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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046031
UUCD1 version UUC-HoS-00163
Ensembl Protein ID ENSP00000300747.5
UniProt Accession Q6AZZ1; A6NI19; A8K551; B3KPM5; B4DVK4; Q8WZ70; Q96LE5; Q96PF7; Q9H9C2; Q9NW18; TRI68_HUMAN
Genbank Protein ID AAL11501.1; AAL31641.1; BAA91569.1; BAB14309.1; BAF83855.1; BAG62716.1; BAG51737.1; EAW68835.1; AAH75058.1; AAI09064.1; AAF91075.1
Protein Name E3 ubiquitin-protein ligase TRIM68; RING finger protein 137; RING-type E3 ubiquitin transferase TRIM68; SSA protein SS-56; Tripartite motif-containing protein 68
Genbank Nucleotide ID AF360739; AF439153; AK001231; AK022923; AK291166; AK301120; AK056523; AC090719; BC075058; BC109063; AY005802
Gene Name TRIM68; GC109; RNF137; SS56
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000167333.12 ENST00000300747.9 ENSP00000300747.5
ENSG00000167333.12 ENST00000531101.5 ENSP00000431783.1
ENSG00000167333.12 ENST00000533021.1 ENSP00000436112.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18451177
Classification
Family E-value Score Start End
E3 activity/RING/U-box 6.30e-05 24.6 10 81
E3 activity/RING/RING 1.30e-07 33.7 16 61
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl...asggk......tcPvtrqplteedlvPnltlrrliqa 67
           + ee  CpI ++  r+P+ + +G+++  s++           +      tcP++r+p+++++l Pn  l +++++
   Q: 10   IVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWeipG---EsqnwgyTCPLCRAPVQPRNLRPNWQLANVVEK 81
           67999**************************98554441...2355789*****************999888765 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkw..pglknssskefrCPlCr 46
           C+iC++ +++ p++ +CgH f+++Cl   w  pg +  ++   +CPlCr
   Q: 16   CPICMTFLRE-PMSIDCGHSFCHSCLsGLWeiPGES--QNWGYTCPLCR 61
           ********88.***************8788544444..78888*****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
 Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
Protein Sequence
(Fasta)
MDPTALVEAI VEEVACPICM TFLREPMSID CGHSFCHSCL SGLWEIPGES QNWGYTCPLC 60
RAPVQPRNLR PNWQLANVVE KVRLLRLHPG MGLKGDLCER HGEKLKMFCK EDVLIMCEAC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046031|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTGGCTGCC GTCCCGCGAG CGGGGCCTAG AGCCGGGTGT AGTATTCTGG GAGCTGCGGG 60
CTACTGGGCC TGCGCTGCCG GGCTTTGGGT TCTGGGCCTC TGCCGCTCTC TGGCCCTAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046031|E3,RING;E3,U-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PRINTS

PR01407--BUTYPHLNCDUF
SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0050681--F:androgen receptor binding
GO:0035035--F:histone acetyltransferase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0051865--P:protein autoubiquitination
GO:0060765--P:regulation of androgen receptor signaling pathway
KEGG hsa:55128
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002078 Ailuropoda melanoleuca 89.48 0.00e+00 834.00
IUUC-Ang-009514 Aspergillus niger 33.68 3.00e-08 53.10
IUUC-Bta-012800 Bos taurus 83.76 0.00e+00 847.00
IUUC-Cja-019382 Callithrix jacchus 94.43 0.00e+00 870.00
IUUC-Cfa-020686 Canis familiaris 87.47 1.00e-178 619.00
IUUC-Csa-023952 Chlorocebus sabaeus 97.94 0.00e+00 894.00
IUUC-Cho-024811 Choloepus hoffmanni 78.76 0.00e+00 709.00
IUUC-Dno-029361 Dasypus novemcinctus 83.51 0.00e+00 796.00
IUUC-Dor-030703 Dipodomys ordii 82.89 0.00e+00 774.00
IUUC-Ete-033159 Echinops telfairi 88.43 3.00e-115 408.00
IUUC-Eca-033633 Equus caballus 79.31 0.00e+00 704.00
IUUC-Eeu-034686 Erinaceus europaeus 77.89 0.00e+00 723.00
IUUC-Fca-035750 Felis catus 87.06 0.00e+00 811.00
IUUC-Ggo-045524 Gorilla gorilla 99.59 0.00e+00 911.00
IUUC-Itr-048898 Ictidomys tridecemlineatus 82.89 0.00e+00 766.00
IUUC-Laf-054264 Loxodonta africana 86.13 0.00e+00 850.00
IUUC-Mcc-055388 Macaca mulatta 97.94 0.00e+00 894.00
IUUC-Mmr-060612 Microcebus murinus 82.27 0.00e+00 782.00
IUUC-Mmu-063761 Mus musculus 78.10 0.00e+00 776.00
IUUC-Mpu-066319 Mustela putorius furo 90.10 0.00e+00 840.00
IUUC-Mlu-067368 Myotis lucifugus 86.39 0.00e+00 802.00
IUUC-Nle-069702 Nomascus leucogenys 99.38 0.00e+00 912.00
IUUC-Opr-070810 Ochotona princeps 72.65 0.00e+00 638.00
IUUC-Ont-072259 Oreochromis niloticus 32.44 2.00e-67 249.00
IUUC-Oga-088935 Otolemur garnettii 84.12 0.00e+00 787.00
IUUC-Oar-089940 Ovis aries 88.87 0.00e+00 836.00
IUUC-Ptr-091056 Pan troglodytes 99.18 0.00e+00 908.00
IUUC-Pan-092165 Papio anubis 97.73 0.00e+00 889.00
IUUC-Pab-098415 Pongo abelii 99.39 1.00e-177 615.00
IUUC-Pca-100470 Procavia capensis 79.22 0.00e+00 799.00
IUUC-Pva-102603 Pteropus vampyrus 82.47 0.00e+00 754.00
IUUC-Rno-105709 Rattus norvegicus 74.89 0.00e+00 721.00
IUUC-Sar-113101 Sorex araneus 78.72 1.00e-150 525.00
IUUC-Ssc-115920 Sus scrofa 84.95 0.00e+00 807.00
IUUC-Tbe-127512 Tupaia belangeri 76.73 4.00e-167 580.00
Created Date 25-Jun-2017

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