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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046390
Ensembl Protein ID ENSP00000374455.4
UniProt Accession Q13501; A6NFN7; B2R661; B3KUW5; Q13446; Q9BUV7; Q9BVS6; Q9UEU1; SQSTM_HUMAN
Genbank Protein ID AAA93299.1; AAC52070.1; BAG53577.1; BAG35358.1; AAH00951.1; AAH01874.1; AAH03139.1; AAH17222.1; AAH19111.1; AAC64516.1
Protein Name Sequestosome-1; EBI3-associated protein of 60 kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; Ubiquitin-binding protein p62
Genbank Nucleotide ID U41806; U46751; AK098077; AK312451; AC008393; BC001874; BC003139; BC017222; BC019111; AF060494
Gene Name SQSTM1; ORCA; OSIL
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000161011.19 ENST00000389805.8 ENSP00000374455.4
ENSG00000161011.19 ENST00000453046.5 ENSP00000405061.1
ENSG00000161011.19 ENST00000504627.1 ENSP00000425957.1
ENSG00000161011.19 ENST00000510187.5 ENSP00000424477.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Drug and target
TTDManually
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 15340068; 15493999; 15765181; 15911346; 15964033; 16691492; 16877352; 17052185; 17181397; 17229006; 17296612; 17685470; 23117207; 24642144
ULD/UDP/UFD/PB1 PB1 16949360
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 0.0011 20.7 396 430
ULD/UDP/UFD/PB1 7.80e-18 66.1 22 102
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 5    dkleqlveMGF.dreealqaLraa.nnnleaAvey 37
           + l q+ +MGF d+  +l+ L+++ n+++ aA++ 
   Q: 396  ESLSQMLSMGFsDEGGWLTRLLQTkNYDIGAALDT 430
           6799*******6666*****************985 PP
   

   ULD/UDP/UFD/PB1
   S: 3    rvkvsykgeirsfaldlekpgkfedLlkavrt.ltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqkk 84
           r+ +++++e+++ a+++++pg +e+Ll++v++ +++l+   ++ +Y+DedGDlv+++sDe+l++a+s+   k++++r++i++k
   Q: 22   RFSFCCSPEPEAEAEAAAGPGPCERLLSRVAAlFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSY--VKDDIFRIYIKEK 102
           899*****************************999********************************7..9*********975 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
 Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
Protein Sequence
(Fasta)
MASLTVKAYL LGKEDAAREI RRFSFCCSPE PEAEAEAAAG PGPCERLLSR VAALFPALRP 60
GGFQAHYRDE DGDLVAFSSD EELTMAMSYV KDDIFRIYIK EKKECRRDHR PPCAQEAPRN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046390|UBD,UBA;ULD,PB1|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGGCCGCCT TCCGCGGCCA CCGCCGGGCC CGCTCCCGCC GCCGACGCCC AGGTGCGCCA 60
GGTGCGGGCC GGGCGGGGGT CGCGCTCACC TTTCTGGCCG CTGAGTGCCG CGTACCAGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046390|UBD,UBA;ULD,PB1|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0036--Amyotrophic lateral sclerosis
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0221--Differentiation
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0391--Immunity
KW-0458--Lysosome
KW-0479--Metal-binding
KW-0523--Neurodegeneration
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000270--PB1_dom
IPR033741--SQSTM_UBA
IPR015940--UBA
IPR009060--UBA-like
IPR000433--Znf_ZZ
PROSITE

PS51745--PB1
PS50030--UBA
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF00564--PB1
PF16577--UBA_5
PF00569--ZZ
SMART

SM00666--PB1
SM00165--UBA
SM00291--ZnF_ZZ
Gene Ontology

GO:0016235--C:aggresome
GO:0044753--C:amphisome
GO:0044754--C:autolysosome
GO:0005776--C:autophagosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0016234--C:inclusion body
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0016605--C:PML body
GO:0000407--C:pre-autophagosomal structure
GO:0097225--C:sperm midpiece
GO:0042802--F:identical protein binding
GO:0019901--F:protein kinase binding
GO:0005080--F:protein kinase C binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0030971--F:receptor tyrosine kinase binding
GO:0042169--F:SH2 domain binding
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0006914--P:autophagy
GO:0030154--P:cell differentiation
GO:0016197--P:endosomal transport
GO:0002376--P:immune system process
GO:0035556--P:intracellular signal transduction
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0043066--P:negative regulation of apoptotic process
GO:0044130--P:negative regulation of growth of symbiont in host
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0043065--P:positive regulation of apoptotic process
GO:0016239--P:positive regulation of macroautophagy
GO:0098779--P:positive regulation of macromitophagy in response to mitochondrial depolarization
GO:0001934--P:positive regulation of protein phosphorylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0051291--P:protein heterooligomerization
GO:0008104--P:protein localization
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0010821--P:regulation of mitochondrion organization
GO:0061635--P:regulation of protein complex stability
GO:0046578--P:regulation of Ras protein signal transduction
GO:0006950--P:response to stress
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:8878
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001367 Ailuropoda melanoleuca 90.86 1.00e-169 588.00
IUUC-Apl-003897 Anas platyrhynchos 59.06 5.00e-116 410.00
IUUC-Aca-004699 Anolis carolinensis 47.81 1.00e-94 340.00
IUUC-Ame-010982 Astyanax mexicanus 45.37 1.00e-65 243.00
IUUC-Bta-012634 Bos taurus 92.05 0.00e+00 750.00
IUUC-Cel-018660 Caenorhabditis elegans 50.00 1.00e-10 59.70
IUUC-Cja-019684 Callithrix jacchus 94.55 0.00e+00 754.00
IUUC-Cfa-020573 Canis familiaris 84.66 3.00e-136 478.00
IUUC-Cpo-021425 Cavia porcellus 79.50 8.00e-175 606.00
IUUC-Csa-023968 Chlorocebus sabaeus 96.59 0.00e+00 750.00
IUUC-Cho-024596 Choloepus hoffmanni 85.81 2.00e-51 196.00
IUUC-Cin-025557 Ciona intestinalis 34.15 2.00e-12 67.00
IUUC-Csv-025974 Ciona savignyi 25.77 7.00e-13 68.20
IUUC-Dre-028621 Danio rerio 43.91 4.00e-95 341.00
IUUC-Dno-029060 Dasypus novemcinctus 88.51 0.00e+00 727.00
IUUC-Dor-030547 Dipodomys ordii 89.38 3.00e-135 475.00
IUUC-Ete-033201 Echinops telfairi 79.36 9.00e-163 566.00
IUUC-Eca-033456 Equus caballus 90.86 0.00e+00 676.00
IUUC-Eeu-035157 Erinaceus europaeus 81.28 1.00e-170 592.00
IUUC-Fca-035403 Felis catus 90.54 0.00e+00 703.00
IUUC-Fal-036798 Ficedula albicollis 57.14 9.00e-134 470.00
IUUC-Gmo-039619 Gadus morhua 40.96 2.00e-47 182.00
IUUC-Gga-040137 Gallus gallus 57.78 7.00e-133 467.00
IUUC-Gac-042410 Gasterosteus aculeatus 45.39 3.00e-95 342.00
IUUC-Ggo-044690 Gorilla gorilla 99.32 0.00e+00 764.00
IUUC-Itr-048536 Ictidomys tridecemlineatus 93.41 0.00e+00 773.00
IUUC-Lch-049658 Latimeria chalumnae 47.29 5.00e-110 391.00
IUUC-Loc-052589 Lepisosteus oculatus 47.70 2.00e-109 389.00
IUUC-Laf-053746 Loxodonta africana 82.29 0.00e+00 644.00
IUUC-Mcc-055635 Macaca mulatta 95.68 0.00e+00 765.00
IUUC-Meu-056528 Macropus eugenii 51.00 2.00e-100 358.00
IUUC-Mga-059458 Meleagris gallopavo 59.65 1.00e-118 419.00
IUUC-Mvi-060347 Microbotryum violaceum 54.05 2.00e-07 52.40
IUUC-Mmr-061539 Microcebus murinus 90.85 8.00e-140 489.00
IUUC-Mdo-063083 Monodelphis domestica 64.98 8.00e-150 523.00
IUUC-Mmu-063589 Mus musculus 89.14 0.00e+00 741.00
IUUC-Mpu-065727 Mustela putorius furo 89.22 8.00e-180 622.00
IUUC-Mlu-067026 Myotis lucifugus 88.00 0.00e+00 630.00
IUUC-Nle-069356 Nomascus leucogenys 68.83 6.00e-129 454.00
IUUC-Opr-071091 Ochotona princeps 71.00 2.00e-94 339.00
IUUC-Ont-071864 Oreochromis niloticus 46.97 1.00e-101 363.00
IUUC-Oan-073308 Ornithorhynchus anatinus 64.52 3.00e-136 478.00
IUUC-Ocu-074110 Oryctolagus cuniculus 92.05 0.00e+00 735.00
IUUC-Ola-086944 Oryzias latipes 45.25 2.00e-40 158.00
IUUC-Oga-088869 Otolemur garnettii 91.93 0.00e+00 744.00
IUUC-Oar-089857 Ovis aries 93.07 0.00e+00 659.00
IUUC-Ptr-091640 Pan troglodytes 99.77 0.00e+00 766.00
IUUC-Pan-092831 Papio anubis 96.64 0.00e+00 755.00
IUUC-Psi-093925 Pelodiscus sinensis 56.32 4.00e-125 441.00
IUUC-Pma-094576 Petromyzon marinus 30.95 9.00e-30 124.00
IUUC-Pfo-097297 Poecilia formosa 43.68 1.00e-89 323.00
IUUC-Pab-098725 Pongo abelii 87.05 0.00e+00 665.00
IUUC-Pca-101106 Procavia capensis 91.14 0.00e+00 714.00
IUUC-Pva-102710 Pteropus vampyrus 88.21 0.00e+00 640.00
IUUC-Rno-105539 Rattus norvegicus 89.14 0.00e+00 744.00
IUUC-Sha-107469 Sarcophilus harrisii 61.08 9.00e-122 430.00
IUUC-Ssc-115526 Sus scrofa 92.95 0.00e+00 730.00
IUUC-Tgu-117194 Taeniopygia guttata 60.31 3.00e-117 414.00
IUUC-Tru-117896 Takifugu rubripes 47.87 2.00e-100 359.00
IUUC-Tni-119943 Tetraodon nigroviridis 47.35 2.00e-89 322.00
IUUC-Ttr-128676 Tursiops truncatus 92.27 0.00e+00 752.00
IUUC-Vda-129812 Verticillium dahliae 40.26 6.00e-08 52.80
IUUC-Vpa-130319 Vicugna pacos 96.00 1.00e-56 213.00
IUUC-Xtr-132907 Xenopus tropicalis 53.81 2.00e-126 445.00
Created Date 25-Jun-2017

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