iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-18	66.6	134	189

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            e+v++l+d++++++++L +kkGd++++   ++ +e W+++ ++ egkrG++P  +vek
   Q: 134  AEYVRALFDFNGNDEEDLPFKKGDILRI--RDKPEEQWWNA-EDSEGKRGMIPVPYVEK 189
           689*************************..6999******9.5**************98 PP

Organism

Rattus norvegicus

Functional Description
(View)

Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Protein Sequence
(Fasta)

MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 60
IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGGAAGGC CCGCGGCTGC CGCCGCCATT TCGGGCGCTG CTGGGAGGCT TACACCGGAG 60
CCGGTCCGCT GGGCGGCGGG CGCCAGGGCT GGAGGGGCGC GCGTGCCGGC GGCGGCCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain

Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045121--C:membrane raft
GO:0005886--C:plasma membrane
GO:0008092--F:cytoskeletal protein binding
GO:0019899--F:enzyme binding
GO:0005159--F:insulin-like growth factor receptor binding
GO:0030674--F:protein binding, bridging
GO:0019904--F:protein domain specific binding
GO:1990782--F:protein tyrosine kinase binding
GO:0097110--F:scaffold protein binding
GO:0007257--P:activation of JUN kinase activity
GO:0000186--P:activation of MAPKK activity
GO:1990859--P:cellular response to endothelin
GO:1990314--P:cellular response to insulin-like growth factor stimulus
GO:1990090--P:cellular response to nerve growth factor stimulus
GO:0071732--P:cellular response to nitric oxide
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0048013--P:ephrin receptor signaling pathway
GO:0045953--P:negative regulation of natural killer cell mediated cytotoxicity
GO:0014911--P:positive regulation of smooth muscle cell migration
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0051270--P:regulation of cellular component movement
GO:0043087--P:regulation of GTPase activity
GO:0035020--P:regulation of Rac protein signal transduction
GO:0035728--P:response to hepatocyte growth factor
GO:0042542--P:response to hydrogen peroxide
GO:1901652--P:response to peptide
GO:0001878--P:response to yeast

KEGG

rno:54245

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001192	Ailuropoda melanoleuca	99.33	4.00e-160	556.00
IUUC-Apl-003225	Anas platyrhynchos	91.56	2.00e-122	431.00
IUUC-Aca-004818	Anolis carolinensis	78.79	2.00e-93	335.00
IUUC-Ame-011721	Astyanax mexicanus	68.04	2.00e-118	418.00
IUUC-Bta-012320	Bos taurus	99.67	2.00e-163	567.00
IUUC-Cel-018307	Caenorhabditis elegans	30.33	3.00e-26	112.00
IUUC-Cja-019935	Callithrix jacchus	96.05	2.00e-167	581.00
IUUC-Cfa-021221	Canis familiaris	99.34	3.00e-163	567.00
IUUC-Cpo-021592	Cavia porcellus	86.49	7.00e-138	483.00
IUUC-Csa-024128	Chlorocebus sabaeus	100.00	6.00e-101	359.00
IUUC-Cho-024775	Choloepus hoffmanni	97.70	1.00e-161	561.00
IUUC-Dre-027390	Danio rerio	69.57	2.00e-120	424.00
IUUC-Dno-029847	Dasypus novemcinctus	99.67	2.00e-163	567.00
IUUC-Dor-030360	Dipodomys ordii	89.47	4.00e-156	543.00
IUUC-Ete-032604	Echinops telfairi	96.41	9.00e-126	442.00
IUUC-Eca-033233	Equus caballus	98.03	9.00e-163	565.00
IUUC-Eeu-034642	Erinaceus europaeus	96.86	1.00e-127	448.00
IUUC-Fca-035955	Felis catus	99.11	6.00e-131	459.00
IUUC-Fal-037152	Ficedula albicollis	86.48	6.00e-141	493.00
IUUC-Gmo-038849	Gadus morhua	68.04	2.00e-118	418.00
IUUC-Gga-040861	Gallus gallus	83.61	6.00e-150	523.00
IUUC-Gac-041627	Gasterosteus aculeatus	66.36	3.00e-120	424.00
IUUC-Ggo-045475	Gorilla gorilla	99.67	2.00e-163	567.00
IUUC-Hsa-046008	Homo sapiens	99.67	2.00e-163	567.00
IUUC-Itr-048906	Ictidomys tridecemlineatus	99.62	2.00e-134	471.00
IUUC-Lch-050509	Latimeria chalumnae	81.61	1.00e-148	519.00
IUUC-Loc-052229	Lepisosteus oculatus	73.53	1.00e-108	385.00
IUUC-Laf-053896	Loxodonta africana	94.79	1.00e-166	578.00
IUUC-Mcc-055280	Macaca mulatta	99.67	2.00e-163	567.00
IUUC-Meu-056783	Macropus eugenii	96.41	2.00e-126	444.00
IUUC-Mga-059345	Meleagris gallopavo	91.93	2.00e-123	434.00
IUUC-Mdo-062691	Monodelphis domestica	87.99	1.00e-153	535.00
IUUC-Mmu-063691	Mus musculus	99.34	5.00e-163	566.00
IUUC-Mpu-065737	Mustela putorius furo	99.34	2.00e-163	567.00
IUUC-Mlu-067005	Myotis lucifugus	96.38	1.00e-158	551.00
IUUC-Nle-070154	Nomascus leucogenys	99.11	9.00e-131	458.00
IUUC-Opr-071114	Ochotona princeps	98.03	2.00e-175	608.00
IUUC-Ont-071696	Oreochromis niloticus	70.06	5.00e-116	410.00
IUUC-Oan-072967	Ornithorhynchus anatinus	93.46	7.00e-133	466.00
IUUC-Ocu-074025	Oryctolagus cuniculus	99.01	2.00e-99	354.00
IUUC-Olo-080293	Oryza longistaminata	40.00	1.80e+00	26.20
IUUC-Ola-087265	Oryzias latipes	67.38	1.00e-95	342.00
IUUC-Oga-088266	Otolemur garnettii	98.36	2.00e-162	564.00
IUUC-Oar-089221	Ovis aries	98.03	1.00e-158	551.00
IUUC-Ptr-091463	Pan troglodytes	95.07	3.00e-151	527.00
IUUC-Pan-092242	Papio anubis	99.34	2.00e-163	567.00
IUUC-Psi-093287	Pelodiscus sinensis	94.20	2.00e-126	444.00
IUUC-Pfo-097378	Poecilia formosa	66.77	4.00e-111	394.00
IUUC-Pab-097823	Pongo abelii	100.00	6.00e-101	359.00
IUUC-Pca-101068	Procavia capensis	99.67	2.00e-163	567.00
IUUC-Ptt-103815	Puccinia triticina	37.93	4.00e-09	55.10
IUUC-Sar-113453	Sorex araneus	84.21	2.00e-146	511.00
IUUC-Tgu-116926	Taeniopygia guttata	86.23	2.00e-149	521.00
IUUC-Tru-118656	Takifugu rubripes	66.57	7.00e-120	423.00
IUUC-Tni-120497	Tetraodon nigroviridis	69.13	2.00e-115	408.00
IUUC-Tbe-127436	Tupaia belangeri	94.74	2.00e-144	504.00
IUUC-Ttr-129109	Tursiops truncatus	99.55	5.00e-130	456.00
IUUC-Vpa-130527	Vicugna pacos	99.34	2.00e-161	560.00
IUUC-Xtr-131808	Xenopus tropicalis	84.92	1.00e-150	525.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence