iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091319

UUCD1 version

UUC-PaT-01076

Ensembl Protein ID

ENSPTRP00000008781.5

UniProt Accession

H2Q6D4; H2Q6D4_PANTR

Genbank Protein ID

JAA03009.1; JAA15443.1; JAA28668.1

Protein Name

Ubiquitin specific peptidase 15

Genbank Nucleotide ID

AACZ03086434; GABF01006702; GABD01004432

Gene Name

USP15

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000005163.5	ENSPTRT00000009494.5	ENSPTRP00000008781.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.30e-120	401.3	260	904
ULD/UDP/UBQ/UBQ_Other	2.30e-10	40.2	147	217

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl+NlgNtC+mNS++QcLsn+p+l+e++l+ k++e+ln +np ++ ge++ks+++l++++w++k ++v+pr+++++++++a++fsgy+
   Q: 260  CGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNdKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGYQ 348
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ ++kp+ +++++d   ++d+     a+e++ k+n+s+i+d+F+g +ks+++c+ec+++s++++pf++l
   Q: 349  QQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDAD--GRPDKvvaeeAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYL 435
           ******************************9999..5555555777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p+k+e+ +e                                                                            
   Q: 436  TLPLPMKKERTLEvylvrmdpltkpmqykvvvpkignildlctalsalsgipadkmivtdiynhrfhrifamdenlssimerddiyvfe 524
           *********9999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 525  ininrtedtehviipvclrekfrhssythhtgsslfgqpflmavprnntedklynllllrmcryvkisteteetegslhcckdqningn 613
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 614  gpngiheegspsemetdepddessqdqelpsenensqsedsvggdndsenglctedtckgqltghkkrlftfqfnnlgntdinyikddt 702
           ***************************************************************************************** PP
   S: 186  .......................................................slqdcLesftkeeelegenkyycekckkkqeaek 219
                                                                  +l+dc+e ft++e+l  e+ +yc++ck++q+a+k
   Q: 703  rhirfddrqlrldersflaldwdpdlkkryfdenaaedfekhesveykppkkpfvKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATK 791
           ***************************************************************************************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.W 306
           kl+l++lP+vL++hLkRfs+s+  ++r k+++ v+fp++ Ld+s+f+++p+ +   +++Y+Liav +H+G++++GHY+a++kn++++ W
   Q: 792  KLDLWSLPPVLVVHLKRFSYSR--YMRDKLDTLVDFPINdLDMSEFLINPNAG---PCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGkW 875
           ******************9977..6999*********************9988...8**************************65555* PP
   S: 307  llfdDskVtevkeeevleetgstaYvlfYkrr 338
           ++fdDs+V++ +e+++++   + aYvlfY+r+
   Q: 876  YYFDDSSVSTASEDQIVS---KAAYVLFYQRQ 904
           ******************...*********96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 12   eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk.....GkiL.eddktLadyglkdgstihllekksg 75
           + t++++++dt+ ++ ++i+k ++ip + + rL++k      ++L ++d t++d gl++g+++++++k+++
   Q: 147  VVTRRFSKADTIDTIEKEIRKIFNIPdEKETRLWNKymsntFEPLnKPDSTIQDAGLYQGQVLVIEQKNED 217
           77899*********************999*****998875544569*********************9986 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAEGGAADLD TQRSDIATLL KTSLRKGDTW YLVDSRWFKQ WKKYVGFDSW DKYQMGDQNV 60
YPGPIDNSGL LKDGDAQSLK EHLIDELDYI LLPTEGWNKL VSWYTLMEGQ EPIARKVVEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGAAGAAGA TGGCGGAAGG CGGAGCGGCG GATCTGGACA CCCAGCGGTC TGACATCGCG 60
ACGCTGCTCA AAACCTCGCT CCGGAAAGGG GACACCTGGT AAGAGACAGG GGTTGAGATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR013792--RNA3'P_cycl/enolpyr_Trfase_a/b
IPR028135--Ub_USP-typ
IPR029071--Ubiquitin-rel_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH
PF14533--USP7_C2

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0030509--P:BMP signaling pathway
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0060389--P:pathway-restricted SMAD protein phosphorylation
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ptr:452035

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000058	Aegilops tauschii	37.08	8.00e-120	424.00
IUUC-Aml-001852	Ailuropoda melanoleuca	95.62	0.00e+00	1863.00
IUUC-Apl-003249	Anas platyrhynchos	92.96	0.00e+00	1693.00
IUUC-Aca-004261	Anolis carolinensis	91.38	0.00e+00	1707.00
IUUC-Aly-005644	Arabidopsis lyrata	35.56	5.00e-140	491.00
IUUC-Ath-006782	Arabidopsis thaliana	35.25	2.00e-139	489.00
IUUC-Acl-008284	Aspergillus clavatus	33.66	2.00e-55	211.00
IUUC-Afl-008507	Aspergillus flavus	38.57	6.00e-55	209.00
IUUC-Afu-008878	Aspergillus fumigatus	33.54	7.00e-56	213.00
IUUC-Aor-009949	Aspergillus oryzae	38.29	7.00e-54	206.00
IUUC-Ate-010323	Aspergillus terreus	43.64	8.00e-54	206.00
IUUC-Ame-010757	Astyanax mexicanus	78.05	0.00e+00	1242.00
IUUC-Bgr-012277	Blumeria graminis	42.40	2.00e-63	238.00
IUUC-Bta-013128	Bos taurus	98.84	0.00e+00	1885.00
IUUC-Bci-013993	Botrytis cinerea	42.81	5.00e-64	240.00
IUUC-Bol-015570	Brassica oleracea	37.63	9.00e-155	540.00
IUUC-Bra-017029	Brassica rapa	36.57	4.00e-140	492.00
IUUC-Cja-019222	Callithrix jacchus	96.13	0.00e+00	1868.00
IUUC-Cfa-020035	Canis familiaris	95.62	0.00e+00	1862.00
IUUC-Cpo-022071	Cavia porcellus	95.01	0.00e+00	1774.00
IUUC-Csa-023882	Chlorocebus sabaeus	96.43	0.00e+00	1875.00
IUUC-Cin-025292	Ciona intestinalis	45.00	0.00e+00	752.00
IUUC-Cne-026852	Cryptococcus neoformans	46.45	3.00e-71	264.00
IUUC-Cme-027338	Cyanidioschyzon merolae	56.36	4.00e-68	253.00
IUUC-Dre-027869	Danio rerio	58.35	0.00e+00	1086.00
IUUC-Dno-029025	Dasypus novemcinctus	96.09	0.00e+00	1801.00
IUUC-Dor-030956	Dipodomys ordii	86.54	0.00e+00	1597.00
IUUC-Dse-031432	Dothistroma septosporum	40.43	3.00e-58	221.00
IUUC-Eca-034340	Equus caballus	95.90	0.00e+00	1810.00
IUUC-Eeu-034488	Erinaceus europaeus	84.60	0.00e+00	1232.00
IUUC-Fca-035552	Felis catus	98.95	0.00e+00	1880.00
IUUC-Fal-036618	Ficedula albicollis	92.86	0.00e+00	1687.00
IUUC-Gga-041146	Gallus gallus	91.75	0.00e+00	1731.00
IUUC-Gac-041679	Gasterosteus aculeatus	76.32	0.00e+00	1442.00
IUUC-Gma-043368	Glycine max	40.44	2.00e-120	426.00
IUUC-Ggo-045002	Gorilla gorilla	96.11	0.00e+00	1807.00
IUUC-Hsa-046052	Homo sapiens	96.33	0.00e+00	1873.00
IUUC-Hvu-047108	Hordeum vulgare	40.24	6.00e-123	434.00
IUUC-Itr-048306	Ictidomys tridecemlineatus	98.95	0.00e+00	1883.00
IUUC-Kpa-049332	Komagataella pastoris	34.15	8.00e-75	275.00
IUUC-Lch-050107	Latimeria chalumnae	84.44	0.00e+00	1707.00
IUUC-Lpe-051185	Leersia perrieri	36.96	8.00e-126	444.00
IUUC-Loc-052105	Lepisosteus oculatus	81.50	0.00e+00	1489.00
IUUC-Lma-052981	Leptosphaeria maculans	37.53	1.00e-67	252.00
IUUC-Laf-053645	Loxodonta africana	95.32	0.00e+00	1858.00
IUUC-Mcc-055586	Macaca mulatta	96.33	0.00e+00	1873.00
IUUC-Meu-056764	Macropus eugenii	90.15	0.00e+00	1004.00
IUUC-Mla-058848	Melampsora laricipopulina	40.56	3.00e-67	250.00
IUUC-Mga-060162	Meleagris gallopavo	92.06	0.00e+00	1736.00
IUUC-Mvi-060324	Microbotryum violaceum	32.11	6.00e-81	296.00
IUUC-Mmr-061105	Microcebus murinus	95.92	0.00e+00	1867.00
IUUC-Mdo-062107	Monodelphis domestica	93.79	0.00e+00	1806.00
IUUC-Mmu-063662	Mus musculus	94.29	0.00e+00	1843.00
IUUC-Mac-065239	Musa acuminata	33.30	8.00e-133	468.00
IUUC-Mpu-065868	Mustela putorius furo	93.71	0.00e+00	1853.00
IUUC-Mlu-068000	Myotis lucifugus	90.42	0.00e+00	1680.00
IUUC-Nfi-068330	Neosartorya fischeri	28.36	2.00e-58	221.00
IUUC-Nle-069874	Nomascus leucogenys	96.21	0.00e+00	1846.00
IUUC-Opr-071212	Ochotona princeps	90.15	0.00e+00	1747.00
IUUC-Ont-071834	Oreochromis niloticus	78.00	0.00e+00	1436.00
IUUC-Ocu-074573	Oryctolagus cuniculus	96.02	0.00e+00	1869.00
IUUC-Obr-076416	Oryza brachyantha	39.75	4.00e-119	422.00
IUUC-Ogl-077583	Oryza glaberrima	40.36	3.00e-128	452.00
IUUC-Oin-079300	Oryza indica	40.51	3.00e-129	456.00
IUUC-Ome-081271	Oryza meridionalis	35.79	3.00e-146	512.00
IUUC-Opu-083691	Oryza punctata	34.62	3.00e-143	502.00
IUUC-Oga-089022	Otolemur garnettii	98.42	0.00e+00	1878.00
IUUC-Oar-089767	Ovis aries	95.31	0.00e+00	1859.00
IUUC-Pan-091968	Papio anubis	96.43	0.00e+00	1875.00
IUUC-Psi-093849	Pelodiscus sinensis	91.39	0.00e+00	1684.00
IUUC-Pma-094533	Petromyzon marinus	60.58	0.00e+00	1121.00
IUUC-Pno-094890	Phaeosphaeria nodorum	37.39	2.00e-61	231.00
IUUC-Pfo-097110	Poecilia formosa	76.71	0.00e+00	1434.00
IUUC-Pab-098664	Pongo abelii	96.43	0.00e+00	1875.00
IUUC-Pop-099801	Populus trichocarpa	37.26	4.00e-152	531.00
IUUC-Pca-100359	Procavia capensis	86.34	0.00e+00	1103.00
IUUC-Ppe-101587	Prunus persica	37.30	3.00e-149	522.00
IUUC-Pva-102394	Pteropus vampyrus	93.88	0.00e+00	1817.00
IUUC-Pgr-103546	Puccinia graminis	29.52	7.00e-68	253.00
IUUC-Pte-104102	Pyrenophora teres	37.61	6.00e-59	223.00
IUUC-Pyt-104812	Pyrenophora triticirepentis	41.47	8.00e-58	219.00
IUUC-Rno-105383	Rattus norvegicus	98.21	0.00e+00	1878.00
IUUC-Sce-106170	Saccharomyces cerevisiae	36.97	1.00e-60	228.00
IUUC-Sha-107393	Sarcophilus harrisii	93.90	0.00e+00	1813.00
IUUC-Sja-107752	Schizosaccharomyces japonicus	36.03	8.00e-85	308.00
IUUC-Spo-108291	Schizosaccharomyces pombe	33.05	2.00e-77	284.00
IUUC-Ssl-108461	Sclerotinia sclerotiorum	30.56	1.00e-13	71.60
IUUC-Smo-109356	Selaginella moellendorffii	46.85	2.00e-79	290.00
IUUC-Sly-111726	Solanum lycopersicum	38.38	5.00e-94	338.00
IUUC-Sar-113498	Sorex araneus	94.90	0.00e+00	1849.00
IUUC-Sre-115130	Sporisorium reilianum	43.87	2.00e-77	284.00
IUUC-Ssc-115285	Sus scrofa	95.82	0.00e+00	1863.00
IUUC-Tgu-116529	Taeniopygia guttata	92.46	0.00e+00	1746.00
IUUC-Tru-118298	Takifugu rubripes	77.15	0.00e+00	1448.00
IUUC-Tsy-119117	Tarsius syrichta	89.79	0.00e+00	1157.00
IUUC-Tni-120093	Tetraodon nigroviridis	74.12	0.00e+00	1382.00
IUUC-Tre-121888	Trichoderma reesei	42.09	2.00e-62	235.00
IUUC-Tvi-122422	Trichoderma virens	39.57	6.00e-57	216.00
IUUC-Tur-126149	Triticum urartu	36.75	3.00e-106	380.00
IUUC-Tme-127062	Tuber melanosporum	31.65	1.00e-77	285.00
IUUC-Tbe-127672	Tupaia belangeri	86.82	0.00e+00	1218.00
IUUC-Ttr-128441	Tursiops truncatus	89.09	0.00e+00	1123.00
IUUC-Vpa-130469	Vicugna pacos	95.48	0.00e+00	1793.00
IUUC-Xtr-132729	Xenopus tropicalis	81.77	0.00e+00	1601.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence