iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-049946

Ensembl Protein ID

ENSLACP00000012775.1

UniProt Accession

H3AT04; H3AT04_LATCH

Genbank Protein ID

ENSLACP00000012775

Protein Name

Presenilin

Genbank Nucleotide ID

AFYH01112219

Gene Name

PSEN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000011253.1	ENSLACT00000012869.1	ENSLACP00000012775.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.10e-08	33.7	273	309

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnn 38
           +eta+e++++iFP+l+ys+++v+L+ +++ +++a  +
   Q: 273  VETAQERNEPIFPALIYSSTMVWLVGMADPDPEARRK 309
           89*************************9988877666 PP

Organism

Latimeria chalumnae

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MTELSASLPV YQQGQLTEDF PDSRQTNSKK KSLFFQNESG ERRPNESRNA ESNGEPQAAS 60
QRVVVSDEEE DEELTLKYGA KHVIMLFVPV TLCMVVVVAT IKSVSFYTKK NGQLIYTPFS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGACTTCCT ACCAATCGGG CCTGCTGGAA GGGAGGAGCG GCTGGTGTTG TTGGAAAGGA 60
GCTGAGCTTC TAAACCTGAG TTTAAGCCCT CAGAGGAGAG GGTCGGAGGC TGGGGTAACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01073--PRESENILIN1

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001648	Ailuropoda melanoleuca	69.95	6.00e-118	416.00
IUUC-Atr-003039	Amborella trichopoda	32.87	2.00e-20	93.60
IUUC-Apl-003727	Anas platyrhynchos	69.64	9.00e-154	536.00
IUUC-Aca-004582	Anolis carolinensis	66.74	2.00e-154	538.00
IUUC-Ame-011500	Astyanax mexicanus	69.18	2.00e-132	465.00
IUUC-Bta-013026	Bos taurus	64.51	2.00e-142	499.00
IUUC-Bdi-014196	Brachypodium distachyon	29.73	1.00e-16	81.30
IUUC-Bol-015841	Brassica oleracea	39.25	3.00e-12	66.20
IUUC-Bra-017580	Brassica rapa	38.32	3.00e-12	66.20
IUUC-Cel-018553	Caenorhabditis elegans	46.80	7.00e-79	287.00
IUUC-Cja-019994	Callithrix jacchus	71.22	9.00e-143	499.00
IUUC-Cfa-020074	Canis familiaris	67.80	3.00e-148	518.00
IUUC-Cpo-022237	Cavia porcellus	68.89	1.00e-143	502.00
IUUC-Csa-023537	Chlorocebus sabaeus	66.60	8.00e-147	513.00
IUUC-Cho-024735	Choloepus hoffmanni	58.17	1.00e-130	459.00
IUUC-Cin-025780	Ciona intestinalis	56.47	3.00e-105	374.00
IUUC-Dre-028689	Danio rerio	67.59	2.00e-128	452.00
IUUC-Dno-029758	Dasypus novemcinctus	66.03	3.00e-143	501.00
IUUC-Dme-031929	Drosophila melanogaster	50.12	3.00e-93	335.00
IUUC-Eeu-035134	Erinaceus europaeus	67.21	1.00e-100	359.00
IUUC-Fca-036243	Felis catus	67.02	5.00e-146	510.00
IUUC-Fal-036600	Ficedula albicollis	70.79	2.00e-157	548.00
IUUC-Gmo-039665	Gadus morhua	61.80	1.00e-100	359.00
IUUC-Gga-040993	Gallus gallus	70.36	3.00e-158	551.00
IUUC-Gac-042342	Gasterosteus aculeatus	61.26	5.00e-118	417.00
IUUC-Ggo-044859	Gorilla gorilla	75.29	2.00e-124	438.00
IUUC-Hsa-046822	Homo sapiens	66.60	8.00e-147	513.00
IUUC-Loc-052469	Lepisosteus oculatus	77.30	4.00e-121	428.00
IUUC-Laf-053979	Loxodonta africana	67.78	2.00e-127	448.00
IUUC-Mcc-055682	Macaca mulatta	66.60	8.00e-147	513.00
IUUC-Meu-056004	Macropus eugenii	71.04	6.00e-123	434.00
IUUC-Mga-059466	Meleagris gallopavo	71.00	8.00e-159	553.00
IUUC-Mmr-061538	Microcebus murinus	60.73	1.00e-114	406.00
IUUC-Mdo-062122	Monodelphis domestica	66.81	2.00e-151	528.00
IUUC-Mmu-063176	Mus musculus	66.11	1.00e-141	495.00
IUUC-Mpu-065927	Mustela putorius furo	66.74	4.00e-147	514.00
IUUC-Mlu-067079	Myotis lucifugus	66.52	1.00e-150	526.00
IUUC-Nle-070180	Nomascus leucogenys	66.60	8.00e-147	513.00
IUUC-Opr-070847	Ochotona princeps	62.47	1.00e-130	459.00
IUUC-Ont-071846	Oreochromis niloticus	69.00	3.00e-132	465.00
IUUC-Oan-072783	Ornithorhynchus anatinus	63.91	3.00e-102	364.00
IUUC-Ocu-074527	Oryctolagus cuniculus	65.11	7.00e-145	507.00
IUUC-Obr-076302	Oryza brachyantha	29.65	5.00e-17	82.40
IUUC-Olo-080484	Oryza longistaminata	50.00	3.00e-07	48.90
IUUC-Oar-090348	Ovis aries	68.44	3.00e-149	521.00
IUUC-Ptr-091060	Pan troglodytes	66.60	8.00e-147	513.00
IUUC-Pan-091855	Papio anubis	64.92	5.00e-131	461.00
IUUC-Psi-093505	Pelodiscus sinensis	69.72	1.00e-157	549.00
IUUC-Pfo-097396	Poecilia formosa	70.99	1.00e-139	489.00
IUUC-Pab-098591	Pongo abelii	67.02	8.00e-147	513.00
IUUC-Pca-101029	Procavia capensis	64.47	2.00e-132	466.00
IUUC-Pva-102244	Pteropus vampyrus	63.11	6.00e-136	477.00
IUUC-Rno-105861	Rattus norvegicus	65.41	7.00e-140	490.00
IUUC-Sha-107045	Sarcophilus harrisii	66.45	1.00e-149	522.00
IUUC-Sit-110624	Setaria italica	30.09	6.00e-14	72.00
IUUC-Sly-110865	Solanum lycopersicum	61.29	2.00e-06	43.50
IUUC-Sar-113169	Sorex araneus	65.25	3.00e-101	362.00
IUUC-Sbi-114305	Sorghum bicolor	29.50	2.00e-13	70.10
IUUC-Ssc-115766	Sus scrofa	67.95	1.00e-147	516.00
IUUC-Tru-117732	Takifugu rubripes	67.84	4.00e-130	457.00
IUUC-Tsy-119624	Tarsius syrichta	60.30	2.00e-130	459.00
IUUC-Tni-119852	Tetraodon nigroviridis	62.65	1.00e-121	429.00
IUUC-Tae-125925	Triticum aestivum	29.32	2.00e-13	70.10
IUUC-Tbe-128148	Tupaia belangeri	63.71	2.00e-118	419.00
IUUC-Ttr-128793	Tursiops truncatus	65.25	9.00e-139	486.00
IUUC-Vpa-130625	Vicugna pacos	54.49	2.00e-106	379.00
IUUC-Xtr-131790	Xenopus tropicalis	69.28	4.00e-138	484.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence