iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-105029

UUCD1 version

UUC-RaN-00834

Ensembl Protein ID

ENSRNOP00000010399.5

UniProt Accession

Q5I0I2; MARH2_RAT

Genbank Protein ID

BAD89357.1; AAH88286.1

Protein Name

E3 ubiquitin-protein ligase MARCH2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING-type E3 ubiquitin transferase MARCH2

Genbank Nucleotide ID

AB048838; BC088286

Gene Name

March2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000007769.7	ENSRNOT00000010399.7	ENSRNOP00000010399.5
ENSRNOG00000007769.7	ENSRNOT00000090849.1	ENSRNOP00000072726.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	95.53	3.00e-135	478.00	IUUC-Hsa-046263
E3 activity/RING/RING	26.26	2.00e-10	63.20	IUUC-Oin-080134

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.

Protein Sequence
(Fasta)

MTTGDCCHLP GSLCDCSSSP AFSKVVEATG LGPPQYVAQV TSRDGRLLST VIRALDTPSD 60
CPFCRICHEG ANGENLLSPC GCTGTLGAVH KSCLEKWLSS SNTSYCELCH TEFAVEKRPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGGAGCCG GAGCAAGCCG CTGCTGACGG GCCGGGCCGG GCCGGGACCC GGGCCAGGGA 60
GAACCGAGGG GCCTGCGCGG CCGCCCGGCC CGGCCGCGGA ACAGGTAGGC ACCGAAGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0254--Endocytosis
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0010008--C:endosome membrane
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0016567--P:protein ubiquitination

KEGG

rno:362849

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002189	Ailuropoda melanoleuca	94.31	5.00e-131	459.00
IUUC-Apl-004200	Anas platyrhynchos	80.33	2.00e-111	394.00
IUUC-Ame-010786	Astyanax mexicanus	78.86	6.00e-107	379.00
IUUC-Bta-012678	Bos taurus	91.46	6.00e-131	459.00
IUUC-Bol-015895	Brassica oleracea	34.21	2.00e-09	56.20
IUUC-Bra-018016	Brassica rapa	34.21	2.00e-09	56.20
IUUC-Cja-019315	Callithrix jacchus	93.09	3.00e-101	360.00
IUUC-Cfa-020820	Canis familiaris	93.55	7.00e-135	472.00
IUUC-Cpo-021511	Cavia porcellus	93.50	2.00e-136	477.00
IUUC-Dre-028107	Danio rerio	77.51	2.00e-104	371.00
IUUC-Dno-029379	Dasypus novemcinctus	92.68	6.00e-123	432.00
IUUC-Dor-031059	Dipodomys ordii	93.50	5.00e-136	476.00
IUUC-Eca-034013	Equus caballus	89.84	9.00e-124	435.00
IUUC-Eeu-035139	Erinaceus europaeus	91.13	1.00e-62	231.00
IUUC-Fca-035894	Felis catus	94.72	5.00e-136	476.00
IUUC-Fal-037434	Ficedula albicollis	77.24	1.00e-103	369.00
IUUC-Gmo-039276	Gadus morhua	75.31	7.00e-105	372.00
IUUC-Gga-041224	Gallus gallus	78.86	7.00e-112	396.00
IUUC-Gac-042104	Gasterosteus aculeatus	73.39	4.00e-106	377.00
IUUC-Gma-043460	Glycine max	29.89	2.00e-10	59.70
IUUC-Ggo-045297	Gorilla gorilla	97.45	8.00e-110	389.00
IUUC-Hsa-046263	Homo sapiens	95.53	1.00e-136	478.00
IUUC-Itr-048963	Ictidomys tridecemlineatus	95.53	9.00e-139	485.00
IUUC-Lch-050103	Latimeria chalumnae	78.86	1.00e-108	385.00
IUUC-Lpe-051137	Leersia perrieri	23.77	4.00e-12	65.10
IUUC-Loc-052480	Lepisosteus oculatus	70.73	1.00e-101	362.00
IUUC-Laf-054410	Loxodonta africana	92.68	1.00e-134	472.00
IUUC-Mcc-054712	Macaca mulatta	95.93	2.00e-137	481.00
IUUC-Mga-060053	Meleagris gallopavo	78.46	5.00e-113	400.00
IUUC-Mdo-062010	Monodelphis domestica	79.27	1.00e-115	408.00
IUUC-Mmu-064040	Mus musculus	96.75	1.00e-140	492.00
IUUC-Mpu-066205	Mustela putorius furo	93.90	2.00e-135	474.00
IUUC-Mlu-067013	Myotis lucifugus	90.36	6.00e-129	452.00
IUUC-Opr-070698	Ochotona princeps	70.33	5.00e-87	313.00
IUUC-Ont-071768	Oreochromis niloticus	75.00	4.00e-106	377.00
IUUC-Oan-073269	Ornithorhynchus anatinus	62.90	1.00e-83	302.00
IUUC-Ocu-074212	Oryctolagus cuniculus	93.09	5.00e-135	473.00
IUUC-Oba-075487	Oryza barthii	44.00	3.00e-09	55.80
IUUC-Obr-076417	Oryza brachyantha	28.87	1.00e-10	60.10
IUUC-Ogl-077311	Oryza glaberrima	26.12	1.00e-11	63.50
IUUC-Ogu-078495	Oryza glumaepatula	30.47	6.00e-10	58.20
IUUC-Oin-080134	Oryza indica	24.59	2.00e-11	63.20
IUUC-Olo-080407	Oryza longistaminata	46.81	9.00e-10	55.50
IUUC-Ome-081252	Oryza meridionalis	44.00	2.00e-09	56.20
IUUC-Opu-083597	Oryza punctata	44.00	2.00e-09	55.80
IUUC-Oru-084860	Oryza rufipogon	44.00	2.00e-09	55.50
IUUC-Osa-085741	Oryza sativa	26.12	1.00e-11	63.50
IUUC-Ola-087137	Oryzias latipes	71.00	4.00e-92	330.00
IUUC-Oga-088712	Otolemur garnettii	93.90	3.00e-135	473.00
IUUC-Oar-090175	Ovis aries	91.46	4.00e-129	453.00
IUUC-Pan-092276	Papio anubis	95.53	2.00e-136	478.00
IUUC-Psi-094007	Pelodiscus sinensis	80.08	1.00e-115	408.00
IUUC-Pfo-097509	Poecilia formosa	76.68	9.00e-99	352.00
IUUC-Pca-100424	Procavia capensis	91.87	4.00e-133	466.00
IUUC-Ppe-101927	Prunus persica	29.79	5.00e-10	58.20
IUUC-Pva-102806	Pteropus vampyrus	94.72	1.00e-137	482.00
IUUC-Sha-106628	Sarcophilus harrisii	79.27	4.00e-115	407.00
IUUC-Sit-110468	Setaria italica	40.00	1.00e-09	57.00
IUUC-Sbi-114312	Sorghum bicolor	37.10	5.00e-10	58.20
IUUC-Ssc-115689	Sus scrofa	94.72	2.00e-136	477.00
IUUC-Tgu-116681	Taeniopygia guttata	77.91	2.00e-112	398.00
IUUC-Tru-118517	Takifugu rubripes	71.37	3.00e-95	340.00
IUUC-Tni-120353	Tetraodon nigroviridis	68.67	1.00e-97	348.00
IUUC-Tae-122991	Triticum aestivum	40.00	2.00e-09	56.20
IUUC-Ttr-128265	Tursiops truncatus	94.31	8.00e-136	475.00
IUUC-Xtr-132814	Xenopus tropicalis	78.46	1.00e-109	388.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence