iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062072

UUCD1 version

UUC-MoD-00090

Ensembl Protein ID

ENSMODP00000007119.2

UniProt Accession

F6QE74; F6QE74_MONDO

Protein Name

Uncharacterized protein

Gene Name

KEAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000005745.3	ENSMODT00000007263.3	ENSMODP00000007119.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	6.40e-17	61.8	76	147
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	6.30e-09	35.0	180	210

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvv....g.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l+v    +   +f ahk+vLa+sS+vF+a+f+++l+e+   + v i+++ p+v++ l++F Yt ++++ 
   Q: 76   CDVTLQVkyedApAAQFMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPKVMERLIEFAYTASISMG 147
           8******66652699**************************98.***********************998875 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N++gi  fA++ +c +L+++a+++i  hF
   Q: 180  PSNAIGIANFAEQIGCAELHQRAREYIYMHF 210
           89****************************9 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MQPVSGHSRG VPCAHSLPLL SQRPGGAGDA VMYATECKAE VTPSQHGNRT FSYTLEDHTK 60
QAFGIMNELR LSQQLCDVTL QVKYEDAPAA QFMAHKVVLA SSSPVFKAMF TNGLREQGME 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGCGAGATT CCAGGCGGTG GCAGTGTTTT TCTAGAGGCT GATGCAGCCA GTGTCTGGGC 60
ATAGCAGGGG TGTTCCCTGT GCCCATTCTC TCCCCCTCCT GTCCCAACGC CCTGGGGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR030563--KEAP1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005884--C:actin filament
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0005654--C:nucleoplasm
GO:0008134--F:transcription factor binding
GO:0071353--P:cellular response to interleukin-4
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0001701--P:in utero embryonic development
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0045604--P:regulation of epidermal cell differentiation

KEGG

mdo:100012710

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001377	Ailuropoda melanoleuca	94.87	0.00e+00	1235.00
IUUC-Aca-005389	Anolis carolinensis	88.18	0.00e+00	1110.00
IUUC-Ame-010749	Astyanax mexicanus	79.59	0.00e+00	979.00
IUUC-Bta-013505	Bos taurus	93.75	0.00e+00	1219.00
IUUC-Cja-018823	Callithrix jacchus	93.27	0.00e+00	1217.00
IUUC-Cfa-021202	Canis familiaris	94.71	0.00e+00	1233.00
IUUC-Cpo-021830	Cavia porcellus	93.20	0.00e+00	820.00
IUUC-Csa-023728	Chlorocebus sabaeus	93.91	0.00e+00	1222.00
IUUC-Cin-025195	Ciona intestinalis	55.86	0.00e+00	681.00
IUUC-Csv-026155	Ciona savignyi	54.29	0.00e+00	627.00
IUUC-Dre-027388	Danio rerio	78.27	0.00e+00	961.00
IUUC-Dno-029066	Dasypus novemcinctus	83.36	0.00e+00	1056.00
IUUC-Dor-030674	Dipodomys ordii	92.94	0.00e+00	822.00
IUUC-Dme-032165	Drosophila melanogaster	50.27	3.00e-163	568.00
IUUC-Ete-032255	Echinops telfairi	89.01	3.00e-94	338.00
IUUC-Eca-034381	Equus caballus	91.45	0.00e+00	1175.00
IUUC-Eeu-034791	Erinaceus europaeus	94.39	0.00e+00	804.00
IUUC-Fca-036067	Felis catus	94.71	0.00e+00	1232.00
IUUC-Gmo-039691	Gadus morhua	78.06	0.00e+00	961.00
IUUC-Gga-040266	Gallus gallus	80.83	0.00e+00	1018.00
IUUC-Gac-041866	Gasterosteus aculeatus	78.47	0.00e+00	972.00
IUUC-Ggo-044719	Gorilla gorilla	94.07	0.00e+00	1222.00
IUUC-Hsa-046255	Homo sapiens	94.07	0.00e+00	1222.00
IUUC-Itr-048457	Ictidomys tridecemlineatus	94.39	0.00e+00	1231.00
IUUC-Lch-049646	Latimeria chalumnae	84.72	0.00e+00	1064.00
IUUC-Loc-052296	Lepisosteus oculatus	57.49	0.00e+00	644.00
IUUC-Laf-054579	Loxodonta africana	95.27	0.00e+00	1221.00
IUUC-Mcc-055315	Macaca mulatta	93.91	0.00e+00	1222.00
IUUC-Meu-056288	Macropus eugenii	92.62	0.00e+00	1195.00
IUUC-Mmr-061639	Microcebus murinus	93.43	0.00e+00	1221.00
IUUC-Mmu-063622	Mus musculus	91.03	0.00e+00	1190.00
IUUC-Mpu-066737	Mustela putorius furo	92.15	0.00e+00	1191.00
IUUC-Mlu-068173	Myotis lucifugus	94.39	0.00e+00	1229.00
IUUC-Nle-069336	Nomascus leucogenys	55.17	8.00e-170	590.00
IUUC-Opr-070432	Ochotona princeps	94.82	0.00e+00	1194.00
IUUC-Ont-072160	Oreochromis niloticus	78.66	0.00e+00	966.00
IUUC-Oan-072691	Ornithorhynchus anatinus	80.98	0.00e+00	988.00
IUUC-Ocu-073798	Oryctolagus cuniculus	93.59	0.00e+00	1225.00
IUUC-Ola-086367	Oryzias latipes	75.38	0.00e+00	927.00
IUUC-Oga-088231	Otolemur garnettii	93.75	0.00e+00	1220.00
IUUC-Oar-089227	Ovis aries	92.47	0.00e+00	1196.00
IUUC-Ptr-091460	Pan troglodytes	94.07	0.00e+00	1222.00
IUUC-Pan-092713	Papio anubis	93.91	0.00e+00	1222.00
IUUC-Ppa-095249	Physcomitrella patens	33.12	5.00e-15	75.50
IUUC-Pfo-096468	Poecilia formosa	79.46	0.00e+00	971.00
IUUC-Pab-098357	Pongo abelii	94.07	0.00e+00	1224.00
IUUC-Pca-100837	Procavia capensis	92.31	0.00e+00	1198.00
IUUC-Pva-103249	Pteropus vampyrus	91.51	0.00e+00	1166.00
IUUC-Rno-106086	Rattus norvegicus	90.06	0.00e+00	1172.00
IUUC-Sha-107245	Sarcophilus harrisii	99.36	0.00e+00	1304.00
IUUC-Sar-112985	Sorex araneus	94.08	0.00e+00	1204.00
IUUC-Ssc-115756	Sus scrofa	94.71	0.00e+00	1232.00
IUUC-Tgu-116838	Taeniopygia guttata	54.19	6.00e-119	420.00
IUUC-Tru-117644	Takifugu rubripes	77.61	0.00e+00	986.00
IUUC-Tni-120245	Tetraodon nigroviridis	78.88	0.00e+00	976.00
IUUC-Tbe-127472	Tupaia belangeri	95.10	6.00e-145	507.00
IUUC-Ttr-128953	Tursiops truncatus	93.02	0.00e+00	676.00
IUUC-Vpa-130683	Vicugna pacos	94.24	0.00e+00	1086.00
IUUC-Xtr-132827	Xenopus tropicalis	77.44	0.00e+00	966.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence