iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053551

UUCD1 version

UUC-LoA-00138

Ensembl Protein ID

ENSLAFP00000003367.3

UniProt Accession

G3STI3; G3STI3_LOXAF

Protein Name

E3 ubiquitin-protein ligase

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000004029.3	ENSLAFT00000004032.3	ENSLAFP00000003367.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-134	449.2	590	922

Active Site

Position(s)	Description	Evidence
891	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 590  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASAI-NPDHLSYFCFIGRFIAMALFHGKFIDT 677
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   diee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 678  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---DIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMME 763
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d+++++ y++ yt++s++i+wFw+ ++e ++e r ++LqFv
   Q: 764  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNAVYRH-YTRNSKQIIWFWQLVKETDNEVRMRLLQFV 851
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 852  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 922
           *********************************************************************96 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVAVDGET KKTAKSSSSS 60
NPKWDEQLTV RVTPQSTLEF RVWSHHTLKA DALLGRATID LKQALLKHNR KLERVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACTG CTTCACCAAG GTCTGATACT AGTAATAACC ACAGTGGAAG GTTACAGTTA 60
CAGGTAACTG GTAAGTTAAC TTAAAATAGT GATTCTCTGA TGAAACTTTC TTTTTTTCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

lav:100662373

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	92.31	0.00e+00	1720.00
IUUC-Apl-003310	Anas platyrhynchos	83.12	0.00e+00	1533.00
IUUC-Aca-005388	Anolis carolinensis	79.48	0.00e+00	1443.00
IUUC-Bta-012857	Bos taurus	92.42	0.00e+00	1701.00
IUUC-Cel-018299	Caenorhabditis elegans	67.01	0.00e+00	838.00
IUUC-Cja-019448	Callithrix jacchus	92.85	0.00e+00	1741.00
IUUC-Cfa-020728	Canis familiaris	93.17	0.00e+00	1717.00
IUUC-Cpo-021635	Cavia porcellus	87.49	0.00e+00	1641.00
IUUC-Csa-023805	Chlorocebus sabaeus	94.01	0.00e+00	1309.00
IUUC-Cho-024943	Choloepus hoffmanni	82.50	0.00e+00	1175.00
IUUC-Cin-025212	Ciona intestinalis	73.53	0.00e+00	906.00
IUUC-Csv-026256	Ciona savignyi	72.32	0.00e+00	899.00
IUUC-Dre-028245	Danio rerio	71.63	0.00e+00	1219.00
IUUC-Dno-029618	Dasypus novemcinctus	92.85	0.00e+00	1725.00
IUUC-Dor-030665	Dipodomys ordii	77.60	0.00e+00	1162.00
IUUC-Dme-032041	Drosophila melanogaster	69.56	0.00e+00	895.00
IUUC-Ete-032779	Echinops telfairi	94.37	0.00e+00	1112.00
IUUC-Eca-033313	Equus caballus	91.98	0.00e+00	1677.00
IUUC-Eeu-035259	Erinaceus europaeus	84.18	0.00e+00	1526.00
IUUC-Fca-035420	Felis catus	91.22	0.00e+00	1701.00
IUUC-Fal-037335	Ficedula albicollis	82.45	0.00e+00	1520.00
IUUC-Gmo-039172	Gadus morhua	86.62	0.00e+00	1050.00
IUUC-Gga-040246	Gallus gallus	82.59	0.00e+00	1528.00
IUUC-Gac-042211	Gasterosteus aculeatus	91.47	0.00e+00	1166.00
IUUC-Ggo-045001	Gorilla gorilla	91.89	0.00e+00	1548.00
IUUC-Hsa-046544	Homo sapiens	92.96	0.00e+00	1742.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	90.81	0.00e+00	1666.00
IUUC-Lch-050398	Latimeria chalumnae	77.65	0.00e+00	1394.00
IUUC-Loc-052116	Lepisosteus oculatus	76.46	0.00e+00	1394.00
IUUC-Mga-059986	Meleagris gallopavo	82.96	0.00e+00	1532.00
IUUC-Mmr-060945	Microcebus murinus	90.26	0.00e+00	1670.00
IUUC-Mdo-063024	Monodelphis domestica	81.91	0.00e+00	1472.00
IUUC-Mmu-063202	Mus musculus	88.84	0.00e+00	1602.00
IUUC-Mpu-065773	Mustela putorius furo	92.76	0.00e+00	1706.00
IUUC-Mlu-067373	Myotis lucifugus	96.14	0.00e+00	646.00
IUUC-Nle-069188	Nomascus leucogenys	93.17	0.00e+00	1742.00
IUUC-Opr-070965	Ochotona princeps	87.43	0.00e+00	1606.00
IUUC-Ont-072226	Oreochromis niloticus	91.71	0.00e+00	1175.00
IUUC-Oan-073497	Ornithorhynchus anatinus	85.06	0.00e+00	1538.00
IUUC-Ocu-073891	Oryctolagus cuniculus	87.99	0.00e+00	1609.00
IUUC-Ola-087438	Oryzias latipes	91.37	0.00e+00	1164.00
IUUC-Oga-087922	Otolemur garnettii	91.35	0.00e+00	1687.00
IUUC-Oar-089317	Ovis aries	90.92	0.00e+00	1665.00
IUUC-Ptr-090484	Pan troglodytes	92.85	0.00e+00	1741.00
IUUC-Pan-092117	Papio anubis	93.07	0.00e+00	1741.00
IUUC-Psi-093338	Pelodiscus sinensis	83.66	0.00e+00	1555.00
IUUC-Pma-094279	Petromyzon marinus	72.76	0.00e+00	844.00
IUUC-Pfo-096171	Poecilia formosa	91.69	0.00e+00	1168.00
IUUC-Pab-098654	Pongo abelii	91.76	0.00e+00	1268.00
IUUC-Pca-100501	Procavia capensis	75.41	0.00e+00	917.00
IUUC-Pva-102811	Pteropus vampyrus	80.07	0.00e+00	1421.00
IUUC-Rno-106125	Rattus norvegicus	88.84	0.00e+00	1618.00
IUUC-Sha-107243	Sarcophilus harrisii	84.48	0.00e+00	1544.00
IUUC-Sre-114929	Sporisorium reilianum	45.52	7.00e-151	528.00
IUUC-Ssc-115368	Sus scrofa	92.55	0.00e+00	1695.00
IUUC-Tgu-117079	Taeniopygia guttata	82.35	0.00e+00	1510.00
IUUC-Tru-118062	Takifugu rubripes	91.84	0.00e+00	1170.00
IUUC-Tsy-119507	Tarsius syrichta	87.22	0.00e+00	1597.00
IUUC-Tni-120151	Tetraodon nigroviridis	91.36	0.00e+00	1157.00
IUUC-Ttr-129260	Tursiops truncatus	82.67	0.00e+00	1473.00
IUUC-Uma-129332	Ustilago maydis	45.52	1.00e-144	506.00
IUUC-Vpa-130390	Vicugna pacos	80.94	0.00e+00	907.00
IUUC-Xtr-132877	Xenopus tropicalis	69.64	0.00e+00	1223.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence