iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011544

Ensembl Protein ID

ENSAMXP00000018450.1

UniProt Accession

W5LF38; W5LF38_ASTMX

Genbank Protein ID

ENSAMXP00000018450

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

APWO01001318

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000017906.1	ENSAMXT00000018450.1	ENSAMXP00000018450.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-99	333.2	158	509
UBD/ZnF/ZnF_UBP	4.20e-25	88.0	27	104

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+L nipe+ +++++             ++  + +++ +++ +l+++l+k + +lw+++++a+sp +l+ +++
   Q: 158  TGLRNLGNTCFMNAILQSLRNIPEFSCYFKDlpavalrsgktAGRRMYHTRSQGDTSVSLVEELRKTLCSLWQGNQTAFSPDALFYVIW 246
           7******************************888888777664444445555588999******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Efl++lld+l++e++ +kn     +  +d +  + ++ +   + ++++++ +F g l++++ cl c+++s +++
   Q: 247  KIMPSFRGYQQQDAHEFLRYLLDHLHREMQGSKNGLPGPSLLSD-RPNPTSEGKCCINGTPTVVTSVFSGVLQNEVNCLICGTESRKFD 334
           *****************************665554444444444.55666678999999****************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++   k +         +l +cL sft  eel++ + y c kckk+q+++kk++++klP+vL+lhLkRf++  +   r+
   Q: 335  PFLDLSLDIPSQFRVKRTkdqepgptcNLYHCLLSFTDLEELDETELYMCHKCKKRQKSTKKFWVQKLPKVLCLHLKRFHW--TAFLRN 421
           **********77655555778899999****************************************************77..558*** PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld+++f+ +pe++  e+  Y+L avvvH+G +++sGHY+ay  + +g+W++f+Ds+Vt v+ee+v +   ++aY+lf
   Q: 422  KVDTYVEFPLRgLDMKRFLLEPENSLPESGLYNLAAVVVHHGsGVGSGHYTAYGLH-EGRWYHFNDSTVTLVSEETVTK---AKAYILF 506
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y++
   Q: 507  YTE 509
           *97 PP

UBD/ZnF/ZnF_UBP

   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc +v+CGRyv+gHa+kH+e+ q p+                ++++s++s++cY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLTCLNVHCGRYVNGHAKKHFEDIQSPVsgqkkpekeriqqhsvCMDCSSYSTFCYRCDDFVVN 104
           9***************************************************************************85 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MECPHLGSSV CVAVDPARLP SGSPSSWCCS VCRSNKSPWV CLTCLNVHCG RYVNGHAKKH 60
FEDIQSPVSG QKKPEKERIQ QHSVCMDCSS YSTFCYRCDD FVVNDTKLGQ VQRVREHLQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAATTAGT AAGTAAAAGT TAGTTTCCTT TTTCTTTCTT TTTTTTGGGC TAATTATGTT 60
GTTATTAAAT GTTCTTGACT GGTATATAAA ACTGTTATTT TTAAATTGTG TTAATGGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	76.60	0.00e+00	772.00
IUUC-Apl-003358	Anas platyrhynchos	77.41	0.00e+00	699.00
IUUC-Aca-004454	Anolis carolinensis	77.15	0.00e+00	697.00
IUUC-Aor-010035	Aspergillus oryzae	35.55	1.00e-36	146.00
IUUC-Bta-012738	Bos taurus	77.03	0.00e+00	735.00
IUUC-Cel-018186	Caenorhabditis elegans	36.57	6.00e-60	225.00
IUUC-Cja-018893	Callithrix jacchus	76.79	0.00e+00	729.00
IUUC-Cfa-020607	Canis familiaris	76.98	0.00e+00	736.00
IUUC-Cpo-021828	Cavia porcellus	77.56	0.00e+00	737.00
IUUC-Csa-023884	Chlorocebus sabaeus	77.25	4.00e-169	587.00
IUUC-Cho-024863	Choloepus hoffmanni	68.86	0.00e+00	632.00
IUUC-Dre-028452	Danio rerio	82.50	0.00e+00	845.00
IUUC-Dno-029531	Dasypus novemcinctus	77.00	0.00e+00	680.00
IUUC-Dor-030913	Dipodomys ordii	69.67	1.00e-139	489.00
IUUC-Ete-032611	Echinops telfairi	72.96	0.00e+00	699.00
IUUC-Eca-033622	Equus caballus	77.00	0.00e+00	685.00
IUUC-Eeu-035268	Erinaceus europaeus	74.07	0.00e+00	632.00
IUUC-Fca-035801	Felis catus	76.80	0.00e+00	691.00
IUUC-Fal-036749	Ficedula albicollis	77.80	0.00e+00	690.00
IUUC-Gmo-039598	Gadus morhua	79.22	0.00e+00	800.00
IUUC-Gga-040883	Gallus gallus	77.62	0.00e+00	690.00
IUUC-Gac-042235	Gasterosteus aculeatus	76.36	0.00e+00	758.00
IUUC-Ggo-044767	Gorilla gorilla	73.36	0.00e+00	645.00
IUUC-Hsa-046581	Homo sapiens	76.79	0.00e+00	746.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	76.98	0.00e+00	736.00
IUUC-Lch-049732	Latimeria chalumnae	77.34	0.00e+00	770.00
IUUC-Loc-052371	Lepisosteus oculatus	78.95	0.00e+00	788.00
IUUC-Laf-054565	Loxodonta africana	77.18	0.00e+00	736.00
IUUC-Mcc-055522	Macaca mulatta	76.98	0.00e+00	748.00
IUUC-Meu-056754	Macropus eugenii	68.04	4.00e-138	484.00
IUUC-Mga-060095	Meleagris gallopavo	73.21	8.00e-146	509.00
IUUC-Mmr-060839	Microcebus murinus	76.98	0.00e+00	736.00
IUUC-Mdo-062339	Monodelphis domestica	77.78	2.00e-172	598.00
IUUC-Mmu-063638	Mus musculus	76.52	0.00e+00	716.00
IUUC-Mpu-066647	Mustela putorius furo	77.55	4.00e-172	597.00
IUUC-Mlu-067921	Myotis lucifugus	75.56	0.00e+00	702.00
IUUC-Nle-069752	Nomascus leucogenys	76.98	0.00e+00	748.00
IUUC-Opr-070636	Ochotona princeps	68.09	3.00e-169	588.00
IUUC-Ont-071638	Oreochromis niloticus	78.56	0.00e+00	721.00
IUUC-Oan-073417	Ornithorhynchus anatinus	72.92	0.00e+00	696.00
IUUC-Ocu-074620	Oryctolagus cuniculus	77.37	0.00e+00	740.00
IUUC-Ola-087281	Oryzias latipes	79.21	0.00e+00	642.00
IUUC-Olu-087697	Ostreococcus lucimarinus	38.02	1.00e-50	192.00
IUUC-Oga-088448	Otolemur garnettii	76.98	0.00e+00	744.00
IUUC-Oar-090132	Ovis aries	76.98	0.00e+00	738.00
IUUC-Ptr-090696	Pan troglodytes	76.84	0.00e+00	697.00
IUUC-Pan-092124	Papio anubis	76.79	0.00e+00	745.00
IUUC-Psi-093801	Pelodiscus sinensis	77.78	1.00e-171	595.00
IUUC-Pma-094472	Petromyzon marinus	69.43	3.00e-89	320.00
IUUC-Pfo-096330	Poecilia formosa	77.48	0.00e+00	788.00
IUUC-Pab-098191	Pongo abelii	76.98	0.00e+00	748.00
IUUC-Pca-100341	Procavia capensis	66.34	0.00e+00	626.00
IUUC-Pva-103177	Pteropus vampyrus	76.74	0.00e+00	731.00
IUUC-Rno-105048	Rattus norvegicus	75.83	0.00e+00	705.00
IUUC-Sha-107429	Sarcophilus harrisii	76.52	0.00e+00	686.00
IUUC-Sar-113024	Sorex araneus	77.25	0.00e+00	646.00
IUUC-Ssc-115749	Sus scrofa	72.04	8.00e-117	412.00
IUUC-Tgu-117277	Taeniopygia guttata	77.48	0.00e+00	694.00
IUUC-Tru-117844	Takifugu rubripes	77.69	0.00e+00	783.00
IUUC-Tsy-119456	Tarsius syrichta	74.90	0.00e+00	685.00
IUUC-Tni-120251	Tetraodon nigroviridis	75.34	0.00e+00	811.00
IUUC-Tbe-127423	Tupaia belangeri	72.92	0.00e+00	679.00
IUUC-Ttr-128401	Tursiops truncatus	71.60	2.00e-178	618.00
IUUC-Vpa-130549	Vicugna pacos	65.77	6.00e-126	443.00
IUUC-Xtr-131892	Xenopus tropicalis	70.92	0.00e+00	664.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence