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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046095
UUCD1 version UUC-HoS-00368
Ensembl Protein ID ENSP00000384644.1
UniProt Accession Q9H511; A6N9J2; B2RP49; KLH31_HUMAN
Genbank Protein ID ABR23528.1; CAC16284.1; EAX04428.1; AAI37268.1; AAI37270.1
Protein Name Kelch-like protein 31; BTB and kelch domain-containing protein 6; Kelch repeat and BTB domain-containing protein 1; Kelch-like protein KLHL
Genbank Nucleotide ID EF633513; AL157773; CH471081; BC137267; BC137269
Gene Name KLHL31; BKLHD6; KBTBD1; KLHL
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000124743.5 ENST00000407079.1 ENSP00000384644.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitemiRTarBasemicroRNA
TRANSFACRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
iRefIndexMentha
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 2.30e-09 39.1 73 135
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +D ++  + + f +hk+v+a++S++Fy+ ++++ + +    +v+++d++p  + +++ + Ytgkl++
   Q: 73   CDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPSIQ----RVDLNDISPLGLATVIAYAYTGKLTL 135
           566666679*********************9988866....5**********************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).
 Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).
Protein Sequence
(Fasta)
MAPKKKIVKK NKGDINEMTI IVEDSPLNKL NALNGLLEGG NGLSCISSEL TDASYGPNLL 60
EGLSKMRQEN FLCDLVIGTK TKSFDVHKSV MASCSEYFYN ILKKDPSIQR VDLNDISPLG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046095|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCGGATTTT CCTTCTCCCT CTCTCTATCT CCACAGATCC CTTCCCAAGA GGAGTCTCCT 60
GCTAAAACTT CATCATCTCA AGTTGACCTG CCACTTCACC CAAGGAGGGT AAGGAGCTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046095|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0488--Methylation
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030604--KLHL31
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007519--P:skeletal muscle tissue development
GO:0006351--P:transcription, DNA-templated
KEGG hsa:401265
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001763 Ailuropoda melanoleuca 96.43 0.00e+00 1197.00
IUUC-Apl-003259 Anas platyrhynchos 84.62 0.00e+00 1080.00
IUUC-Aca-004983 Anolis carolinensis 82.85 0.00e+00 1034.00
IUUC-Bta-013005 Bos taurus 91.99 0.00e+00 1160.00
IUUC-Cja-019238 Callithrix jacchus 97.89 0.00e+00 1208.00
IUUC-Cfa-020072 Canis familiaris 93.02 0.00e+00 1148.00
IUUC-Cpo-021329 Cavia porcellus 89.39 0.00e+00 1075.00
IUUC-Csa-023691 Chlorocebus sabaeus 99.36 0.00e+00 1237.00
IUUC-Cho-024922 Choloepus hoffmanni 97.44 0.00e+00 731.00
IUUC-Dre-028661 Danio rerio 75.49 0.00e+00 959.00
IUUC-Dno-029076 Dasypus novemcinctus 94.87 0.00e+00 1202.00
IUUC-Dor-031088 Dipodomys ordii 79.13 0.00e+00 934.00
IUUC-Ete-032920 Echinops telfairi 94.22 2.00e-168 585.00
IUUC-Eca-034024 Equus caballus 96.59 0.00e+00 1196.00
IUUC-Eeu-035306 Erinaceus europaeus 90.13 4.00e-127 448.00
IUUC-Fca-036158 Felis catus 96.27 0.00e+00 1191.00
IUUC-Fal-037022 Ficedula albicollis 83.17 0.00e+00 1073.00
IUUC-Gga-040196 Gallus gallus 84.15 0.00e+00 1077.00
IUUC-Gac-041632 Gasterosteus aculeatus 72.91 0.00e+00 959.00
IUUC-Ggo-045013 Gorilla gorilla 98.26 0.00e+00 1218.00
IUUC-Itr-048718 Ictidomys tridecemlineatus 96.43 0.00e+00 1193.00
IUUC-Lch-049472 Latimeria chalumnae 78.58 0.00e+00 980.00
IUUC-Loc-052506 Lepisosteus oculatus 77.13 0.00e+00 999.00
IUUC-Laf-053923 Loxodonta africana 95.94 0.00e+00 1191.00
IUUC-Mcc-054899 Macaca mulatta 99.04 0.00e+00 1236.00
IUUC-Meu-056196 Macropus eugenii 90.00 0.00e+00 922.00
IUUC-Mga-059467 Meleagris gallopavo 84.15 0.00e+00 1079.00
IUUC-Mmr-061561 Microcebus murinus 96.96 0.00e+00 1209.00
IUUC-Mdo-063046 Monodelphis domestica 87.66 0.00e+00 1159.00
IUUC-Mmu-064137 Mus musculus 92.21 0.00e+00 1161.00
IUUC-Mpu-066493 Mustela putorius furo 95.62 0.00e+00 1192.00
IUUC-Mlu-067496 Myotis lucifugus 92.95 0.00e+00 1212.00
IUUC-Nle-069165 Nomascus leucogenys 98.88 0.00e+00 1233.00
IUUC-Opr-071189 Ochotona princeps 96.10 0.00e+00 1202.00
IUUC-Ont-072402 Oreochromis niloticus 73.73 0.00e+00 975.00
IUUC-Oan-073016 Ornithorhynchus anatinus 86.18 0.00e+00 1085.00
IUUC-Ocu-074754 Oryctolagus cuniculus 96.27 0.00e+00 1195.00
IUUC-Oga-088554 Otolemur garnettii 97.24 0.00e+00 1201.00
IUUC-Oar-089224 Ovis aries 92.42 0.00e+00 1127.00
IUUC-Ptr-091386 Pan troglodytes 99.04 0.00e+00 1234.00
IUUC-Pan-091805 Papio anubis 98.72 0.00e+00 1231.00
IUUC-Psi-093677 Pelodiscus sinensis 84.78 0.00e+00 1094.00
IUUC-Pma-094418 Petromyzon marinus 65.07 0.00e+00 844.00
IUUC-Pab-098736 Pongo abelii 99.36 0.00e+00 1234.00
IUUC-Pca-100924 Procavia capensis 94.23 0.00e+00 1193.00
IUUC-Pva-102855 Pteropus vampyrus 95.67 0.00e+00 1243.00
IUUC-Rno-106048 Rattus norvegicus 91.56 0.00e+00 1149.00
IUUC-Sha-106994 Sarcophilus harrisii 87.02 0.00e+00 1152.00
IUUC-Ssc-115520 Sus scrofa 94.55 0.00e+00 1192.00
IUUC-Tgu-116543 Taeniopygia guttata 83.33 0.00e+00 1063.00
IUUC-Tni-120722 Tetraodon nigroviridis 73.52 0.00e+00 919.00
IUUC-Tvi-122419 Trichoderma virens 33.33 1.00e-04 40.00
IUUC-Tbe-127534 Tupaia belangeri 97.12 0.00e+00 1212.00
IUUC-Ttr-128994 Tursiops truncatus 93.91 0.00e+00 1186.00
IUUC-Vpa-130695 Vicugna pacos 96.15 0.00e+00 738.00
IUUC-Xtr-132249 Xenopus tropicalis 80.48 0.00e+00 1011.00
Created Date 25-Jun-2017

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