iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065802

Ensembl Protein ID

ENSMPUP00000010903.1

UniProt Accession

M3YHU6; M3YHU6_MUSPF

Genbank Protein ID

ENSMPUP00000010903

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01042255

Gene Name

TRAF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000010992.1	ENSMPUT00000011085.1	ENSMPUP00000010903.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	87.50	0.00e+00	925.00	IUUC-Hsa-046952

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MVSSGRSGAA WPRVTHAGAA TGPRSAPFLR PPRFMGLRSR WAERARWCAA LMAAAGATPP 60
GSLDLLQPGF SKTLLGTKPE DKYLCSACRN VLRRPFQAQC GHRYCSSCLT SILSSGPQNC 120

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Nucleotide Sequence
(Fasta)

CTGCGGGTGG TTCCCGGGAC AGCCTTGGTG TCCCAGATGC CGGGAGGAGC CCCGTTAGTT 60
ACAGGATTTG GACGAAACCT CACCGAACCT GTAAGTCGGC CTGGGGAGGT GCTTGTGGCA 120

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Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027133--TRAF2
IPR032070--TRAF_BIRC3-bd
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF16673--TRAF_BIRC3_bd
PF00097--zf-C3HC4
PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:1990597--C:AIP1-IRE1 complex
GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:0045121--C:membrane raft
GO:0097057--C:TRAF2-GSTP1 complex
GO:0000151--C:ubiquitin ligase complex
GO:0012506--C:vesicle membrane
GO:0046625--F:sphingolipid binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0043623--P:cellular protein complex assembly
GO:0071732--P:cellular response to nitric oxide
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:1903721--P:positive regulation of I-kappaB phosphorylation
GO:0032743--P:positive regulation of interleukin-2 production
GO:0043507--P:positive regulation of JUN kinase activity
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0002726--P:positive regulation of T cell cytokine production
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0097300--P:programmed necrotic cell death
GO:0051865--P:protein autoubiquitination
GO:0030163--P:protein catabolic process
GO:0070207--P:protein homotrimerization
GO:0070534--P:protein K63-linked ubiquitination
GO:0051023--P:regulation of immunoglobulin secretion
GO:0033209--P:tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002344	Ailuropoda melanoleuca	93.62	0.00e+00	979.00
IUUC-Apl-004202	Anas platyrhynchos	74.10	0.00e+00	822.00
IUUC-Aca-005029	Anolis carolinensis	56.50	3.00e-144	504.00
IUUC-Ame-011841	Astyanax mexicanus	57.07	0.00e+00	664.00
IUUC-Bta-013180	Bos taurus	87.89	0.00e+00	900.00
IUUC-Cja-019813	Callithrix jacchus	87.30	0.00e+00	926.00
IUUC-Cfa-021205	Canis familiaris	92.38	0.00e+00	954.00
IUUC-Cpo-021346	Cavia porcellus	84.77	0.00e+00	885.00
IUUC-Csa-023809	Chlorocebus sabaeus	86.96	0.00e+00	823.00
IUUC-Dre-027669	Danio rerio	56.94	5.00e-177	613.00
IUUC-Dno-029458	Dasypus novemcinctus	80.66	0.00e+00	865.00
IUUC-Dor-030338	Dipodomys ordii	81.64	0.00e+00	789.00
IUUC-Eca-034401	Equus caballus	90.04	0.00e+00	954.00
IUUC-Eeu-034668	Erinaceus europaeus	92.81	1.00e-84	306.00
IUUC-Fca-036057	Felis catus	93.23	0.00e+00	996.00
IUUC-Fal-037560	Ficedula albicollis	68.74	0.00e+00	707.00
IUUC-Gmo-038964	Gadus morhua	61.87	0.00e+00	665.00
IUUC-Gga-040425	Gallus gallus	74.38	0.00e+00	820.00
IUUC-Gac-041908	Gasterosteus aculeatus	63.50	0.00e+00	678.00
IUUC-Ggo-044606	Gorilla gorilla	80.66	0.00e+00	838.00
IUUC-Hsa-046952	Homo sapiens	87.50	0.00e+00	924.00
IUUC-Itr-049016	Ictidomys tridecemlineatus	72.34	0.00e+00	749.00
IUUC-Lch-049571	Latimeria chalumnae	59.58	0.00e+00	704.00
IUUC-Loc-051973	Lepisosteus oculatus	62.30	0.00e+00	633.00
IUUC-Laf-053815	Loxodonta africana	83.63	0.00e+00	861.00
IUUC-Mcc-054888	Macaca mulatta	87.70	0.00e+00	922.00
IUUC-Meu-056547	Macropus eugenii	69.67	0.00e+00	643.00
IUUC-Mga-059819	Meleagris gallopavo	72.37	0.00e+00	773.00
IUUC-Mdo-062570	Monodelphis domestica	79.10	0.00e+00	840.00
IUUC-Mmu-063133	Mus musculus	81.64	0.00e+00	838.00
IUUC-Nle-070155	Nomascus leucogenys	88.09	0.00e+00	933.00
IUUC-Opr-070856	Ochotona princeps	76.33	2.00e-107	382.00
IUUC-Ont-071930	Oreochromis niloticus	64.65	0.00e+00	713.00
IUUC-Ola-087397	Oryzias latipes	62.71	0.00e+00	694.00
IUUC-Oga-088109	Otolemur garnettii	86.91	0.00e+00	920.00
IUUC-Oar-090310	Ovis aries	78.18	0.00e+00	794.00
IUUC-Ptr-090643	Pan troglodytes	88.09	0.00e+00	930.00
IUUC-Pan-091933	Papio anubis	87.89	0.00e+00	923.00
IUUC-Psi-093681	Pelodiscus sinensis	73.37	0.00e+00	786.00
IUUC-Pfo-096148	Poecilia formosa	62.15	0.00e+00	699.00
IUUC-Pab-098631	Pongo abelii	88.09	0.00e+00	932.00
IUUC-Pca-100582	Procavia capensis	61.59	4.00e-84	305.00
IUUC-Pva-102396	Pteropus vampyrus	72.85	0.00e+00	728.00
IUUC-Rno-106120	Rattus norvegicus	80.27	0.00e+00	824.00
IUUC-Sha-106493	Sarcophilus harrisii	79.69	0.00e+00	864.00
IUUC-Sar-113570	Sorex araneus	94.48	1.00e-100	359.00
IUUC-Ssc-115843	Sus scrofa	87.16	0.00e+00	923.00
IUUC-Tgu-117144	Taeniopygia guttata	66.28	0.00e+00	677.00
IUUC-Tru-117853	Takifugu rubripes	63.29	0.00e+00	698.00
IUUC-Tni-120256	Tetraodon nigroviridis	65.43	0.00e+00	717.00
IUUC-Tbe-127943	Tupaia belangeri	61.78	1.00e-97	349.00
IUUC-Ttr-129246	Tursiops truncatus	87.89	0.00e+00	888.00
IUUC-Xtr-132279	Xenopus tropicalis	58.01	1.00e-170	592.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence