iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	miRTarBase	microRNA
TRANSFAC	RepTar	RAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
CPLM	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.30e-135	450.8	642	973

Active Site

Position(s)	Description	Evidence
943	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 642  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 730
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 731  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 814
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 815  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 903
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 904  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 973
           *********************************************************************8 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MATGLGEPVY GLSEEEGESR ILRVKVVSGI DLAKKDIFGA SDPYVKLSLY VADENRELAL 60
VQTKTIKKTL NPKWNEEFYF RVNPSNHRLL FEVFDENRLT RDDFLGQVDV PLSHLPTEDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGATCGCCGA GCGGGCTTGG GGAGGCCGGG AGAGCCATCG GCGGGGGCGG GAGCCCGGCG 60
GGCTCAGCGC AGAGCAGGGA GAGCTCCGGG CCAGTCGCCG TTCGGCGCGC TCTCGGGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0045732--P:positive regulation of protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

KEGG

mmu:83814

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	95.02	0.00e+00	1696.00
IUUC-Apl-003893	Anas platyrhynchos	94.06	0.00e+00	1702.00
IUUC-Aca-004744	Anolis carolinensis	90.48	0.00e+00	1656.00
IUUC-Acl-008273	Aspergillus clavatus	49.26	1.00e-163	570.00
IUUC-Afl-008713	Aspergillus flavus	49.01	3.00e-161	562.00
IUUC-Afu-009103	Aspergillus fumigatus	49.02	7.00e-164	571.00
IUUC-Ani-009259	Aspergillus nidulans	49.16	1.00e-161	563.00
IUUC-Ang-009738	Aspergillus niger	49.33	4.00e-162	565.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	1.00e-101	362.00
IUUC-Ate-010529	Aspergillus terreus	49.42	2.00e-164	573.00
IUUC-Ame-010810	Astyanax mexicanus	72.25	0.00e+00	1259.00
IUUC-Bgr-012148	Blumeria graminis	47.91	1.00e-154	540.00
IUUC-Bta-012679	Bos taurus	96.81	0.00e+00	1602.00
IUUC-Bci-013785	Botrytis cinerea	47.99	3.00e-156	545.00
IUUC-Cel-018564	Caenorhabditis elegans	52.36	0.00e+00	632.00
IUUC-Cja-018732	Callithrix jacchus	97.85	0.00e+00	1833.00
IUUC-Cfa-021226	Canis familiaris	97.19	0.00e+00	1799.00
IUUC-Cpo-021671	Cavia porcellus	95.95	0.00e+00	1753.00
IUUC-Csa-023344	Chlorocebus sabaeus	95.98	0.00e+00	1816.00
IUUC-Cho-024832	Choloepus hoffmanni	100.00	0.00e+00	744.00
IUUC-Csv-026098	Ciona savignyi	59.22	0.00e+00	655.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.66	1.00e-155	543.00
IUUC-Cne-026849	Cryptococcus neoformans	48.58	1.00e-158	553.00
IUUC-Dre-027770	Danio rerio	78.54	0.00e+00	1435.00
IUUC-Dno-029466	Dasypus novemcinctus	98.36	0.00e+00	1847.00
IUUC-Dor-030138	Dipodomys ordii	92.41	0.00e+00	1640.00
IUUC-Dse-031241	Dothistroma septosporum	47.86	2.00e-160	559.00
IUUC-Dme-032166	Drosophila melanogaster	67.09	0.00e+00	713.00
IUUC-Ete-033145	Echinops telfairi	88.79	0.00e+00	1283.00
IUUC-Eca-033445	Equus caballus	97.38	0.00e+00	1590.00
IUUC-Eeu-035247	Erinaceus europaeus	88.27	0.00e+00	1491.00
IUUC-Fca-035489	Felis catus	93.90	0.00e+00	1538.00
IUUC-Fal-037604	Ficedula albicollis	91.19	0.00e+00	1710.00
IUUC-Fox-037774	Fusarium oxysporum	48.76	4.00e-159	555.00
IUUC-Fso-038393	Fusarium solani	47.41	5.00e-154	538.00
IUUC-Gmo-039674	Gadus morhua	76.57	0.00e+00	1398.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.75	4.00e-156	545.00
IUUC-Gga-040703	Gallus gallus	93.34	0.00e+00	1759.00
IUUC-Gac-042020	Gasterosteus aculeatus	80.47	0.00e+00	1434.00
IUUC-Ggo-045332	Gorilla gorilla	95.95	0.00e+00	1731.00
IUUC-Hsa-045968	Homo sapiens	97.85	0.00e+00	1830.00
IUUC-Lch-050443	Latimeria chalumnae	86.76	0.00e+00	1437.00
IUUC-Loc-052662	Lepisosteus oculatus	80.24	0.00e+00	1451.00
IUUC-Laf-053850	Loxodonta africana	96.36	0.00e+00	1780.00
IUUC-Mcc-055821	Macaca mulatta	97.71	0.00e+00	1793.00
IUUC-Meu-056712	Macropus eugenii	81.44	0.00e+00	769.00
IUUC-Mor-057097	Magnaporthe oryzae	44.54	2.00e-157	549.00
IUUC-Mpo-057442	Magnaporthe poae	52.16	1.00e-145	511.00
IUUC-Mvi-060395	Microbotryum violaceum	53.70	3.00e-150	526.00
IUUC-Mmr-060798	Microcebus murinus	93.98	0.00e+00	1674.00
IUUC-Mdo-062173	Monodelphis domestica	94.97	0.00e+00	1822.00
IUUC-Mpu-066765	Mustela putorius furo	97.29	0.00e+00	1779.00
IUUC-Mlu-067565	Myotis lucifugus	94.89	0.00e+00	1571.00
IUUC-Nfi-068427	Neosartorya fischeri	49.02	5.00e-164	571.00
IUUC-Ncr-068918	Neurospora crassa	47.57	9.00e-158	550.00
IUUC-Nle-069070	Nomascus leucogenys	93.96	0.00e+00	1734.00
IUUC-Opr-071044	Ochotona princeps	96.28	0.00e+00	1202.00
IUUC-Ont-072044	Oreochromis niloticus	77.89	0.00e+00	1462.00
IUUC-Oan-073032	Ornithorhynchus anatinus	92.53	0.00e+00	1442.00
IUUC-Ocu-074160	Oryctolagus cuniculus	94.28	0.00e+00	1725.00
IUUC-Ola-087467	Oryzias latipes	79.67	0.00e+00	1451.00
IUUC-Oga-088460	Otolemur garnettii	93.17	0.00e+00	1568.00
IUUC-Oar-090198	Ovis aries	96.67	0.00e+00	1766.00
IUUC-Ptr-090939	Pan troglodytes	97.85	0.00e+00	1830.00
IUUC-Pan-092284	Papio anubis	97.95	0.00e+00	1833.00
IUUC-Psi-093645	Pelodiscus sinensis	93.44	0.00e+00	1752.00
IUUC-Pma-094364	Petromyzon marinus	82.63	0.00e+00	863.00
IUUC-Pno-095118	Phaeosphaeria nodorum	48.32	4.00e-165	575.00
IUUC-Pfo-097145	Poecilia formosa	61.68	0.00e+00	1129.00
IUUC-Pab-098088	Pongo abelii	97.62	0.00e+00	1803.00
IUUC-Pca-100714	Procavia capensis	75.47	0.00e+00	1310.00
IUUC-Pva-102354	Pteropus vampyrus	95.40	0.00e+00	1692.00
IUUC-Pgr-103620	Puccinia graminis	53.53	3.00e-148	518.00
IUUC-Ptt-103806	Puccinia triticina	53.38	7.00e-123	434.00
IUUC-Pte-104016	Pyrenophora teres	49.00	3.00e-162	565.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.00	3.00e-162	565.00
IUUC-Rno-105318	Rattus norvegicus	98.54	0.00e+00	1774.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.25	3.00e-164	572.00
IUUC-Sha-107482	Sarcophilus harrisii	96.37	0.00e+00	1620.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	54.23	2.00e-150	526.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	48.49	4.00e-158	551.00
IUUC-Ssc-115950	Sus scrofa	70.93	0.00e+00	1182.00
IUUC-Tgu-117130	Taeniopygia guttata	94.37	0.00e+00	1739.00
IUUC-Tru-118610	Takifugu rubripes	80.35	0.00e+00	1477.00
IUUC-Tsy-119492	Tarsius syrichta	91.95	0.00e+00	1642.00
IUUC-Tni-120113	Tetraodon nigroviridis	75.23	0.00e+00	1353.00
IUUC-Tre-122203	Trichoderma reesei	47.61	3.00e-152	532.00
IUUC-Tvi-122595	Trichoderma virens	47.44	8.00e-155	541.00
IUUC-Tbe-127441	Tupaia belangeri	89.66	0.00e+00	790.00
IUUC-Ttr-128235	Tursiops truncatus	99.28	0.00e+00	1089.00
IUUC-Vda-129753	Verticillium dahliae	47.85	3.00e-157	548.00
IUUC-Xtr-132859	Xenopus tropicalis	89.74	0.00e+00	1668.00
IUUC-Xma-133797	Xiphophorus maculatus	80.93	0.00e+00	1466.00
IUUC-Yli-134668	Yarrowia lipolytica	46.42	3.00e-162	565.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence