
IUUC-Mlu-067326	Myotis lucifugus	97.63	0.00e+00	1967.00
IUUC-Nle-069453	Nomascus leucogenys	97.07	0.00e+00	1982.00
IUUC-Ont-071720	Oreochromis niloticus	74.81	0.00e+00	1571.00
IUUC-Oan-073464	Ornithorhynchus anatinus	92.77	0.00e+00	1794.00
IUUC-Ocu-074207	Oryctolagus cuniculus	95.26	0.00e+00	1843.00
IUUC-Ola-086762	Oryzias latipes	73.77	0.00e+00	1526.00
IUUC-Oga-088435	Otolemur garnettii	97.63	0.00e+00	2006.00
IUUC-Ptr-091368	Pan troglodytes	97.73	0.00e+00	2034.00
IUUC-Pan-092300	Papio anubis	98.11	0.00e+00	2012.00
IUUC-Psi-093406	Pelodiscus sinensis	89.97	0.00e+00	1902.00
IUUC-Pma-094113	Petromyzon marinus	71.89	0.00e+00	1143.00
IUUC-Ppa-095354	Physcomitrella patens	32.57	8.00e-147	514.00
IUUC-Pfo-097021	Poecilia formosa	73.23	0.00e+00	1582.00
IUUC-Pab-098327	Pongo abelii	97.82	0.00e+00	2036.00
IUUC-Pca-101075	Procavia capensis	95.80	0.00e+00	818.00
IUUC-Pva-102909	Pteropus vampyrus	86.85	0.00e+00	1700.00
IUUC-Rno-105457	Rattus norvegicus	96.69	0.00e+00	2000.00
IUUC-Sha-106632	Sarcophilus harrisii	93.09	0.00e+00	1941.00
IUUC-Sar-113679	Sorex araneus	88.33	0.00e+00	1143.00
IUUC-Tgu-116849	Taeniopygia guttata	83.54	0.00e+00	1748.00
IUUC-Tru-118206	Takifugu rubripes	72.80	0.00e+00	1476.00
IUUC-Tsy-119521	Tarsius syrichta	83.25	0.00e+00	1609.00
IUUC-Tni-120233	Tetraodon nigroviridis	71.93	0.00e+00	1463.00
IUUC-Tbe-127941	Tupaia belangeri	80.50	0.00e+00	1362.00
IUUC-Ttr-128926	Tursiops truncatus	99.36	0.00e+00	1201.00
IUUC-Vpa-130448	Vicugna pacos	98.58	0.00e+00	2015.00
IUUC-Xtr-132719	Xenopus tropicalis	70.60	0.00e+00	1382.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence