iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-035468

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02048339

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000001338.3	ENSFCAT00000001338.3	ENSFCAP00000001244.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	7.80e-06	25.9	13	74
E3 activity/RING/RING	2.90e-08	34.1	17	56

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           ee  CpI l++  +Pv +++G+++   +I +  ++gg  cPv+++ +  +++ Pn  l +++
   Q: 13   EEVTCPICLDPVVEPVSIECGHSFCHDCISQVGKDGGGVCPVCQHIFLLRNVRPNWPLANMV 74
           6889***************************9999999****************98777766 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl++  + p++  CgH f++dC+ ++      + +   CP+C+
   Q: 17   CPICLDPVVE-PVSIECGHSFCHDCISQV-----GKDGGGVCPVCQ 56
           ********99.9**************999.....7889999****7 PP

Organism

Felis catus

Protein Sequence
(Fasta)

AMASAAPLAM MWEEVTCPIC LDPVVEPVSI ECGHSFCHDC ISQVGKDGGG VCPVCQHIFL 60
LRNVRPNWPL ANMVDNLKQI GQSAKEGMQR ERCEVHGEKL HLFCEEDGKI LCWVCSQSQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAATGGCCT CAGCAGCGCC CCTGGCGATG ATGTGGGAGG AGGTCACTTG CCCTATCTGC 60
CTGGATCCTG TCGTGGAGCC TGTGAGCATT GAATGTGGCC ACAGCTTCTG CCACGACTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	82.45	0.00e+00	832.00
IUUC-Ang-009772	Aspergillus niger	40.00	3.00e-08	51.60
IUUC-Ate-010384	Aspergillus terreus	38.46	4.00e-07	47.40
IUUC-Bta-013083	Bos taurus	68.97	0.00e+00	654.00
IUUC-Cja-019002	Callithrix jacchus	74.29	0.00e+00	728.00
IUUC-Cfa-020415	Canis familiaris	81.02	0.00e+00	817.00
IUUC-Cpo-021948	Cavia porcellus	65.99	0.00e+00	645.00
IUUC-Csa-023135	Chlorocebus sabaeus	75.31	0.00e+00	675.00
IUUC-Cho-024493	Choloepus hoffmanni	64.79	7.00e-92	330.00
IUUC-Dno-030061	Dasypus novemcinctus	67.87	0.00e+00	676.00
IUUC-Ete-033168	Echinops telfairi	64.88	1.00e-164	572.00
IUUC-Eca-033578	Equus caballus	74.54	0.00e+00	737.00
IUUC-Eeu-034749	Erinaceus europaeus	53.32	4.00e-125	441.00
IUUC-Ggo-045190	Gorilla gorilla	74.69	0.00e+00	704.00
IUUC-Hsa-046583	Homo sapiens	74.69	0.00e+00	701.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	71.14	0.00e+00	665.00
IUUC-Laf-053455	Loxodonta africana	71.13	0.00e+00	665.00
IUUC-Mcc-054609	Macaca mulatta	75.10	0.00e+00	673.00
IUUC-Mmr-061369	Microcebus murinus	68.64	8.00e-175	606.00
IUUC-Mmu-063166	Mus musculus	64.26	4.00e-177	613.00
IUUC-Mpu-066889	Mustela putorius furo	80.00	0.00e+00	810.00
IUUC-Mlu-067647	Myotis lucifugus	75.36	0.00e+00	681.00
IUUC-Nle-069567	Nomascus leucogenys	73.47	0.00e+00	690.00
IUUC-Opr-071178	Ochotona princeps	68.98	1.00e-87	317.00
IUUC-Oar-090413	Ovis aries	72.86	0.00e+00	677.00
IUUC-Ptr-091187	Pan troglodytes	74.69	0.00e+00	701.00
IUUC-Pan-092231	Papio anubis	75.10	0.00e+00	672.00
IUUC-Pfo-096972	Poecilia formosa	32.61	3.00e-64	239.00
IUUC-Pab-098079	Pongo abelii	69.05	3.00e-138	484.00
IUUC-Pca-100639	Procavia capensis	67.45	9.00e-140	489.00
IUUC-Pva-102476	Pteropus vampyrus	74.90	0.00e+00	717.00
IUUC-Rno-105054	Rattus norvegicus	64.36	3.00e-160	558.00
IUUC-Sar-113204	Sorex araneus	69.84	0.00e+00	639.00
IUUC-Ssc-116291	Sus scrofa	73.27	0.00e+00	696.00
IUUC-Tsy-118803	Tarsius syrichta	67.80	1.00e-123	436.00
IUUC-Ttr-128914	Tursiops truncatus	71.43	2.00e-180	624.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence