iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Spo-108024

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase ptr1; HECT-type E3 ubiquitin transferase ptr1; Poly(A)+ RNA transport protein 1

Genbank Nucleotide ID

CU329670

Gene Name

ptr1; SPAC19D5.04

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC19D5.04	SPAC19D5.04.1	SPAC19D5.04.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
HINT
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.40e-121	402.1	2898	3226

Active Site

Position(s)	Description	Evidence
3194	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksf 96
           ++l+++f++Eeg+d+gGvtre+l+ l+++++npd+ lfl   +d +t++pn+ds + np+hl++F+f Gr++gkal+dgrlld+++s+++
   Q: 2898 SKLNIHFRDEEGVDAGGVTREWLQVLARQMFNPDYALFLPVTGDATTFHPNRDSSV-NPDHLSFFKFTGRIIGKALYDGRLLDCHFSRAV 2986
           6899***************************************************9.89******************************* PP
   S: 97   yklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegi 186
           yk++l++++s++d+e++dp++yksl ++++n   di+++ ++ +f v+++++ge ++++L+p+G+nipVt+ Nk++Yv+++v+y+l+e++
   Q: 2987 YKHMLHRSVSVKDIESLDPDYYKSLVWMLNN---DITDI-ITEEFAVEKDVFGEKTVVDLIPNGRNIPVTELNKQNYVNRMVDYKLRESV 3072
           *****************************99...99999.999*********************************************** PP
   S: 187  keqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPl 276
           k q++++ +Gf+++ip +l+++F+e+elelli+G +eid++d+k++t+y +gy+ +sp++qwFw+++++f++eer+++LqF+Tg+s++Pl
   Q: 3073 KDQLKSLLDGFSDIIPSHLIQIFNEQELELLISGLPEIDIDDWKNNTEY-HGYNVSSPQVQWFWRAVRSFDEEERAKLLQFATGTSKVPL 3161
           *************************************************.88************************************** PP
   S: 277  gGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +Gf+el+     ++f i+k ++s +rlP+s+TCfn+L+LPeY+++e+l+++Ll+Ai+e+ +gF++
   Q: 3162 NGFKELEgmsgFQRFNIHKsYGSLNRLPQSHTCFNQLDLPEYDTYEQLRSMLLTAINEGsEGFGF 3226
           *********99889*****88888***************************************86 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Probable ubiquitin ligase protein involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Probably participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins such as rae1.

Protein Sequence
(Fasta)

MRITKSPPKN QYSQPPPRVA EFIRQAQNEE VTSDLGLVSL CSEFRKNDWP YPRGDLYSWV 60
PVLNRFDAIL ERIVEHYSLK DKVQTKPFDS DTLSILLEIL SFSAHLLSHC ANRSIYNSTV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTTACCAA ACATTCAGCT GGGTCTATTT CCCTTCTGTT CGTTGGTACA ATTCATTAGA 60
ACATAATAAA TTTGGCATTT TTCTCAAGGT GGGTATTTAA CTATATTTCG AGATTTTGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0509--mRNA transport
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0006406--P:mRNA export from nucleus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

spo:SPAC19D5.04

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	37.82	3.00e-108	386.00
IUUC-Aml-001684	Ailuropoda melanoleuca	52.19	8.00e-130	458.00
IUUC-Atr-002582	Amborella trichopoda	49.53	6.00e-132	464.00
IUUC-Apl-003729	Anas platyrhynchos	51.76	4.00e-96	342.00
IUUC-Aca-005263	Anolis carolinensis	46.02	3.00e-131	463.00
IUUC-Aly-006157	Arabidopsis lyrata	42.91	6.00e-135	474.00
IUUC-Ath-007160	Arabidopsis thaliana	34.01	1.00e-136	480.00
IUUC-Ago-008005	Ashbya gossypii	40.20	0.00e+00	730.00
IUUC-Acl-008254	Aspergillus clavatus	59.91	0.00e+00	791.00
IUUC-Afl-008712	Aspergillus flavus	44.81	0.00e+00	883.00
IUUC-Afu-009022	Aspergillus fumigatus	58.92	0.00e+00	789.00
IUUC-Ani-009412	Aspergillus nidulans	48.24	0.00e+00	852.00
IUUC-Ang-009771	Aspergillus niger	56.06	0.00e+00	786.00
IUUC-Aor-010186	Aspergillus oryzae	44.14	0.00e+00	818.00
IUUC-Ate-010253	Aspergillus terreus	59.56	0.00e+00	786.00
IUUC-Ame-011067	Astyanax mexicanus	52.18	7.00e-129	455.00
IUUC-Bgr-012043	Blumeria graminis	48.89	0.00e+00	852.00
IUUC-Bta-012813	Bos taurus	52.19	1.00e-129	457.00
IUUC-Bci-013995	Botrytis cinerea	57.67	0.00e+00	769.00
IUUC-Bdi-014884	Brachypodium distachyon	49.30	1.00e-131	464.00
IUUC-Bol-016533	Brassica oleracea	55.64	2.00e-93	332.00
IUUC-Bra-016637	Brassica rapa	31.67	1.00e-133	471.00
IUUC-Cel-018179	Caenorhabditis elegans	48.47	2.00e-120	426.00
IUUC-Cja-018741	Callithrix jacchus	52.63	3.00e-129	456.00
IUUC-Cfa-020083	Canis familiaris	52.19	1.00e-129	457.00
IUUC-Cpo-021923	Cavia porcellus	44.06	5.00e-94	339.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	50.59	4.00e-134	469.00
IUUC-Csa-023853	Chlorocebus sabaeus	52.19	1.00e-129	457.00
IUUC-Cho-024718	Choloepus hoffmanni	54.52	1.00e-120	427.00
IUUC-Cin-025627	Ciona intestinalis	51.18	1.00e-125	444.00
IUUC-Csv-025872	Ciona savignyi	51.18	2.00e-125	440.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	43.14	0.00e+00	832.00
IUUC-Cne-027095	Cryptococcus neoformans	34.76	7.00e-175	607.00
IUUC-Cme-027267	Cyanidioschyzon merolae	50.48	3.00e-119	421.00
IUUC-Dre-028525	Danio rerio	49.75	1.00e-112	401.00
IUUC-Dno-029680	Dasypus novemcinctus	52.19	7.00e-130	458.00
IUUC-Dor-030902	Dipodomys ordii	47.92	3.00e-112	400.00
IUUC-Dse-031197	Dothistroma septosporum	46.17	0.00e+00	804.00
IUUC-Dme-032122	Drosophila melanogaster	50.81	9.00e-126	445.00
IUUC-Ete-032966	Echinops telfairi	40.05	2.00e-91	328.00
IUUC-Eca-033915	Equus caballus	51.39	4.00e-128	452.00
IUUC-Eeu-034963	Erinaceus europaeus	51.84	1.00e-127	451.00
IUUC-Fca-035824	Felis catus	52.19	9.00e-130	457.00
IUUC-Fox-037756	Fusarium oxysporum	44.36	0.00e+00	864.00
IUUC-Fso-038464	Fusarium solani	45.56	0.00e+00	876.00
IUUC-Gmo-039073	Gadus morhua	52.19	7.00e-130	458.00
IUUC-Ggr-039946	Gaeumannomyces graminis	47.70	0.00e+00	845.00
IUUC-Gga-040309	Gallus gallus	56.35	2.00e-103	367.00
IUUC-Gac-042430	Gasterosteus aculeatus	52.19	8.00e-130	458.00
IUUC-Gma-044216	Glycine max	38.96	3.00e-133	469.00
IUUC-Hsa-046879	Homo sapiens	52.19	1.00e-129	457.00
IUUC-Hvu-047697	Hordeum vulgare	41.92	3.00e-133	469.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	52.19	5.00e-130	457.00
IUUC-Kpa-049228	Komagataella pastoris	46.07	0.00e+00	811.00
IUUC-Lch-050252	Latimeria chalumnae	52.30	4.00e-129	456.00
IUUC-Lpe-051550	Leersia perrieri	47.10	6.00e-135	475.00
IUUC-Loc-052472	Lepisosteus oculatus	52.66	7.00e-131	461.00
IUUC-Lma-053159	Leptosphaeria maculans	47.19	0.00e+00	852.00
IUUC-Laf-054154	Loxodonta africana	52.19	1.00e-129	457.00
IUUC-Mcc-055085	Macaca mulatta	52.19	9.00e-130	458.00
IUUC-Mor-057201	Magnaporthe oryzae	45.85	0.00e+00	835.00
IUUC-Mpo-057597	Magnaporthe poae	57.99	0.00e+00	763.00
IUUC-Mtr-058128	Medicago truncatula	50.94	4.00e-131	462.00
IUUC-Mla-058888	Melampsora laricipopulina	57.04	2.00e-145	506.00
IUUC-Mvi-060320	Microbotryum violaceum	41.95	0.00e+00	660.00
IUUC-Mmr-060820	Microcebus murinus	52.19	8.00e-130	458.00
IUUC-Mdo-062930	Monodelphis domestica	46.02	6.00e-131	462.00
IUUC-Mmu-063601	Mus musculus	52.19	1.00e-129	457.00
IUUC-Mac-065229	Musa acuminata	42.81	5.00e-133	468.00
IUUC-Mpu-066653	Mustela putorius furo	52.19	8.00e-130	458.00
IUUC-Mlu-067418	Myotis lucifugus	45.30	2.00e-130	460.00
IUUC-Nfi-068278	Neosartorya fischeri	58.92	0.00e+00	790.00
IUUC-Ncr-068813	Neurospora crassa	59.33	0.00e+00	785.00
IUUC-Nle-069418	Nomascus leucogenys	52.19	1.00e-129	457.00
IUUC-Ont-071300	Oreochromis niloticus	52.19	8.00e-130	458.00
IUUC-Oan-073046	Ornithorhynchus anatinus	46.04	3.00e-130	459.00
IUUC-Ocu-074178	Oryctolagus cuniculus	52.19	6.00e-130	458.00
IUUC-Oba-075757	Oryza barthii	42.02	2.00e-135	476.00
IUUC-Obr-076553	Oryza brachyantha	42.71	5.00e-135	475.00
IUUC-Ogl-077520	Oryza glaberrima	42.02	2.00e-135	476.00
IUUC-Ogu-078278	Oryza glumaepatula	42.02	3.00e-135	476.00
IUUC-Oin-079767	Oryza indica	42.02	2.00e-135	476.00
IUUC-Olo-080380	Oryza longistaminata	41.74	2.00e-133	470.00
IUUC-Ome-081925	Oryza meridionalis	41.91	4.00e-134	472.00
IUUC-Oni-082619	Oryza nivara	42.02	2.00e-135	476.00
IUUC-Opu-083684	Oryza punctata	41.74	1.00e-133	470.00
IUUC-Oru-084501	Oryza rufipogon	42.02	2.00e-135	476.00
IUUC-Osa-086251	Oryza sativa	42.02	3.00e-135	473.00
IUUC-Olu-087813	Ostreococcus lucimarinus	46.44	4.00e-113	399.00
IUUC-Oga-088903	Otolemur garnettii	52.19	1.00e-129	457.00
IUUC-Oar-090210	Ovis aries	52.19	1.00e-129	457.00
IUUC-Pan-092368	Papio anubis	50.63	3.00e-114	406.00
IUUC-Pno-094871	Phaeosphaeria nodorum	47.21	0.00e+00	837.00
IUUC-Ppa-095834	Physcomitrella patens	51.04	3.00e-133	469.00
IUUC-Pfo-096232	Poecilia formosa	52.19	6.00e-130	458.00
IUUC-Pab-098583	Pongo abelii	52.19	1.00e-129	457.00
IUUC-Pop-099613	Populus trichocarpa	41.54	2.00e-129	456.00
IUUC-Ppe-102109	Prunus persica	34.36	1.00e-129	457.00
IUUC-Pva-102116	Pteropus vampyrus	49.19	1.00e-117	417.00
IUUC-Pgr-103465	Puccinia graminis	46.97	7.00e-176	611.00
IUUC-Ptt-103813	Puccinia triticina	44.32	1.00e-159	557.00
IUUC-Pte-104018	Pyrenophora teres	42.58	0.00e+00	796.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	46.88	0.00e+00	837.00
IUUC-Sce-106449	Saccharomyces cerevisiae	41.05	0.00e+00	775.00
IUUC-Sha-106961	Sarcophilus harrisii	46.02	7.00e-131	461.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	50.76	0.00e+00	2936.00
IUUC-Smo-109640	Selaginella moellendorffii	50.94	2.00e-134	473.00
IUUC-Sit-110598	Setaria italica	42.39	7.00e-136	478.00
IUUC-Sly-111285	Solanum lycopersicum	43.30	2.00e-133	469.00
IUUC-Sar-113291	Sorex araneus	52.66	1.00e-124	441.00
IUUC-Sbi-114042	Sorghum bicolor	42.96	3.00e-137	482.00
IUUC-Sre-114958	Sporisorium reilianum	56.97	2.00e-174	603.00
IUUC-Ssc-115754	Sus scrofa	52.19	9.00e-130	457.00
IUUC-Tru-118570	Takifugu rubripes	52.19	7.00e-130	458.00
IUUC-Tsy-119407	Tarsius syrichta	42.67	4.00e-88	317.00
IUUC-Tni-120836	Tetraodon nigroviridis	51.04	7.00e-125	441.00
IUUC-Tca-121479	Theobroma cacao	43.75	3.00e-134	473.00
IUUC-Tre-121909	Trichoderma reesei	45.45	0.00e+00	878.00
IUUC-Tvi-122370	Trichoderma virens	44.93	0.00e+00	866.00
IUUC-Tae-125214	Triticum aestivum	39.42	8.00e-129	453.00
IUUC-Tme-127172	Tuber melanosporum	60.41	0.00e+00	806.00
IUUC-Ttr-129253	Tursiops truncatus	52.19	2.00e-129	457.00
IUUC-Uma-129355	Ustilago maydis	57.14	1.00e-177	613.00
IUUC-Vda-129886	Verticillium dahliae	56.97	0.00e+00	747.00
IUUC-Vpa-130708	Vicugna pacos	52.19	2.00e-129	457.00
IUUC-Vvi-131078	Vitis vinifera	43.50	7.00e-132	464.00
IUUC-Xtr-132123	Xenopus tropicalis	49.42	3.00e-118	419.00
IUUC-Xma-133869	Xiphophorus maculatus	52.19	6.00e-130	458.00
IUUC-Yli-134657	Yarrowia lipolytica	43.74	0.00e+00	832.00
IUUC-Zma-135570	Zea mays	42.54	8.00e-135	474.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence