iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040774

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ataxin-3; Machado-Joseph disease protein 1 homolog

Genbank Nucleotide ID

AF085247

Gene Name

ATXN3; MDJ1; MJD

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000010766.4	ENSGALT00000017509.3	ENSGALP00000017488.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UIM	3.90e-07	29.7	247	266
UBD/Alpha-Helix/UIM	3.7e-05	14.6	227	245

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeees 20
           dE+++L++A++lS+q  ++s
   Q: 247  DEEADLRRAIQLSMQGSRQS 266
           7**************98875 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +++e +q+AlalS+qE ++
   Q: 227  EDEENFQRALALSRQEIDM 245
           69**************886 PP

Organism

Gallus gallus

Functional Description
(View)

Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity).

Protein Sequence
(Fasta)

MESIFHERQE GSLCAQHCLN NLLQGEYFSP VELSSIAQQL DEEERMRMAE GGVSSEEYRT 60
FLQQPSVNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLGIDPINEK SFICNYKEHW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCCGTGCC GTTGACAATA AACATGGAGT CGATCTTCCA CGAGCGGGTG AGTGAGCGGT 60
GGTGGGGAGG TCGGGTGTAT TCGATGAGGC GTCTCGCAGG TGCAGCGCCT TCGGTCGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway

Interpro

IPR033865--Ataxin-3
IPR006155--Josephin
IPR009068--S15_NS1_RNA-bd
IPR003903--UIM_dom

PROSITE

PS50957--JOSEPHIN
PS50330--UIM

Pfam

PF02099--Josephin
PF02809--UIM

SMART

SM01246--Josephin
SM00726--UIM

Gene Ontology

GO:0005759--C:mitochondrial matrix
GO:0031966--C:mitochondrial membrane
GO:0042405--C:nuclear inclusion body
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0034605--P:cellular response to heat
GO:0071218--P:cellular response to misfolded protein
GO:0035640--P:exploration behavior
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0010810--P:regulation of cell-substrate adhesion
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

gga:378424

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002015	Ailuropoda melanoleuca	77.09	6.00e-151	526.00
IUUC-Atr-002735	Amborella trichopoda	50.00	1.00e-06	43.50
IUUC-Apl-003210	Anas platyrhynchos	93.52	0.00e+00	639.00
IUUC-Aca-005171	Anolis carolinensis	75.77	1.00e-135	475.00
IUUC-Aly-005625	Arabidopsis lyrata	44.64	2.00e-40	159.00
IUUC-Ath-007088	Arabidopsis thaliana	44.64	1.00e-40	159.00
IUUC-Ame-010715	Astyanax mexicanus	70.79	2.00e-123	434.00
IUUC-Bta-013538	Bos taurus	71.28	1.00e-149	522.00
IUUC-Bdi-015000	Brachypodium distachyon	42.01	2.00e-35	142.00
IUUC-Bol-015894	Brassica oleracea	43.45	4.00e-40	159.00
IUUC-Bra-018020	Brassica rapa	44.31	9.00e-41	160.00
IUUC-Cel-018121	Caenorhabditis elegans	35.37	6.00e-41	160.00
IUUC-Cja-018840	Callithrix jacchus	82.18	5.00e-144	503.00
IUUC-Cfa-021035	Canis familiaris	76.49	9.00e-156	542.00
IUUC-Cpo-021776	Cavia porcellus	71.81	5.00e-147	513.00
IUUC-Csa-023257	Chlorocebus sabaeus	59.46	2.00e-119	421.00
IUUC-Cho-024878	Choloepus hoffmanni	76.04	1.00e-149	522.00
IUUC-Cgl-026754	Colletotrichum gloeosporioides	33.96	1.50e+00	28.50
IUUC-Cme-027158	Cyanidioschyzon merolae	30.69	2.00e-13	68.60
IUUC-Dre-027506	Danio rerio	67.05	3.00e-91	327.00
IUUC-Dno-029172	Dasypus novemcinctus	74.60	2.00e-152	531.00
IUUC-Dor-030900	Dipodomys ordii	86.97	2.00e-133	468.00
IUUC-Ete-033000	Echinops telfairi	51.31	1.00e-72	266.00
IUUC-Eca-034338	Equus caballus	75.55	4.00e-149	520.00
IUUC-Eeu-034585	Erinaceus europaeus	95.24	2.00e-55	208.00
IUUC-Fca-035441	Felis catus	64.94	5.00e-50	189.00
IUUC-Fal-037525	Ficedula albicollis	90.61	2.00e-169	587.00
IUUC-Gmo-039718	Gadus morhua	70.30	6.00e-112	396.00
IUUC-Gac-041671	Gasterosteus aculeatus	69.97	8.00e-107	379.00
IUUC-Gma-042801	Glycine max	41.32	9.00e-37	147.00
IUUC-Ggo-044759	Gorilla gorilla	71.62	2.00e-117	415.00
IUUC-Hsa-046591	Homo sapiens	82.45	2.00e-143	501.00
IUUC-Hvu-047492	Hordeum vulgare	42.60	2.00e-33	136.00
IUUC-Itr-048851	Ictidomys tridecemlineatus	66.10	3.00e-100	357.00
IUUC-Lch-049519	Latimeria chalumnae	72.73	7.00e-117	412.00
IUUC-Lpe-050819	Leersia perrieri	43.27	1.00e-35	143.00
IUUC-Loc-051816	Lepisosteus oculatus	66.01	8.00e-130	456.00
IUUC-Laf-053784	Loxodonta africana	76.84	2.00e-154	538.00
IUUC-Mcc-055283	Macaca mulatta	76.41	2.00e-154	537.00
IUUC-Meu-056589	Macropus eugenii	69.89	3.00e-142	497.00
IUUC-Mtr-058233	Medicago truncatula	35.56	7.00e-37	147.00
IUUC-Mla-059013	Melampsora laricipopulina	38.58	2.00e-30	125.00
IUUC-Mga-059301	Meleagris gallopavo	97.80	0.00e+00	717.00
IUUC-Mmr-061038	Microcebus murinus	75.33	1.00e-155	542.00
IUUC-Mdo-062927	Monodelphis domestica	81.25	3.00e-149	521.00
IUUC-Mmu-063600	Mus musculus	74.93	3.00e-142	497.00
IUUC-Mpu-065897	Mustela putorius furo	82.37	2.00e-138	484.00
IUUC-Mlu-067543	Myotis lucifugus	80.60	3.00e-138	484.00
IUUC-Nle-069847	Nomascus leucogenys	70.89	3.00e-139	488.00
IUUC-Opr-070550	Ochotona princeps	68.14	1.00e-127	449.00
IUUC-Ont-071723	Oreochromis niloticus	65.14	1.00e-113	402.00
IUUC-Oan-073569	Ornithorhynchus anatinus	74.80	4.00e-161	560.00
IUUC-Ocu-074632	Oryctolagus cuniculus	76.67	4.00e-152	530.00
IUUC-Oba-075288	Oryza barthii	43.27	2.00e-37	149.00
IUUC-Obr-076050	Oryza brachyantha	42.69	2.00e-33	136.00
IUUC-Ogl-077174	Oryza glaberrima	43.27	2.00e-37	149.00
IUUC-Ogu-078006	Oryza glumaepatula	43.27	2.00e-37	149.00
IUUC-Oin-079278	Oryza indica	40.88	4.00e-35	141.00
IUUC-Olo-080941	Oryza longistaminata	43.27	2.00e-37	149.00
IUUC-Ome-081172	Oryza meridionalis	43.27	2.00e-37	149.00
IUUC-Oni-082239	Oryza nivara	43.27	2.00e-37	149.00
IUUC-Opu-083939	Oryza punctata	42.69	7.00e-37	147.00
IUUC-Oru-084393	Oryza rufipogon	43.27	2.00e-37	149.00
IUUC-Osa-086080	Oryza sativa	43.27	1.00e-37	149.00
IUUC-Ola-087566	Oryzias latipes	69.64	6.00e-109	386.00
IUUC-Oga-088617	Otolemur garnettii	65.68	2.00e-104	371.00
IUUC-Oar-090052	Ovis aries	70.98	4.00e-149	520.00
IUUC-Ptr-091435	Pan troglodytes	75.94	4.00e-155	540.00
IUUC-Pan-092742	Papio anubis	60.33	3.00e-119	421.00
IUUC-Psi-093313	Pelodiscus sinensis	91.79	2.00e-140	491.00
IUUC-Pma-094374	Petromyzon marinus	60.30	1.00e-83	302.00
IUUC-Pno-095003	Phaeosphaeria nodorum	32.18	2.50e-01	30.80
IUUC-Ppa-095601	Physcomitrella patens	44.64	2.00e-44	172.00
IUUC-Pfo-097327	Poecilia formosa	68.77	3.00e-111	394.00
IUUC-Pab-098611	Pongo abelii	72.98	2.00e-123	435.00
IUUC-Pca-101022	Procavia capensis	93.75	4.00e-61	228.00
IUUC-Ppe-101545	Prunus persica	42.86	7.00e-38	150.00
IUUC-Pva-102844	Pteropus vampyrus	75.34	1.00e-153	535.00
IUUC-Rno-104896	Rattus norvegicus	73.30	2.00e-147	514.00
IUUC-Sha-107106	Sarcophilus harrisii	78.63	3.00e-167	580.00
IUUC-Sit-110477	Setaria italica	43.86	3.00e-37	148.00
IUUC-Sly-111416	Solanum lycopersicum	39.13	1.00e-17	82.40
IUUC-Stu-112227	Solanum tuberosum	40.86	2.00e-19	88.60
IUUC-Sar-113534	Sorex araneus	70.88	9.00e-134	469.00
IUUC-Sbi-114751	Sorghum bicolor	42.77	2.00e-35	142.00
IUUC-Ssc-115274	Sus scrofa	77.53	4.00e-156	543.00
IUUC-Tgu-117426	Taeniopygia guttata	90.70	3.00e-174	603.00
IUUC-Tru-118059	Takifugu rubripes	70.17	2.00e-107	381.00
IUUC-Tsy-119448	Tarsius syrichta	78.22	6.00e-82	297.00
IUUC-Tni-120681	Tetraodon nigroviridis	88.37	4.00e-60	222.00
IUUC-Tca-121442	Theobroma cacao	35.05	1.00e-41	163.00
IUUC-Tae-123969	Triticum aestivum	42.11	6.00e-32	130.00
IUUC-Tbe-127638	Tupaia belangeri	71.55	4.00e-134	470.00
IUUC-Ttr-129288	Tursiops truncatus	67.39	2.00e-130	458.00
IUUC-Uma-129359	Ustilago maydis	40.21	5.00e-35	142.00
IUUC-Vpa-130788	Vicugna pacos	74.80	1.00e-149	521.00
IUUC-Vvi-131227	Vitis vinifera	43.11	4.00e-36	144.00
IUUC-Xtr-132147	Xenopus tropicalis	70.34	7.00e-134	469.00
IUUC-Xma-133144	Xiphophorus maculatus	67.77	5.00e-109	387.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence