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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046951
Ensembl Protein ID ENSP00000372394.3
UniProt Accession A0AVI4; A6NH49; A6NI98; D3DVP8; TM129_HUMAN
Genbank Protein ID EAW82569.1; EAW82570.1; EAW82571.1; AAI26371.1
Protein Name E3 ubiquitin-protein ligase TM129; RING-type E3 ubiquitin transferase TM129
Genbank Nucleotide ID AC016773; CH471131; CH471131; BC009331
Gene Name TMEM129
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000168936.10 ENST00000303277.6 ENSP00000305243.2
ENSG00000168936.10 ENST00000382936.7 ENSP00000372394.3
ENSG00000168936.10 ENST00000460722.1 ENSP00000417412.1
ENSG00000168936.10 ENST00000480360.1 ENSP00000417259.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDHINTMenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 24807418
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.
 E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.
Protein Sequence
(Fasta)
MDSPEVTFTL AYLVFAVCFV FTPNEFHAAG LTVQNLLSGW LGSEDAAFVP FHLRRTAATL 60
LCHSLLPLGY YVGMCLAASE KRLHALSQAP EAWRLFLLLA VTLPSIACIL IYYWSRDRWA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046951|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
CGGTTCCGTT TCCGGAGTGG AGGGCACGCC AGGGTGTCTG AAGCTGAGAC CCCGGGCTCG 60
CAGTCGCCCC ATGAATTTCG AGTTCCGCAA CTGACGCTAC TGGGCGGGGC TTCATGGCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046951|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR018801--Tmpp129
Pfam

PF10272--Tmpp129
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0046872--F:metal ion binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0000209--P:protein polyubiquitination
GO:0006986--P:response to unfolded protein
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:92305
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001914 Ailuropoda melanoleuca 91.41 0.00e+00 678.00
IUUC-Apl-003347 Anas platyrhynchos 75.21 1.00e-158 552.00
IUUC-Ame-010846 Astyanax mexicanus 64.99 1.00e-143 502.00
IUUC-Bta-012669 Bos taurus 90.61 0.00e+00 678.00
IUUC-Cel-018636 Caenorhabditis elegans 27.57 1.00e-15 77.80
IUUC-Cja-019250 Callithrix jacchus 93.09 0.00e+00 692.00
IUUC-Cfa-020230 Canis familiaris 91.16 0.00e+00 680.00
IUUC-Cpo-022023 Cavia porcellus 90.61 0.00e+00 675.00
IUUC-Csa-023823 Chlorocebus sabaeus 95.58 0.00e+00 706.00
IUUC-Cin-025745 Ciona intestinalis 41.87 6.00e-86 311.00
IUUC-Csv-025856 Ciona savignyi 42.23 4.00e-87 315.00
IUUC-Dre-028722 Danio rerio 64.64 2.00e-145 508.00
IUUC-Dno-029635 Dasypus novemcinctus 85.86 2.00e-142 498.00
IUUC-Dor-030657 Dipodomys ordii 91.16 0.00e+00 667.00
IUUC-Dme-031679 Drosophila melanogaster 30.87 5.00e-60 224.00
IUUC-Ete-032708 Echinops telfairi 85.40 1.00e-113 401.00
IUUC-Eca-033244 Equus caballus 91.50 2.00e-159 554.00
IUUC-Fca-035762 Felis catus 91.99 0.00e+00 684.00
IUUC-Fal-036939 Ficedula albicollis 75.97 4.00e-166 577.00
IUUC-Fox-038018 Fusarium oxysporum 34.00 1.60e-01 30.80
IUUC-Gmo-039282 Gadus morhua 64.71 3.00e-100 358.00
IUUC-Gga-040148 Gallus gallus 75.41 2.00e-165 574.00
IUUC-Gac-042319 Gasterosteus aculeatus 61.68 8.00e-136 476.00
IUUC-Itr-048030 Ictidomys tridecemlineatus 91.99 0.00e+00 688.00
IUUC-Lch-050659 Latimeria chalumnae 72.98 1.00e-163 568.00
IUUC-Loc-052168 Lepisosteus oculatus 71.55 1.00e-162 566.00
IUUC-Laf-054003 Loxodonta africana 90.06 0.00e+00 674.00
IUUC-Mcc-055211 Macaca mulatta 95.03 0.00e+00 704.00
IUUC-Mtr-057694 Medicago truncatula 45.24 5.10e-02 33.10
IUUC-Mga-059834 Meleagris gallopavo 74.50 2.00e-133 468.00
IUUC-Mdo-062514 Monodelphis domestica 80.89 0.00e+00 629.00
IUUC-Mmu-063651 Mus musculus 89.23 0.00e+00 640.00
IUUC-Mpu-066843 Mustela putorius furo 91.99 0.00e+00 686.00
IUUC-Mlu-067390 Myotis lucifugus 85.05 2.00e-101 361.00
IUUC-Nle-069501 Nomascus leucogenys 98.00 1.00e-175 608.00
IUUC-Ont-071406 Oreochromis niloticus 62.13 3.00e-135 474.00
IUUC-Oan-073199 Ornithorhynchus anatinus 75.14 3.00e-151 527.00
IUUC-Ome-081123 Oryza meridionalis 26.67 7.40e-02 32.30
IUUC-Ola-086495 Oryzias latipes 61.64 3.00e-134 471.00
IUUC-Oga-087914 Otolemur garnettii 92.54 0.00e+00 691.00
IUUC-Oar-089585 Ovis aries 70.37 1.00e-112 399.00
IUUC-Ptr-090660 Pan troglodytes 100.00 3.00e-175 607.00
IUUC-Pan-092206 Papio anubis 95.58 0.00e+00 707.00
IUUC-Psi-093829 Pelodiscus sinensis 76.90 4.00e-168 583.00
IUUC-Pma-094399 Petromyzon marinus 61.26 5.00e-131 460.00
IUUC-Pfo-096826 Poecilia formosa 60.27 8.00e-132 463.00
IUUC-Pab-097827 Pongo abelii 98.62 0.00e+00 734.00
IUUC-Pca-100182 Procavia capensis 90.33 0.00e+00 653.00
IUUC-Pva-103236 Pteropus vampyrus 83.93 2.00e-50 192.00
IUUC-Rno-105429 Rattus norvegicus 89.78 0.00e+00 653.00
IUUC-Sha-107104 Sarcophilus harrisii 79.19 3.00e-146 510.00
IUUC-Ssc-116316 Sus scrofa 90.61 5.00e-179 620.00
IUUC-Tgu-116563 Taeniopygia guttata 75.41 4.00e-165 573.00
IUUC-Tbe-127698 Tupaia belangeri 92.49 4.00e-160 556.00
IUUC-Ttr-128759 Tursiops truncatus 88.12 0.00e+00 640.00
IUUC-Xtr-132390 Xenopus tropicalis 74.86 9.00e-169 586.00
Created Date 25-Jun-2017

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