iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065936

Ensembl Protein ID

ENSMPUP00000011871.1

UniProt Accession

M3YKL4; M3YKL4_MUSPF

Genbank Protein ID

ENSMPUP00000011871

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01092538

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000011963.1	ENSMPUT00000012066.1	ENSMPUP00000011871.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-101	339.6	663	986

Active Site

Position(s)	Description	Evidence
955	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl++
   Q: 663  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDLHF 746
           78999***********************************************88877.....689************************ PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
           + ++yk+ll+kk sl+dl+e+ p++ +s+++++++ e+d+ee+ ++l+f+++ e++g t+++eL+ +G+++ V+++N++e+v+++v+y+
   Q: 747  PLALYKKLLKKKPSLDDLKELVPDVGRSMQQLLDYPEDDVEET-FCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYI 834
           ***********************************99999997.********************************************* PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           +++++++ ++af++Gf++v+  ++l+lF+++el+ ++ G++++d+++l+k+t+ykg+y +++p+i+ Fwev++e+  e++k+fL F+Tg
   Q: 835  FNKSVASLFDAFHAGFHKVCGGKVLQLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTG 923
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+r+P+ G+++lk    vi+   + ++ lP s+TCfn+L+LP+Y+ ke+l++kL+ Ai++++gF+l
   Q: 924  SDRIPILGMKSLK---LVIQStGGGEEYLPVSHTCFNLLDLPKYKDKETLRSKLIQAIDHNEGFSL 986
           *************...7777758889**************************************86 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MAAQVEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLLG SEECIRVPRN 60
IKSLSDIQVV QVACGYYHSL ALSKASEVFS WGQNKYGQLG LGIDCKKQAS PQLIKSLLGI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACATAGGTAT ACCTCCAACT TTCCAGTGTT TCAGAAGGAA GTTTTTTTAT TGAAACTGGA 60
AGACCAAAAG AATTACAAAC ATGTTGTGCT GGGGAAATGC ATCTTTTGGA CAGCTAGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	98.98	0.00e+00	1871.00
IUUC-Apl-003295	Anas platyrhynchos	88.10	0.00e+00	1727.00
IUUC-Aca-004336	Anolis carolinensis	85.79	0.00e+00	1680.00
IUUC-Ame-010768	Astyanax mexicanus	72.33	0.00e+00	1443.00
IUUC-Bta-013279	Bos taurus	98.37	0.00e+00	1858.00
IUUC-Cja-019023	Callithrix jacchus	97.45	0.00e+00	1844.00
IUUC-Cfa-021074	Canis familiaris	98.78	0.00e+00	1868.00
IUUC-Cpo-021461	Cavia porcellus	95.02	0.00e+00	1789.00
IUUC-Csa-024261	Chlorocebus sabaeus	97.96	0.00e+00	1855.00
IUUC-Cho-024513	Choloepus hoffmanni	76.15	0.00e+00	1324.00
IUUC-Cin-025232	Ciona intestinalis	43.66	0.00e+00	798.00
IUUC-Dre-028829	Danio rerio	73.81	0.00e+00	1424.00
IUUC-Dno-029445	Dasypus novemcinctus	94.71	0.00e+00	1627.00
IUUC-Dor-030158	Dipodomys ordii	96.48	0.00e+00	877.00
IUUC-Ete-033072	Echinops telfairi	85.95	0.00e+00	1573.00
IUUC-Eca-033317	Equus caballus	96.54	0.00e+00	1819.00
IUUC-Fca-035682	Felis catus	98.17	0.00e+00	1847.00
IUUC-Fal-036969	Ficedula albicollis	86.86	0.00e+00	1704.00
IUUC-Gmo-038671	Gadus morhua	73.48	0.00e+00	1448.00
IUUC-Gga-041174	Gallus gallus	87.88	0.00e+00	1727.00
IUUC-Gac-042600	Gasterosteus aculeatus	73.60	0.00e+00	1392.00
IUUC-Ggo-044589	Gorilla gorilla	97.45	0.00e+00	1875.00
IUUC-Hsa-046772	Homo sapiens	97.35	0.00e+00	1874.00
IUUC-Lch-050147	Latimeria chalumnae	80.14	0.00e+00	1293.00
IUUC-Loc-052684	Lepisosteus oculatus	80.75	0.00e+00	1580.00
IUUC-Laf-053844	Loxodonta africana	96.84	0.00e+00	1835.00
IUUC-Mcc-055531	Macaca mulatta	95.53	0.00e+00	1843.00
IUUC-Mga-060151	Meleagris gallopavo	87.03	0.00e+00	1407.00
IUUC-Mmr-060954	Microcebus murinus	97.66	0.00e+00	1844.00
IUUC-Mdo-062246	Monodelphis domestica	91.79	0.00e+00	1784.00
IUUC-Mmu-063369	Mus musculus	95.52	0.00e+00	1821.00
IUUC-Mlu-067326	Myotis lucifugus	97.56	0.00e+00	1813.00
IUUC-Nle-069453	Nomascus leucogenys	96.74	0.00e+00	1824.00
IUUC-Ont-071720	Oreochromis niloticus	74.21	0.00e+00	1442.00
IUUC-Oan-073464	Ornithorhynchus anatinus	92.88	0.00e+00	1805.00
IUUC-Ocu-074207	Oryctolagus cuniculus	95.08	0.00e+00	1853.00
IUUC-Ola-086762	Oryzias latipes	73.19	0.00e+00	1393.00
IUUC-Oga-088435	Otolemur garnettii	97.56	0.00e+00	1845.00
IUUC-Oar-089233	Ovis aries	98.47	0.00e+00	1859.00
IUUC-Ptr-091368	Pan troglodytes	97.56	0.00e+00	1877.00
IUUC-Pan-092300	Papio anubis	97.96	0.00e+00	1855.00
IUUC-Psi-093406	Pelodiscus sinensis	89.51	0.00e+00	1751.00
IUUC-Pma-094113	Petromyzon marinus	71.89	0.00e+00	1144.00
IUUC-Pfo-097021	Poecilia formosa	73.12	0.00e+00	1456.00
IUUC-Pab-098327	Pongo abelii	97.56	0.00e+00	1878.00
IUUC-Pca-101075	Procavia capensis	95.34	0.00e+00	814.00
IUUC-Pva-102909	Pteropus vampyrus	85.74	0.00e+00	1543.00
IUUC-Rno-105457	Rattus norvegicus	96.23	0.00e+00	1842.00
IUUC-Sha-106632	Sarcophilus harrisii	92.97	0.00e+00	1794.00
IUUC-Sar-113679	Sorex araneus	88.05	0.00e+00	1146.00
IUUC-Tgu-116849	Taeniopygia guttata	82.69	0.00e+00	1600.00
IUUC-Tru-118206	Takifugu rubripes	72.05	0.00e+00	1338.00
IUUC-Tsy-119521	Tarsius syrichta	81.77	0.00e+00	1440.00
IUUC-Tni-120233	Tetraodon nigroviridis	71.11	0.00e+00	1327.00
IUUC-Tbe-127941	Tupaia belangeri	80.28	0.00e+00	1363.00
IUUC-Ttr-128926	Tursiops truncatus	98.19	0.00e+00	1147.00
IUUC-Vpa-130448	Vicugna pacos	97.96	0.00e+00	1850.00
IUUC-Xtr-132719	Xenopus tropicalis	72.23	0.00e+00	1318.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence