iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133778

Ensembl Protein ID

ENSXMAP00000004379.1

UniProt Accession

M3ZQ86; M3ZQ86_XIPMA

Genbank Protein ID

ENSXMAP00000004379

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGAJ01024344

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000004345.1	ENSXMAT00000004384.1	ENSXMAP00000004379.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.10e-135	449.8	626	958

Active Site

Position(s)	Description	Evidence
927	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 626  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASAI-NPDHLSYFCFIGRFIAMALFHGKFIDT 713
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl l+dle++dpe+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lkp+G+ni Vt+eNkeeY++l++e
   Q: 714  GFSLPFYKRMLNKKLILKDLESIDPEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKISSHDLKPDGANILVTEENKEEYISLMAE 799
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++ q++af +Gfnev+pl++l++F+e+ele+++cG++e+d++d++++t y++ yt++s++i+wFw+ ++e+++e r +++qFv
   Q: 800  WRFSRGVEGQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRH-YTRNSKQIIWFWQLVKEVDNEVRLRLMQFV 887
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 888  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 958
           *********************************************************************96 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MATASSRAET SHNHRRTSQL HAIVSCAKLK RKKSVFGAAI YVEVTAEGET RRTAKSHSSS 60
NPKWDERLTL TVAPHTQVDF KVWSHHTLKA DALLGKATLD LLQALERHDR KLENVKEVLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCATTATAA TGAGATAGTA TCTCAAAACA ATGAGATAAT ATCTCATTAT AATGAGATTT 60
TTTTTTATAT TTTTATTTTT TAACAGAGTG GCGGAAACGG GCTTCCATAT ATATAATAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

xma:102223052

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	70.33	0.00e+00	1300.00
IUUC-Apl-003310	Anas platyrhynchos	93.65	0.00e+00	1152.00
IUUC-Aca-005388	Anolis carolinensis	93.14	0.00e+00	1146.00
IUUC-Bta-012857	Bos taurus	92.20	0.00e+00	1139.00
IUUC-Cel-018299	Caenorhabditis elegans	67.76	0.00e+00	842.00
IUUC-Cja-019448	Callithrix jacchus	92.81	0.00e+00	1140.00
IUUC-Cfa-020728	Canis familiaris	92.03	0.00e+00	1142.00
IUUC-Cpo-021635	Cavia porcellus	89.78	0.00e+00	1129.00
IUUC-Csa-023805	Chlorocebus sabaeus	92.66	0.00e+00	1127.00
IUUC-Cin-025212	Ciona intestinalis	73.58	0.00e+00	911.00
IUUC-Csv-026256	Ciona savignyi	72.84	0.00e+00	907.00
IUUC-Dre-028245	Danio rerio	95.59	0.00e+00	1199.00
IUUC-Dno-029618	Dasypus novemcinctus	92.64	0.00e+00	1139.00
IUUC-Dme-032041	Drosophila melanogaster	71.00	0.00e+00	900.00
IUUC-Ete-032779	Echinops telfairi	89.61	0.00e+00	1060.00
IUUC-Eeu-035259	Erinaceus europaeus	81.51	0.00e+00	976.00
IUUC-Fca-035420	Felis catus	92.03	0.00e+00	1142.00
IUUC-Fal-037335	Ficedula albicollis	71.04	0.00e+00	1336.00
IUUC-Gmo-039172	Gadus morhua	90.48	0.00e+00	1092.00
IUUC-Gga-040246	Gallus gallus	93.65	0.00e+00	1155.00
IUUC-Gac-042211	Gasterosteus aculeatus	97.95	0.00e+00	1232.00
IUUC-Ggo-045001	Gorilla gorilla	92.47	0.00e+00	1136.00
IUUC-Hsa-046544	Homo sapiens	92.47	0.00e+00	1139.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	71.19	0.00e+00	1300.00
IUUC-Lch-050398	Latimeria chalumnae	92.32	0.00e+00	1164.00
IUUC-Loc-052116	Lepisosteus oculatus	95.94	0.00e+00	1209.00
IUUC-Laf-053551	Loxodonta africana	91.69	0.00e+00	1135.00
IUUC-Mga-059986	Meleagris gallopavo	71.80	0.00e+00	1335.00
IUUC-Mmr-060945	Microcebus murinus	88.36	0.00e+00	1069.00
IUUC-Mdo-063024	Monodelphis domestica	92.74	0.00e+00	1082.00
IUUC-Mmu-063202	Mus musculus	91.82	0.00e+00	1132.00
IUUC-Mpu-065773	Mustela putorius furo	91.55	0.00e+00	1137.00
IUUC-Nle-069188	Nomascus leucogenys	92.81	0.00e+00	1140.00
IUUC-Ont-072226	Oreochromis niloticus	98.47	0.00e+00	1248.00
IUUC-Oan-073497	Ornithorhynchus anatinus	94.52	0.00e+00	1154.00
IUUC-Ola-087438	Oryzias latipes	97.96	0.00e+00	1241.00
IUUC-Oga-087922	Otolemur garnettii	92.32	0.00e+00	1135.00
IUUC-Oar-089317	Ovis aries	91.71	0.00e+00	1132.00
IUUC-Ptr-090484	Pan troglodytes	92.47	0.00e+00	1140.00
IUUC-Pan-092117	Papio anubis	92.98	0.00e+00	1144.00
IUUC-Psi-093338	Pelodiscus sinensis	92.65	0.00e+00	1155.00
IUUC-Pma-094279	Petromyzon marinus	73.17	0.00e+00	838.00
IUUC-Pfo-096171	Poecilia formosa	99.83	0.00e+00	1262.00
IUUC-Pab-098654	Pongo abelii	90.07	0.00e+00	1088.00
IUUC-Pva-102811	Pteropus vampyrus	92.01	0.00e+00	1132.00
IUUC-Rno-106125	Rattus norvegicus	91.82	0.00e+00	1130.00
IUUC-Sha-107243	Sarcophilus harrisii	90.71	0.00e+00	1135.00
IUUC-Ssc-115368	Sus scrofa	91.72	0.00e+00	1134.00
IUUC-Tgu-117079	Taeniopygia guttata	93.48	0.00e+00	1152.00
IUUC-Tru-118062	Takifugu rubripes	97.62	0.00e+00	1237.00
IUUC-Tsy-119507	Tarsius syrichta	84.75	0.00e+00	1026.00
IUUC-Tni-120151	Tetraodon nigroviridis	97.45	0.00e+00	1221.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence