iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132513

UUCD1 version

UUC-XeT-00040

Ensembl Protein ID

ENSXETP00000023594.2

UniProt Accession

B2WUN8; B2WUN8_XENTR

Genbank Protein ID

ABQ53620.1; OCA19891.1

Protein Name

Suppressor of cytokine signaling 6

Genbank Nucleotide ID

AAMC01123214; KV460363

Gene Name

socs6; SOCS6; XENTR_v90027150mg

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000010791.2	ENSXETT00000023594.2	ENSXETP00000023594.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.70e-17	62.1	486	533

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
            ++ +++ ++rSLq+LCR++Ir++++++ +   +kLPLP+++kdYL++++y
   Q: 486  TNPVSRFMQVRSLQYLCRFVIRQYTRIDLI---QKLPLPNKMKDYLQEKHY 533
           5788999********************888...***************997 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MKKISLKTFR KSFNLNKGKE ENDFVMVKQP SMTNNFGKDD SLFGSCYGRD LTGCEISSED 60
EKNGKNRPKS ESLMGTLKRR LSAKQKQKGK SSTSGNCAEE DTFSSSSAPI TFKDVRAQRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCGGCAGG AGCCAAGGAG CTGGGCATTA ACGGCGTTGT GGGACGTTTA AGCTGCGATC 60
CGGGACTGCG GGTTGCGTTA AGAACATCGG CACTGTTGGG CGGTATGGAA TTGTACTTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028421--SOCS6
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001911	Ailuropoda melanoleuca	82.99	0.00e+00	840.00
IUUC-Atr-002940	Amborella trichopoda	27.59	6.30e-02	31.60
IUUC-Apl-004035	Anas platyrhynchos	86.73	0.00e+00	855.00
IUUC-Aca-004782	Anolis carolinensis	83.40	0.00e+00	816.00
IUUC-Afl-008492	Aspergillus flavus	23.02	2.80e-01	29.60
IUUC-Ame-011790	Astyanax mexicanus	66.85	5.00e-180	623.00
IUUC-Bta-012579	Bos taurus	89.86	2.00e-102	365.00
IUUC-Cja-019528	Callithrix jacchus	83.36	0.00e+00	884.00
IUUC-Cfa-020678	Canis familiaris	83.55	0.00e+00	862.00
IUUC-Cpo-021947	Cavia porcellus	83.18	0.00e+00	885.00
IUUC-Csa-023935	Chlorocebus sabaeus	82.24	0.00e+00	848.00
IUUC-Cho-024477	Choloepus hoffmanni	81.12	0.00e+00	853.00
IUUC-Cin-025413	Ciona intestinalis	66.47	5.00e-64	238.00
IUUC-Csv-026247	Ciona savignyi	66.87	1.00e-63	236.00
IUUC-Cne-026906	Cryptococcus neoformans	23.96	1.20e+00	28.10
IUUC-Dre-027636	Danio rerio	67.16	0.00e+00	633.00
IUUC-Dno-029048	Dasypus novemcinctus	82.43	0.00e+00	848.00
IUUC-Dor-030401	Dipodomys ordii	79.66	0.00e+00	811.00
IUUC-Ete-033116	Echinops telfairi	44.52	7.00e-50	190.00
IUUC-Eca-033825	Equus caballus	82.06	0.00e+00	815.00
IUUC-Fca-036253	Felis catus	80.93	0.00e+00	770.00
IUUC-Fal-037614	Ficedula albicollis	85.98	0.00e+00	850.00
IUUC-Fox-037898	Fusarium oxysporum	29.27	3.00e-03	35.40
IUUC-Gmo-038928	Gadus morhua	68.07	0.00e+00	679.00
IUUC-Gga-040177	Gallus gallus	87.10	0.00e+00	858.00
IUUC-Gac-042263	Gasterosteus aculeatus	70.06	0.00e+00	707.00
IUUC-Ggo-045288	Gorilla gorilla	82.43	0.00e+00	855.00
IUUC-Hsa-046409	Homo sapiens	82.62	0.00e+00	854.00
IUUC-Itr-048996	Ictidomys tridecemlineatus	81.31	0.00e+00	817.00
IUUC-Lch-050354	Latimeria chalumnae	80.22	0.00e+00	833.00
IUUC-Loc-052319	Lepisosteus oculatus	76.26	0.00e+00	781.00
IUUC-Laf-054070	Loxodonta africana	80.19	0.00e+00	807.00
IUUC-Mcc-055045	Macaca mulatta	82.24	0.00e+00	847.00
IUUC-Meu-055917	Macropus eugenii	86.54	0.00e+00	915.00
IUUC-Mga-059273	Meleagris gallopavo	86.36	0.00e+00	848.00
IUUC-Mmr-061597	Microcebus murinus	82.99	0.00e+00	853.00
IUUC-Mdo-062492	Monodelphis domestica	61.99	3.00e-105	374.00
IUUC-Mmu-063374	Mus musculus	73.93	0.00e+00	744.00
IUUC-Mpu-065967	Mustela putorius furo	78.13	0.00e+00	804.00
IUUC-Mlu-067532	Myotis lucifugus	79.44	0.00e+00	813.00
IUUC-Nle-069373	Nomascus leucogenys	82.62	0.00e+00	852.00
IUUC-Opr-070873	Ochotona princeps	79.44	0.00e+00	848.00
IUUC-Ont-072498	Oreochromis niloticus	71.03	0.00e+00	740.00
IUUC-Oan-072943	Ornithorhynchus anatinus	68.33	8.00e-97	346.00
IUUC-Ocu-073870	Oryctolagus cuniculus	82.06	0.00e+00	842.00
IUUC-Ola-086866	Oryzias latipes	88.94	2.00e-106	377.00
IUUC-Oga-089057	Otolemur garnettii	79.44	0.00e+00	811.00
IUUC-Oar-089841	Ovis aries	54.68	2.00e-151	528.00
IUUC-Ptr-091054	Pan troglodytes	82.62	0.00e+00	853.00
IUUC-Pma-094253	Petromyzon marinus	42.75	2.00e-96	345.00
IUUC-Pfo-097179	Poecilia formosa	64.88	3.00e-180	624.00
IUUC-Pab-097702	Pongo abelii	82.62	0.00e+00	853.00
IUUC-Pca-100671	Procavia capensis	74.05	3.00e-113	402.00
IUUC-Rno-106044	Rattus norvegicus	71.87	0.00e+00	734.00
IUUC-Sha-107139	Sarcophilus harrisii	85.54	0.00e+00	833.00
IUUC-Smo-108823	Selaginella moellendorffii	33.96	5.60e-02	31.20
IUUC-Sly-111748	Solanum lycopersicum	46.15	3.00e-01	29.60
IUUC-Ssc-115343	Sus scrofa	80.75	0.00e+00	841.00
IUUC-Tgu-117061	Taeniopygia guttata	86.36	0.00e+00	854.00
IUUC-Tni-119829	Tetraodon nigroviridis	67.28	0.00e+00	656.00
IUUC-Tae-123723	Triticum aestivum	41.18	7.20e-01	29.30
IUUC-Ttr-129148	Tursiops truncatus	80.00	0.00e+00	800.00
IUUC-Vpa-130780	Vicugna pacos	78.28	0.00e+00	775.00
IUUC-Xma-133904	Xiphophorus maculatus	68.76	0.00e+00	679.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence