iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003531

Ensembl Protein ID

ENSAPLP00000007764.1

UniProt Accession

U3IKJ2; U3IKJ2_ANAPL

Genbank Protein ID

ENSAPLP00000007764

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01013390

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000007997.1	ENSAPLT00000008429.1	ENSAPLP00000007764.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.80e-79	265.0	1607	1983

Active Site

Position(s)	Description	Evidence
1950	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp..................ehlklFe 72
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++++n                   ++   F+
   Q: 1607 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLANPKgsQEGTKYIHNLqglfalpfgrtakpahiaKVKMKFR 1692
           56899***********.**********************766663333330023334444448999999**********9999**** PP
   S: 73   flGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikenaes........................... 130
           flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp ++ks+  +++ + +                           
   Q: 1693 FLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFSIDPVVAKSIYHLEDIVRQkkrleqdktqtkeslqyalealtmngc 1779
           *******************************654444*************9999999833344555566666667555555555544 PP
   S: 131  dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklv.veyrlkegikeqveafreGfneviplellslFte 211
           ++e+            +     l+   + eLk gG+++pVt+ N+eeY + + +++  ++g  + ++ +r+ f   +pl +l     
   Q: 1780 SVED------------LgldftLPGFPNIELKKGGKDTPVTIHNLEEYLRFMlINWEQNQGNSSDLHTLRSQF---FPLGSLYQV-S 1850
           4444............24444478999***********************7648****************855...666655544.3 PP
   S: 212  eelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk..... 291
           + le+l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f+se+++ fLqFvTgs+rlP+gGf++l+p l+++rk     
   Q: 1851 NMLEQLLCGSktDTWDAKTLMECCRPDHGYTHDSRAVKYLFEILSSFDSEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfest 1937
           679******97778999999999999***********************************************************98 PP
   S: 292  dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
           ++ dd lPs++TC+nyLkLP+Ys+ ei++ekLl+A +e+ ++F+ls
   Q: 1938 ENPDDFLPSVMTCVNYLKLPDYSTIEIMREKLLIAAREGqQSFHLS 1983
           8888***************************************985 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

SHLGQAKHKA HSPPESRKSI SKTPKVQSNT TSEQSKGHFS RRGCSSSAVL VPQQEDPERV 60
NTSEKQKTGQ VPKKENSRGV KRSASPDYSR TNSPSSAKKP KALQHTETSL ETNKPHTKSK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCAGTGAAT GATAGTGTCT AGAAAGGGTA TGTCCCTTCA GGAGAGAGGT GCCAATGTCC 60
AACCGGCCTA ATAACAATCC AGGGGGGTCA CTGCGACGTT CACAGAGGAA CACTGCTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	37.32	2.00e-115	411.00
IUUC-Aml-001502	Ailuropoda melanoleuca	92.84	0.00e+00	3413.00
IUUC-Atr-002821	Amborella trichopoda	36.12	1.00e-106	381.00
IUUC-Aly-005962	Arabidopsis lyrata	37.46	4.00e-104	373.00
IUUC-Ath-006636	Arabidopsis thaliana	37.32	1.00e-103	372.00
IUUC-Ago-007875	Ashbya gossypii	34.83	2.00e-74	274.00
IUUC-Acl-008242	Aspergillus clavatus	34.24	2.00e-104	374.00
IUUC-Afl-008736	Aspergillus flavus	36.12	2.00e-100	360.00
IUUC-Afu-008812	Aspergillus fumigatus	33.43	2.00e-105	377.00
IUUC-Ani-009407	Aspergillus nidulans	35.61	2.00e-102	367.00
IUUC-Ang-009763	Aspergillus niger	37.94	5.00e-98	353.00
IUUC-Aor-009941	Aspergillus oryzae	29.65	1.00e-102	368.00
IUUC-Ate-010459	Aspergillus terreus	31.77	3.00e-77	283.00
IUUC-Ame-011761	Astyanax mexicanus	85.82	0.00e+00	2878.00
IUUC-Bgr-012265	Blumeria graminis	33.33	3.00e-94	340.00
IUUC-Bta-013070	Bos taurus	91.98	0.00e+00	3345.00
IUUC-Bci-013890	Botrytis cinerea	37.52	7.00e-93	335.00
IUUC-Bdi-014046	Brachypodium distachyon	36.98	4.00e-112	399.00
IUUC-Bol-015942	Brassica oleracea	39.24	5.00e-103	369.00
IUUC-Bra-016849	Brassica rapa	42.03	2.00e-102	368.00
IUUC-Cja-019046	Callithrix jacchus	91.25	0.00e+00	3389.00
IUUC-Cfa-020521	Canis familiaris	90.90	0.00e+00	3296.00
IUUC-Cpo-021639	Cavia porcellus	88.57	0.00e+00	3293.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	38.08	6.00e-81	294.00
IUUC-Csa-023231	Chlorocebus sabaeus	91.07	0.00e+00	3380.00
IUUC-Cho-024380	Choloepus hoffmanni	84.88	0.00e+00	3091.00
IUUC-Cin-025482	Ciona intestinalis	48.88	7.00e-146	510.00
IUUC-Csv-026121	Ciona savignyi	48.09	0.00e+00	1496.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	33.38	2.00e-100	361.00
IUUC-Cne-026857	Cryptococcus neoformans	37.59	2.00e-89	324.00
IUUC-Cme-027226	Cyanidioschyzon merolae	33.47	5.00e-68	253.00
IUUC-Dre-028174	Danio rerio	86.07	0.00e+00	2924.00
IUUC-Dor-030939	Dipodomys ordii	85.81	0.00e+00	2721.00
IUUC-Dse-031444	Dothistroma septosporum	36.69	3.00e-95	343.00
IUUC-Dme-032162	Drosophila melanogaster	57.56	0.00e+00	681.00
IUUC-Ete-032345	Echinops telfairi	87.70	0.00e+00	2174.00
IUUC-Eca-033229	Equus caballus	92.19	0.00e+00	3339.00
IUUC-Eeu-035205	Erinaceus europaeus	80.67	0.00e+00	2859.00
IUUC-Fca-036444	Felis catus	92.10	0.00e+00	3393.00
IUUC-Fal-037131	Ficedula albicollis	94.55	0.00e+00	3465.00
IUUC-Fox-038035	Fusarium oxysporum	34.45	3.00e-100	359.00
IUUC-Fso-038320	Fusarium solani	34.09	1.00e-99	358.00
IUUC-Gmo-039497	Gadus morhua	87.33	0.00e+00	2958.00
IUUC-Ggr-040057	Gaeumannomyces graminis	36.84	1.00e-96	348.00
IUUC-Gga-041021	Gallus gallus	94.84	0.00e+00	3492.00
IUUC-Gac-042474	Gasterosteus aculeatus	81.30	0.00e+00	2977.00
IUUC-Gma-043060	Glycine max	37.87	1.00e-110	395.00
IUUC-Ggo-044855	Gorilla gorilla	91.25	0.00e+00	3389.00
IUUC-Hsa-046147	Homo sapiens	91.34	0.00e+00	3316.00
IUUC-Hvu-047775	Hordeum vulgare	37.17	4.00e-113	403.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	91.16	0.00e+00	3237.00
IUUC-Kpa-049098	Komagataella pastoris	36.51	8.00e-77	282.00
IUUC-Lch-049818	Latimeria chalumnae	84.03	0.00e+00	2972.00
IUUC-Lpe-051017	Leersia perrieri	37.27	3.00e-108	387.00
IUUC-Loc-051777	Lepisosteus oculatus	85.48	0.00e+00	3200.00
IUUC-Lma-052990	Leptosphaeria maculans	34.19	3.00e-104	373.00
IUUC-Laf-053727	Loxodonta africana	92.39	0.00e+00	3394.00
IUUC-Mcc-055799	Macaca mulatta	89.59	0.00e+00	3288.00
IUUC-Meu-056065	Macropus eugenii	91.09	0.00e+00	2009.00
IUUC-Mor-057054	Magnaporthe oryzae	36.76	4.00e-96	347.00
IUUC-Mpo-057417	Magnaporthe poae	37.10	9.00e-98	352.00
IUUC-Mtr-057849	Medicago truncatula	36.33	7.00e-104	372.00
IUUC-Mla-058870	Melampsora laricipopulina	40.48	1.00e-96	348.00
IUUC-Mga-059580	Meleagris gallopavo	97.36	0.00e+00	3121.00
IUUC-Mvi-060507	Microbotryum violaceum	38.35	3.00e-106	380.00
IUUC-Mmr-060816	Microcebus murinus	90.58	0.00e+00	3386.00
IUUC-Mdo-062866	Monodelphis domestica	88.85	0.00e+00	3187.00
IUUC-Mmu-063906	Mus musculus	91.20	0.00e+00	3311.00
IUUC-Mac-064675	Musa acuminata	37.25	2.00e-102	366.00
IUUC-Mpu-066199	Mustela putorius furo	89.79	0.00e+00	3278.00
IUUC-Mlu-067110	Myotis lucifugus	91.30	0.00e+00	3304.00
IUUC-Nfi-068482	Neosartorya fischeri	33.43	8.00e-105	375.00
IUUC-Ncr-068906	Neurospora crassa	33.23	2.00e-99	358.00
IUUC-Nle-069410	Nomascus leucogenys	91.99	0.00e+00	3379.00
IUUC-Opr-070401	Ochotona princeps	83.18	0.00e+00	2964.00
IUUC-Ont-072100	Oreochromis niloticus	81.07	0.00e+00	2988.00
IUUC-Oan-073121	Ornithorhynchus anatinus	91.21	0.00e+00	3441.00
IUUC-Ocu-074623	Oryctolagus cuniculus	89.79	0.00e+00	3318.00
IUUC-Oba-075380	Oryza barthii	35.86	2.00e-105	377.00
IUUC-Obr-076915	Oryza brachyantha	36.86	2.00e-109	391.00
IUUC-Ogl-077055	Oryza glaberrima	37.54	6.00e-108	385.00
IUUC-Ogu-078892	Oryza glumaepatula	39.25	1.00e-104	375.00
IUUC-Oin-079256	Oryza indica	36.94	2.00e-106	381.00
IUUC-Olo-080343	Oryza longistaminata	36.52	2.00e-106	380.00
IUUC-Ome-081422	Oryza meridionalis	36.52	2.00e-106	381.00
IUUC-Oni-083047	Oryza nivara	39.57	7.00e-106	379.00
IUUC-Opu-083792	Oryza punctata	35.40	8.00e-99	355.00
IUUC-Oru-084439	Oryza rufipogon	39.57	7.00e-105	375.00
IUUC-Osa-085972	Oryza sativa	37.25	1.00e-106	380.00
IUUC-Ola-087173	Oryzias latipes	80.05	0.00e+00	2937.00
IUUC-Olu-087871	Ostreococcus lucimarinus	35.85	1.00e-79	290.00
IUUC-Oga-087908	Otolemur garnettii	90.81	0.00e+00	3405.00
IUUC-Oar-090277	Ovis aries	90.58	0.00e+00	3326.00
IUUC-Ptr-091543	Pan troglodytes	91.34	0.00e+00	3316.00
IUUC-Pan-092243	Papio anubis	89.54	0.00e+00	3287.00
IUUC-Psi-093150	Pelodiscus sinensis	93.98	0.00e+00	3506.00
IUUC-Pno-094891	Phaeosphaeria nodorum	39.40	2.00e-104	374.00
IUUC-Ppa-095181	Physcomitrella patens	40.50	1.00e-97	350.00
IUUC-Pfo-096267	Poecilia formosa	81.35	0.00e+00	2930.00
IUUC-Pab-098072	Pongo abelii	92.29	0.00e+00	3390.00
IUUC-Pop-099190	Populus trichocarpa	35.81	2.00e-104	374.00
IUUC-Pca-100311	Procavia capensis	86.06	0.00e+00	3098.00
IUUC-Ppe-101284	Prunus persica	36.22	4.00e-105	377.00
IUUC-Pva-102215	Pteropus vampyrus	90.53	0.00e+00	1244.00
IUUC-Pgr-103694	Puccinia graminis	38.00	3.00e-92	333.00
IUUC-Ptt-103916	Puccinia triticina	36.42	6.00e-86	313.00
IUUC-Pte-104346	Pyrenophora teres	37.31	2.00e-100	360.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	37.01	2.00e-100	361.00
IUUC-Rno-105315	Rattus norvegicus	89.30	0.00e+00	3240.00
IUUC-Sce-106273	Saccharomyces cerevisiae	32.96	2.00e-61	231.00
IUUC-Sha-106835	Sarcophilus harrisii	92.05	0.00e+00	3462.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	36.77	1.00e-89	325.00
IUUC-Spo-108081	Schizosaccharomyces pombe	37.12	4.00e-88	320.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	37.52	3.00e-96	347.00
IUUC-Smo-109590	Selaginella moellendorffii	41.53	4.00e-103	370.00
IUUC-Sit-110717	Setaria italica	37.08	4.00e-110	393.00
IUUC-Sly-111469	Solanum lycopersicum	38.02	4.00e-112	400.00
IUUC-Stu-112896	Solanum tuberosum	36.89	4.00e-95	342.00
IUUC-Sar-113224	Sorex araneus	85.68	0.00e+00	1782.00
IUUC-Sbi-113884	Sorghum bicolor	37.48	2.00e-113	403.00
IUUC-Sre-114993	Sporisorium reilianum	31.95	8.00e-92	332.00
IUUC-Ssc-115535	Sus scrofa	87.98	0.00e+00	3204.00
IUUC-Tgu-117493	Taeniopygia guttata	97.01	0.00e+00	2826.00
IUUC-Tru-118669	Takifugu rubripes	81.37	0.00e+00	2952.00
IUUC-Tsy-119373	Tarsius syrichta	88.38	0.00e+00	1731.00
IUUC-Tni-120049	Tetraodon nigroviridis	76.63	0.00e+00	851.00
IUUC-Tca-121779	Theobroma cacao	37.99	7.00e-106	379.00
IUUC-Tre-122195	Trichoderma reesei	34.09	8.00e-96	345.00
IUUC-Tvi-122650	Trichoderma virens	34.13	5.00e-98	353.00
IUUC-Tae-123580	Triticum aestivum	37.09	8.00e-114	404.00
IUUC-Tur-126295	Triticum urartu	37.17	2.00e-115	410.00
IUUC-Tme-126964	Tuber melanosporum	38.10	2.00e-96	348.00
IUUC-Tbe-128149	Tupaia belangeri	75.82	0.00e+00	1342.00
IUUC-Ttr-128165	Tursiops truncatus	92.05	0.00e+00	2923.00
IUUC-Uma-129365	Ustilago maydis	33.93	6.00e-81	296.00
IUUC-Vda-129725	Verticillium dahliae	38.48	2.00e-98	354.00
IUUC-Vpa-130678	Vicugna pacos	93.91	0.00e+00	2550.00
IUUC-Vvi-131147	Vitis vinifera	38.49	2.00e-111	397.00
IUUC-Xtr-132636	Xenopus tropicalis	87.32	0.00e+00	3154.00
IUUC-Xma-133458	Xiphophorus maculatus	81.50	0.00e+00	2972.00
IUUC-Yli-134481	Yarrowia lipolytica	37.38	8.00e-90	325.00
IUUC-Zma-135657	Zea mays	37.29	4.00e-112	400.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence