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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063218
Ensembl Protein ID ENSMUSP00000106981.2
UniProt Accession Q99JB8; Q9EQP9; PACN3_MOUSE
Genbank Protein ID AAG31022.1; AAK29208.1; AAH03884.1
Protein Name Protein kinase C and casein kinase II substrate protein 3
Genbank Nucleotide ID AF149824; AF242531; BC003884
Gene Name Pacsin3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000027257.13 ENSMUST00000111349.8 ENSMUSP00000106981.2
ENSMUSG00000027257.13 ENSMUST00000128684.1 ENSMUSP00000118915.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.60e-13 50.8 367 421
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +v++lydy +q+ deL++++G+ +l +  ee ++gW++g+   +g+ Gl P+n+ve 
   Q: 367  RVRALYDYAGQEADELSFRAGEELLKM-SEEDEQGWCQGQ-LQSGRIGLYPANYVEC 421
           689********************9999.999********7.99************86 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.
 Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.
Protein Sequence
(Fasta)
MAPEEDAGGE VLGGSFWEAG NYRRTVQRVE DGHRLCGDLV SCFQERARIE KAYAQQLADW 60
ARKWRGAVEK GPQYGTLEKA WHAFFTAAER LSELHLEVRE KLHGPDSERV RTWQRGAFHR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063218|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCAGGGGCA CCGCTGCGGG GTCACCCGGC TCAGGAGAGA GCAGGAGGGG CGGAGAAGCC 60
GAGCAGGTGG AGATTAGGTC AGCCTCAGAA CATTCTTGGA CCGCTCCAGT GAATATAAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063218|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR027267--AH/BAR-dom
IPR031160--F_BAR
IPR001060--FCH_dom
IPR028523--PACSIN3
IPR001452--SH3_domain
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00055--FCH
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019855--F:calcium channel inhibitor activity
GO:0008092--F:cytoskeletal protein binding
GO:0008289--F:lipid binding
GO:0006897--P:endocytosis
GO:0051926--P:negative regulation of calcium ion transport
GO:0045806--P:negative regulation of endocytosis
GO:0097320--P:plasma membrane tubulation
GO:0051044--P:positive regulation of membrane protein ectodomain proteolysis
KEGG mmu:80708
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001906 Ailuropoda melanoleuca 91.89 0.00e+00 629.00
IUUC-Apl-003211 Anas platyrhynchos 64.41 2.00e-178 618.00
IUUC-Aca-004256 Anolis carolinensis 65.05 5.00e-177 613.00
IUUC-Ame-011049 Astyanax mexicanus 62.16 1.00e-155 543.00
IUUC-Bta-013322 Bos taurus 89.74 0.00e+00 748.00
IUUC-Cja-018907 Callithrix jacchus 93.63 0.00e+00 787.00
IUUC-Cfa-021126 Canis familiaris 91.98 0.00e+00 772.00
IUUC-Cpo-021491 Cavia porcellus 94.10 0.00e+00 802.00
IUUC-Csa-023107 Chlorocebus sabaeus 94.34 0.00e+00 789.00
IUUC-Dre-027933 Danio rerio 61.50 6.00e-148 517.00
IUUC-Dno-029002 Dasypus novemcinctus 93.16 0.00e+00 749.00
IUUC-Eca-033824 Equus caballus 92.92 0.00e+00 783.00
IUUC-Eeu-035122 Erinaceus europaeus 81.87 6.00e-165 573.00
IUUC-Fca-036420 Felis catus 92.69 0.00e+00 786.00
IUUC-Fal-037277 Ficedula albicollis 63.68 1.00e-179 622.00
IUUC-Gga-040941 Gallus gallus 64.33 8.00e-178 616.00
IUUC-Gac-041374 Gasterosteus aculeatus 62.91 3.00e-138 484.00
IUUC-Ggo-045211 Gorilla gorilla 94.10 0.00e+00 787.00
IUUC-Hsa-046053 Homo sapiens 94.34 0.00e+00 789.00
IUUC-Itr-047939 Ictidomys tridecemlineatus 95.75 0.00e+00 809.00
IUUC-Loc-052808 Lepisosteus oculatus 62.87 8.00e-158 550.00
IUUC-Laf-054211 Loxodonta africana 92.92 0.00e+00 749.00
IUUC-Mcc-055044 Macaca mulatta 94.34 0.00e+00 789.00
IUUC-Mga-059216 Meleagris gallopavo 64.27 4.00e-178 617.00
IUUC-Mmr-061172 Microcebus murinus 94.34 0.00e+00 795.00
IUUC-Mdo-062600 Monodelphis domestica 86.56 0.00e+00 749.00
IUUC-Mpu-066819 Mustela putorius furo 92.19 0.00e+00 631.00
IUUC-Mlu-067597 Myotis lucifugus 89.10 0.00e+00 759.00
IUUC-Nle-069195 Nomascus leucogenys 94.34 0.00e+00 787.00
IUUC-Opr-071050 Ochotona princeps 93.41 0.00e+00 756.00
IUUC-Ont-071612 Oreochromis niloticus 57.14 2.00e-142 498.00
IUUC-Oan-073256 Ornithorhynchus anatinus 85.92 0.00e+00 720.00
IUUC-Ocu-074653 Oryctolagus cuniculus 95.28 0.00e+00 771.00
IUUC-Oga-089040 Otolemur garnettii 92.69 0.00e+00 790.00
IUUC-Oar-089918 Ovis aries 92.68 0.00e+00 764.00
IUUC-Ptr-091307 Pan troglodytes 94.34 0.00e+00 789.00
IUUC-Pan-092512 Papio anubis 94.34 0.00e+00 789.00
IUUC-Pfo-096881 Poecilia formosa 63.81 3.00e-155 541.00
IUUC-Pab-098620 Pongo abelii 94.34 0.00e+00 789.00
IUUC-Pva-102464 Pteropus vampyrus 90.80 0.00e+00 761.00
IUUC-Rno-106091 Rattus norvegicus 98.58 0.00e+00 828.00
IUUC-Sha-107474 Sarcophilus harrisii 87.03 0.00e+00 746.00
IUUC-Ssc-116128 Sus scrofa 92.69 0.00e+00 785.00
IUUC-Tru-118005 Takifugu rubripes 61.09 2.00e-141 495.00
IUUC-Tni-119851 Tetraodon nigroviridis 66.18 3.00e-140 491.00
IUUC-Ttr-129313 Tursiops truncatus 92.22 0.00e+00 784.00
IUUC-Vpa-130760 Vicugna pacos 93.99 3.00e-98 352.00
IUUC-Xtr-132697 Xenopus tropicalis 56.25 3.00e-138 484.00
Created Date 25-Jun-2017

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