iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028106

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

CR848729

Gene Name

usp45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000075013.4	ENSDART00000137232.1	ENSDARP00000118184.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.00e-87	292.7	192	801

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp..kepkg............ellkslqklfeelwkskkkavsprel 73
           +G++NlgNtC++N+v+Q Ls+++ l +l+ +  +k +k++ + +  +   +            +l++++  +++++ +s k+ vsp+ l
   Q: 192  KGINNLGNTCFFNAVMQNLSQTHMLNDLIQDvkEKGHKMKISPSteT---NlgsltvtlpspePLTSAMFLFLQSMKESGKGPVSPKIL 277
           59***************************995533444444333330...1456666666666************************** PP
   S: 74   lkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikc 156
           +++l+++a++f+gy+qqD+qE+l++lld+++ e +k+ +  + +++++ ++++ de      + + k+  + ++++++F g+l+s+i+c
   Q: 278  FNQLCQKAPRFKGYQQQDSQELLHYLLDSMRVEETKRIKAGILKAFNNPTEKTADEetkrqvKAYGKEGVKLNFVDRIFVGELTSTIMC 366
           *******************************99989666666666666666666663333335566666666***************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke............................................................ 185
           +ec+++s+ +e f+d+slp+ +++ +k++                                                            
   Q: 367  EECEHISTVKEAFIDISLPIIEERISKPTnparlgksgreqdsltshddslaahsqanrnsrrlsgqklqsrhsstshddrgpdtvssr 455
           ************************99988************************************************************ PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 456  qeedlcvagrglssyrtdtmgsqsdcsekesnlqdssndadseasesewspripsvsshsstsdktsitttlsttthnpslksnpsstp 544
           ***************************************************************************************** PP
   S: 186  ......................................................................slqdcLesftkeeelegen 204
                                                                                 s+q+cL++ft+ e l g+n
   Q: 545  lpsirpqqggaveqlvsavsklglvhtstdtlpishsqeelsetrdrdrqhhqgafqvlchsytpsskecSVQSCLHQFTSIELLMGNN 633
           ***************************************************************************************** PP
   S: 205  kyycekckkkqe................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..k 275
           k+ ce+c+++++                a+k++ ++ lP+v +lhLkRf  ++++++ +k+n++v+fpl Ldl+pfc+ ++++  +  +
   Q: 634  KLLCENCTDRRQrqmkrsdkkaekvytsARKQMLISALPPVVTLHLKRF--HQAGMNLRKVNRHVDFPLLLDLAPFCSATCKNLGSgeR 720
           ********99999999999999999999*********************..9999************************8776544559 PP
   S: 276  kkYeLiavvvHsGslssGHYvayvkn......................ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           + Y+L+++v HsGs+++GHY ayvk                        +g+W++++D++V++v+e++vl+   s+aY+lfY++
   Q: 721  VLYSLYGIVEHSGSMRGGHYAAYVKVrtpqrkpeqrrnqsgsreacsaPQGQWVYVSDTTVQTVPESRVLN---SQAYLLFYEE 801
           **************************99999999999988888888888999*******************...********96 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MRLKDPFSLK TADMTKRSNK PKKPRDEDSS DEVGGLTCQH VSRAVDLSSV KKAVTGSLWS 60
VCSDCLKERN VLEGETAGAH DILVCLKCGF QGCNQAEVQH STKHQQAHHS DSHCITISLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCACGTGA CACATCTGAT ACTTGTGCTT TCTGTTCTTC CCTAAATGCC AGTAAATACG 60
CCGAATAACT CTCTTAATCA AAACCGTAAC TGCATCTCGG GATTTTTCGA TTAATGAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dre:564004

