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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045838
UUCD1 version UUC-HoS-00378
Ensembl Protein ID ENSP00000267460.4
UniProt Accession Q9HAT8; B2RDY5; PELI2_HUMAN
Genbank Protein ID AAG15390.1; BAG38082.1; EAW80689.1; AAH09476.1
Protein Name E3 ubiquitin-protein ligase pellino homolog 2; RING-type E3 ubiquitin transferase pellino homolog 2
Genbank Nucleotide ID AF302502; AK315727; CH471061; BC009476
Gene Name PELI2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000139946.9 ENST00000267460.8 ENSP00000267460.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPHOSIDABioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 16884718; 17997719
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.012 17.7 305 339
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 9    kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           k+++  l+CgHv   +  ++w ++++ + +e  CP Cr
   Q: 305  KQPWAYLSCGHV---HGYHNWGHRSDTEANERECPMCR 339
           34456799**98...445689****************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
 E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.
Protein Sequence
(Fasta)
MFSPGQEEHC APNKEPVKYG ELVVLGYNGA LPNGDRGRRK SRFALYKRPK ANGVKPSTVH 60
VISTPQASKA ISCKGQHSIS YTLSRNQTVV VEYTHDKDTD MFQVGRSTES PIDFVVTDTI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045838|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
AATTTTCTAG ACGCCTTTCT GCTTGGTTTT GGAAGGGGAG GCACCCAAGT GGGTGTGTGC 60
GACACCTCTA GTTGTAAGCC GGGACACAGT GACGTCGAGA GAGCGCTATT CTACTCGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045838|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR006800--Pellino_fam
IPR013083--Znf_RING/FYVE/PHD
Pfam

PF04710--Pellino
Gene Ontology

GO:0005829--C:cytosol
GO:0004674--F:protein serine/threonine kinase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0006955--P:immune response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410--P:positive regulation of MAPK cascade
GO:0001934--P:positive regulation of protein phosphorylation
GO:0000209--P:protein polyubiquitination
GO:0008063--P:Toll signaling pathway
KEGG hsa:57161
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001453 Ailuropoda melanoleuca 98.49 0.00e+00 823.00
IUUC-Aca-004232 Anolis carolinensis 95.02 0.00e+00 806.00
IUUC-Ame-011632 Astyanax mexicanus 83.18 0.00e+00 766.00
IUUC-Bta-012385 Bos taurus 98.81 0.00e+00 874.00
IUUC-Bol-015987 Brassica oleracea 29.11 4.00e-03 32.30
IUUC-Cja-019254 Callithrix jacchus 98.76 0.00e+00 838.00
IUUC-Cfa-021104 Canis familiaris 98.63 0.00e+00 756.00
IUUC-Cpo-021812 Cavia porcellus 96.43 0.00e+00 856.00
IUUC-Csa-024149 Chlorocebus sabaeus 100.00 0.00e+00 883.00
IUUC-Dre-027746 Danio rerio 84.35 0.00e+00 769.00
IUUC-Dno-029620 Dasypus novemcinctus 99.49 0.00e+00 825.00
IUUC-Dme-031916 Drosophila melanogaster 60.24 1.00e-145 509.00
IUUC-Eeu-034920 Erinaceus europaeus 98.98 0.00e+00 823.00
IUUC-Fal-037288 Ficedula albicollis 93.48 0.00e+00 796.00
IUUC-Ggr-039890 Gaeumannomyces graminis 35.48 6.30e-02 32.30
IUUC-Gga-040983 Gallus gallus 96.67 0.00e+00 861.00
IUUC-Ggo-045497 Gorilla gorilla 99.25 0.00e+00 830.00
IUUC-Itr-048810 Ictidomys tridecemlineatus 98.49 0.00e+00 822.00
IUUC-Lch-050683 Latimeria chalumnae 93.57 0.00e+00 843.00
IUUC-Loc-052256 Lepisosteus oculatus 85.85 0.00e+00 774.00
IUUC-Laf-053518 Loxodonta africana 95.69 0.00e+00 822.00
IUUC-Mcc-054979 Macaca mulatta 100.00 0.00e+00 828.00
IUUC-Meu-056175 Macropus eugenii 85.95 0.00e+00 750.00
IUUC-Mga-059681 Meleagris gallopavo 96.70 0.00e+00 808.00
IUUC-Mmr-060621 Microcebus murinus 99.43 0.00e+00 738.00
IUUC-Mdo-063039 Monodelphis domestica 94.52 0.00e+00 839.00
IUUC-Mmu-063345 Mus musculus 95.24 0.00e+00 842.00
IUUC-Mpu-065710 Mustela putorius furo 97.52 0.00e+00 828.00
IUUC-Nle-069775 Nomascus leucogenys 99.25 0.00e+00 830.00
IUUC-Ont-071567 Oreochromis niloticus 83.73 0.00e+00 753.00
IUUC-Ocu-073835 Oryctolagus cuniculus 96.19 0.00e+00 803.00
IUUC-Ola-087060 Oryzias latipes 82.78 0.00e+00 750.00
IUUC-Olu-087734 Ostreococcus lucimarinus 28.85 1.20e-01 30.80
IUUC-Oga-087942 Otolemur garnettii 97.14 0.00e+00 859.00
IUUC-Ptr-091160 Pan troglodytes 99.76 0.00e+00 881.00
IUUC-Pan-091744 Papio anubis 99.76 0.00e+00 882.00
IUUC-Psi-093246 Pelodiscus sinensis 96.19 0.00e+00 806.00
IUUC-Pma-094346 Petromyzon marinus 64.16 7.00e-157 546.00
IUUC-Pfo-096874 Poecilia formosa 83.02 0.00e+00 755.00
IUUC-Pab-097719 Pongo abelii 99.76 0.00e+00 883.00
IUUC-Pop-098823 Populus trichocarpa 28.89 3.40e-02 31.60
IUUC-Pca-100285 Procavia capensis 96.90 0.00e+00 865.00
IUUC-Pva-102764 Pteropus vampyrus 98.33 0.00e+00 872.00
IUUC-Rno-104901 Rattus norvegicus 95.95 0.00e+00 848.00
IUUC-Sha-107581 Sarcophilus harrisii 93.78 0.00e+00 802.00
IUUC-Sbi-114200 Sorghum bicolor 28.57 1.30e-01 30.40
IUUC-Ssc-116145 Sus scrofa 99.29 0.00e+00 879.00
IUUC-Tgu-117213 Taeniopygia guttata 90.86 0.00e+00 767.00
IUUC-Tni-119678 Tetraodon nigroviridis 83.49 0.00e+00 761.00
IUUC-Tbe-127954 Tupaia belangeri 99.75 0.00e+00 826.00
IUUC-Ttr-129271 Tursiops truncatus 98.10 0.00e+00 854.00
IUUC-Vpa-130609 Vicugna pacos 97.95 0.00e+00 802.00
IUUC-Vvi-131421 Vitis vinifera 31.37 2.30e-02 31.20
IUUC-Xtr-132962 Xenopus tropicalis 91.43 0.00e+00 822.00
IUUC-Xma-133783 Xiphophorus maculatus 83.49 0.00e+00 758.00
Created Date 25-Jun-2017

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