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	58.99	4.00e-123	435.00
IUUC-Apl-003512	Anas platyrhynchos	54.63	0.00e+00	864.00
IUUC-Aca-004284	Anolis carolinensis	60.68	6.00e-154	538.00
IUUC-Ath-006732	Arabidopsis thaliana	26.75	9.00e-30	126.00
IUUC-Ame-010735	Astyanax mexicanus	74.73	0.00e+00	628.00
IUUC-Bta-012880	Bos taurus	53.16	0.00e+00	766.00
IUUC-Bol-015941	Brassica oleracea	29.85	5.00e-27	117.00
IUUC-Bra-016751	Brassica rapa	29.70	5.00e-26	114.00
IUUC-Cja-019144	Callithrix jacchus	52.47	0.00e+00	798.00
IUUC-Cfa-020971	Canis familiaris	59.90	3.00e-142	499.00
IUUC-Cpo-022497	Cavia porcellus	58.30	1.00e-142	500.00
IUUC-Csa-023910	Chlorocebus sabaeus	52.96	0.00e+00	745.00
IUUC-Cho-024358	Choloepus hoffmanni	44.55	1.00e-71	264.00
IUUC-Dor-030438	Dipodomys ordii	45.77	6.00e-100	358.00
IUUC-Dme-031870	Drosophila melanogaster	50.96	2.00e-36	148.00
IUUC-Ete-032736	Echinops telfairi	53.48	3.00e-113	402.00
IUUC-Eca-034211	Equus caballus	58.66	5.00e-147	515.00
IUUC-Eeu-034797	Erinaceus europaeus	67.23	1.00e-68	254.00
IUUC-Fca-035947	Felis catus	60.47	1.00e-132	467.00
IUUC-Fal-037199	Ficedula albicollis	56.66	7.00e-165	574.00
IUUC-Gmo-039228	Gadus morhua	82.74	0.00e+00	668.00
IUUC-Gga-040823	Gallus gallus	52.22	4.00e-131	461.00
IUUC-Gac-042406	Gasterosteus aculeatus	69.24	0.00e+00	1060.00
IUUC-Ggo-045402	Gorilla gorilla	52.59	0.00e+00	801.00
IUUC-Hsa-046430	Homo sapiens	51.97	0.00e+00	801.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	50.29	4.00e-118	418.00
IUUC-Lch-049547	Latimeria chalumnae	54.46	6.00e-146	511.00
IUUC-Loc-052842	Lepisosteus oculatus	67.18	0.00e+00	1071.00
IUUC-Laf-053988	Loxodonta africana	51.52	0.00e+00	796.00
IUUC-Mcc-055491	Macaca mulatta	52.31	0.00e+00	783.00
IUUC-Meu-056256	Macropus eugenii	46.98	3.00e-127	449.00
IUUC-Mla-059026	Melampsora laricipopulina	33.33	3.00e-19	90.50
IUUC-Mga-059833	Meleagris gallopavo	47.58	8.00e-133	467.00
IUUC-Mvi-060391	Microbotryum violaceum	32.04	4.00e-15	77.00
IUUC-Mmr-060952	Microcebus murinus	55.15	6.00e-148	518.00
IUUC-Mdo-062642	Monodelphis domestica	53.78	0.00e+00	824.00
IUUC-Mmu-063945	Mus musculus	52.23	0.00e+00	791.00
IUUC-Mpu-065944	Mustela putorius furo	60.15	2.00e-140	493.00
IUUC-Mlu-067049	Myotis lucifugus	51.49	0.00e+00	753.00
IUUC-Nle-069828	Nomascus leucogenys	52.88	0.00e+00	803.00
IUUC-Opr-070672	Ochotona princeps	47.72	9.00e-89	321.00
IUUC-Ont-072121	Oreochromis niloticus	69.58	0.00e+00	1060.00
IUUC-Oan-073656	Ornithorhynchus anatinus	57.20	3.00e-168	585.00
IUUC-Ocu-074323	Oryctolagus cuniculus	62.29	8.00e-146	511.00
IUUC-Ola-087238	Oryzias latipes	70.72	0.00e+00	1128.00
IUUC-Oga-088379	Otolemur garnettii	50.66	0.00e+00	749.00
IUUC-Oar-089718	Ovis aries	59.76	6.00e-147	514.00
IUUC-Ptr-091358	Pan troglodytes	52.21	0.00e+00	802.00
IUUC-Pan-092023	Papio anubis	53.07	0.00e+00	802.00
IUUC-Psi-093256	Pelodiscus sinensis	54.42	0.00e+00	822.00
IUUC-Ppa-095622	Physcomitrella patens	29.85	1.00e-30	129.00
IUUC-Pfo-097285	Poecilia formosa	65.34	0.00e+00	969.00
IUUC-Pab-098539	Pongo abelii	53.12	0.00e+00	814.00
IUUC-Pca-100610	Procavia capensis	54.23	3.00e-101	363.00
IUUC-Pva-102985	Pteropus vampyrus	61.46	5.00e-135	475.00
IUUC-Rno-105538	Rattus norvegicus	60.67	7.00e-148	518.00
IUUC-Sha-107022	Sarcophilus harrisii	61.27	2.00e-143	503.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	30.05	2.00e-20	94.40
IUUC-Spo-108149	Schizosaccharomyces pombe	32.50	6.00e-24	106.00
IUUC-Sit-110283	Setaria italica	37.11	1.00e-24	108.00
IUUC-Sar-113637	Sorex araneus	59.61	3.00e-144	505.00
IUUC-Ssc-115870	Sus scrofa	53.47	0.00e+00	801.00
IUUC-Tgu-116907	Taeniopygia guttata	55.02	0.00e+00	863.00
IUUC-Tru-117835	Takifugu rubripes	59.90	0.00e+00	874.00
IUUC-Tsy-118869	Tarsius syrichta	52.37	0.00e+00	700.00
IUUC-Tni-119716	Tetraodon nigroviridis	67.17	0.00e+00	830.00
IUUC-Tca-121701	Theobroma cacao	31.53	2.00e-34	141.00
IUUC-Tbe-128041	Tupaia belangeri	68.26	6.00e-92	332.00
IUUC-Ttr-128901	Tursiops truncatus	50.36	0.00e+00	741.00
IUUC-Vpa-130331	Vicugna pacos	52.01	0.00e+00	717.00
IUUC-Xtr-131794	Xenopus tropicalis	49.28	0.00e+00	719.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence